INT65597

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2011
Negated 3
Speculated 0
Reported most in Abstract
Documents 69
Total Number 69
Disease Relevance 39.19
Pain Relevance 29.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleus (Casp3) intracellular (Casp3) cytoplasm (Casp3)
Anatomy Link Frequency
spinal cord 2
prefrontal 2
brain 1
eosinophils 1
neuronal 1
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 185 100.00 Very High Very High Very High
Eae 37 100.00 Very High Very High Very High
cocaine 15 99.98 Very High Very High Very High
Dopamine 158 99.82 Very High Very High Very High
Spinal cord 54 99.72 Very High Very High Very High
Glutamate 19 99.64 Very High Very High Very High
cva 32 99.40 Very High Very High Very High
COX-2 inhibitor 38 99.20 Very High Very High Very High
Clonidine 9 99.20 Very High Very High Very High
tetrodotoxin 20 99.14 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 770 100.00 Very High Very High Very High
Injury 112 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 29 100.00 Very High Very High Very High
Death 348 99.92 Very High Very High Very High
Toxicity 75 99.82 Very High Very High Very High
Influenza Virus Infection 38 99.80 Very High Very High Very High
Frailty 14 99.72 Very High Very High Very High
Shock 75 99.46 Very High Very High Very High
Cv General 3 Under Development 30 99.40 Very High Very High Very High
Endometriosis (extended) 26 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Caspase-3 activity at the injury site was significantly decreased in tissue homogenates from prodynorphin(-/-) mice after 4 h.
Negative_regulation (decreased) of Caspase-3 associated with injury
1) Confidence 0.59 Published 2007 Journal Neuroscience Section Abstract Doc Link 17698296 Disease Relevance 0.90 Pain Relevance 0.25
Caspase-3 activity is reduced after spinal cord injury in mice lacking dynorphin: differential effects on glia and neurons.
Negative_regulation (reduced) of Caspase-3 in neurons associated with dynorphin and spinal cord
2) Confidence 0.59 Published 2007 Journal Neuroscience Section Title Doc Link 17698296 Disease Relevance 0.80 Pain Relevance 0.28
Moreover, dynorphin A-induced neurotoxicity and caspase-3 activation were significantly attenuated by the cell permeable caspase inhibitor, caspase-3 inhibitor-II (z-DEVD-FMK), further suggesting an apoptotic cascade involving caspase-3.
Negative_regulation (inhibitor) of caspase-3 associated with drug induced neurotoxicity, dynorphin and apoptosis
3) Confidence 0.58 Published 2003 Journal Neuroscience Section Abstract Doc Link 14643768 Disease Relevance 0.70 Pain Relevance 0.84
Clonidine and prazosin reversed, while yohimbine decreased morphine-induced CPP.
Negative_regulation (decreased) of CPP associated with morphine and clonidine
4) Confidence 0.51 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12213541 Disease Relevance 0 Pain Relevance 1.42
However, ovariectomized mice showed decreased CPP compared to gonadally intact mice with a right shift in their morphine dose-response curve.
Negative_regulation (decreased) of CPP associated with morphine
5) Confidence 0.51 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19463255 Disease Relevance 0 Pain Relevance 0.49
However, in mice treated with morphine for 4 days, all doses of scopolamine did not inhibit morphine-induced CPP.
Negative_regulation (inhibit) of CPP associated with morphine
6) Confidence 0.51 Published 2007 Journal Addict Biol Section Abstract Doc Link 17678506 Disease Relevance 0 Pain Relevance 0.90
Paeonol inhibited morphine-induced hyperlocomotion, sensitization and CPP.
Negative_regulation (inhibited) of CPP associated with morphine
7) Confidence 0.46 Published 2006 Journal Arch. Pharm. Res. Section Abstract Doc Link 17121187 Disease Relevance 0 Pain Relevance 0.79
Treatment of MCJ 100 mg/kg inhibited morphine-induced CPP.
Negative_regulation (inhibited) of CPP associated with morphine
8) Confidence 0.44 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 12934646 Disease Relevance 0.16 Pain Relevance 1.20
Morphine-induced CPP was reversed by the administration of SCH 23390 and risperidone (all doses), haloperidol (highest dose) and raclopride and clozapine (intermediate and lowest doses).
Negative_regulation (reversed) of CPP associated with morphine
9) Confidence 0.43 Published 2001 Journal Behav. Brain Res. Section Abstract Doc Link 11275296 Disease Relevance 0 Pain Relevance 0.78
MK-801 and memantine, at all doses used, produced neither place preference nor place aversion, but the higher doses of memantine (20 and 40 mg/kg) were able to completely block morphine-induced CPP.
Negative_regulation (block) of CPP associated with morphine
10) Confidence 0.42 Published 2004 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 15380865 Disease Relevance 0 Pain Relevance 0.78
In contrast, 5HT1A activation (which occurs preferentially after menopause) decreases apoptotic signaling via caspase-3 suppression [38].
Negative_regulation (suppression) of caspase-3 associated with endometriosis (extended) and apoptosis
11) Confidence 0.42 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.80 Pain Relevance 0.13
It blocks common downstream elements of both the mitochondrial pathway and the death receptor pathway, by directly inhibiting terminal effector caspase-3, caspase-7, and caspase-9 activity[1,2].
Negative_regulation (inhibiting) of caspase-3 associated with death
12) Confidence 0.42 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1266027 Disease Relevance 0.78 Pain Relevance 0
of caspase 3 and inhibition of cyclin D1 by the combination was not reversed by
Neg (not) Negative_regulation (reversed) of caspase 3
13) Confidence 0.41 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.17 Pain Relevance 0.21
CPP effects were evaluated assessing the increased time spent by the mice to morphine and the inhibition of CPP by the decreased time spent by the mice in the nonpreferred compartment.
Negative_regulation (inhibition) of CPP associated with morphine
14) Confidence 0.41 Published 1999 Journal J Ethnopharmacol Section Abstract Doc Link 10432204 Disease Relevance 0 Pain Relevance 0.81
Meyer (Araliaceae), prior to and during the morphine treatment in mice inhibited morphine-induced hyperactivity and CPP.
Negative_regulation (inhibited) of CPP associated with attention deficit hyperactivity disorder and morphine
15) Confidence 0.40 Published 1998 Journal J Ethnopharmacol Section Abstract Doc Link 9533430 Disease Relevance 0.32 Pain Relevance 1.12
In Experiment 1, the persistence of morphine-induced CPP was evaluated weekly.
Negative_regulation (persistence) of CPP associated with morphine
16) Confidence 0.38 Published 2005 Journal Brain Res. Section Abstract Doc Link 15967418 Disease Relevance 0 Pain Relevance 0.49
In the second set of experiments, when the drugs were used before testing on Day 6, in order to test their effects on the expression of morphine-induced CPP, imipramine (0.5-5 mg/kg) reversed morphine-induced CPP and this reversal was blocked by naloxone (2 mg/kg).
Negative_regulation (reversed) of CPP associated with narcan and morphine
17) Confidence 0.38 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12213541 Disease Relevance 0 Pain Relevance 1.42
U-99194A maleate did not reverse morphine-induced CPP.
Neg (not) Negative_regulation (reverse) of CPP associated with morphine
18) Confidence 0.38 Published 2001 Journal Behav. Brain Res. Section Abstract Doc Link 11275296 Disease Relevance 0 Pain Relevance 0.78
Injection of extract (25, 50 and 100 mg/kg, i.p.) 30 min before the morphine administration decreased the acquisition of morphine CPP.
Negative_regulation (decreased) of CPP associated with morphine
19) Confidence 0.38 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16182480 Disease Relevance 0 Pain Relevance 0.66
The capsaicin-induced apoptosis was blocked by the pretreatment with Z-VAD-fmk, a broad-range caspase inhibitor, or Ac-DEVD-CHO, a caspase-3 inhibitor.
Negative_regulation (inhibitor) of caspase-3 associated with qutenza and apoptosis
20) Confidence 0.36 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15595419 Disease Relevance 1.52 Pain Relevance 0.75

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