INT65598

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 45
Total Number 47
Disease Relevance 18.36
Pain Relevance 28.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleus (Casp3) intracellular (Casp3) cytoplasm (Casp3)
Anatomy Link Frequency
cleavage 6
spinal cord 2
apoptotic cell 2
dopamine neuron 2
precursor cells 2
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 198 100.00 Very High Very High Very High
cocaine 20 100.00 Very High Very High Very High
fluoxetine 19 100.00 Very High Very High Very High
Spinal cord 9 100.00 Very High Very High Very High
antagonist 32 99.98 Very High Very High Very High
Clonidine 12 99.98 Very High Very High Very High
agonist 39 99.96 Very High Very High Very High
Lamotrigine 10 99.84 Very High Very High Very High
nMDA receptor antagonist 21 99.68 Very High Very High Very High
Paracetamol 91 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 364 100.00 Very High Very High Very High
Targeted Disruption 145 100.00 Very High Very High Very High
Frailty 9 100.00 Very High Very High Very High
Death 134 99.86 Very High Very High Very High
Neuroblastoma 3 99.76 Very High Very High Very High
Alzheimer's Dementia 43 99.48 Very High Very High Very High
Lung Cancer 14 99.36 Very High Very High Very High
Injury 130 99.28 Very High Very High Very High
Stress 81 98.88 Very High Very High Very High
INFLAMMATION 15 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
N(2)O did not induce CPP but impaired the acquisition of morphine-induced CPP and blocked the expression of cocaine- and morphine-induced CPP.
Negative_regulation (impaired) of Positive_regulation (induced) of CPP associated with cocaine and morphine
1) Confidence 0.59 Published 2007 Journal Neuroscience Section Abstract Doc Link 17905521 Disease Relevance 0.38 Pain Relevance 0.83
The oral administration of velvet antler water extract (VAWE) from Cerrus elaphus, prior to the morphine treatment in mice inhibited the development of morphine-induced CPP and postsynaptic DA receptor supersensitivity.
Negative_regulation (inhibited) of Positive_regulation (induced) of CPP associated with dopamine and morphine
2) Confidence 0.56 Published 1999 Journal J Ethnopharmacol Section Abstract Doc Link 10432204 Disease Relevance 0 Pain Relevance 1.05
Clonidine and prazosin reversed, while yohimbine decreased morphine-induced CPP.
Negative_regulation (decreased) of Positive_regulation (induced) of CPP associated with morphine and clonidine
3) Confidence 0.51 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12213541 Disease Relevance 0 Pain Relevance 1.42
However, in mice treated with morphine for 4 days, all doses of scopolamine did not inhibit morphine-induced CPP.
Negative_regulation (inhibit) of Neg (not) Positive_regulation (induced) of CPP associated with morphine
4) Confidence 0.51 Published 2007 Journal Addict Biol Section Abstract Doc Link 17678506 Disease Relevance 0 Pain Relevance 0.90
Treatment of MCJ 100 mg/kg inhibited morphine-induced CPP.
Negative_regulation (inhibited) of Positive_regulation (induced) of CPP associated with morphine
5) Confidence 0.44 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 12934646 Disease Relevance 0.16 Pain Relevance 1.20
Morphine-induced CPP was reversed by the administration of SCH 23390 and risperidone (all doses), haloperidol (highest dose) and raclopride and clozapine (intermediate and lowest doses).
Negative_regulation (reversed) of Positive_regulation (induced) of CPP associated with morphine
6) Confidence 0.43 Published 2001 Journal Behav. Brain Res. Section Abstract Doc Link 11275296 Disease Relevance 0 Pain Relevance 0.78
MK-801 and memantine, at all doses used, produced neither place preference nor place aversion, but the higher doses of memantine (20 and 40 mg/kg) were able to completely block morphine-induced CPP.
Negative_regulation (block) of Positive_regulation (induced) of CPP associated with morphine
7) Confidence 0.42 Published 2004 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 15380865 Disease Relevance 0 Pain Relevance 0.78
N(2)O did not induce CPP but impaired the acquisition of morphine-induced CPP and blocked the expression of cocaine- and morphine-induced CPP.
Negative_regulation (blocked) of Positive_regulation (induced) of CPP associated with cocaine and morphine
8) Confidence 0.38 Published 2007 Journal Neuroscience Section Abstract Doc Link 17905521 Disease Relevance 0.38 Pain Relevance 0.84
In Experiment 1, the persistence of morphine-induced CPP was evaluated weekly.
Negative_regulation (persistence) of Positive_regulation (induced) of CPP associated with morphine
9) Confidence 0.38 Published 2005 Journal Brain Res. Section Abstract Doc Link 15967418 Disease Relevance 0 Pain Relevance 0.49
Yohimbine increased, while clonidine and prazosin reversed, morphine-induced CPP.
Negative_regulation (reversed) of Positive_regulation (induced) of CPP associated with morphine and clonidine
10) Confidence 0.38 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12213541 Disease Relevance 0 Pain Relevance 1.24
In the second set of experiments, when the drugs were used before testing on Day 6, in order to test their effects on the expression of morphine-induced CPP, imipramine (0.5-5 mg/kg) reversed morphine-induced CPP and this reversal was blocked by naloxone (2 mg/kg).
Negative_regulation (reversed) of Positive_regulation (induced) of CPP associated with narcan and morphine
11) Confidence 0.38 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12213541 Disease Relevance 0 Pain Relevance 1.42
U-99194A maleate did not reverse morphine-induced CPP.
Neg (not) Negative_regulation (reverse) of Positive_regulation (induced) of CPP associated with morphine
12) Confidence 0.38 Published 2001 Journal Behav. Brain Res. Section Abstract Doc Link 11275296 Disease Relevance 0 Pain Relevance 0.78
Acquisition and expression of morphine-induced CPP were reduced by lamotrigine at doses of 1, 5 and 25 mg kg(-1) and 5 and 25 mg kg(-1), respectively.
Negative_regulation (reduced) of Positive_regulation (induced) of CPP associated with lamotrigine and morphine
13) Confidence 0.38 Published 2009 Journal Pak. J. Biol. Sci. Section Abstract Doc Link 19579915 Disease Relevance 0 Pain Relevance 1.15
IP), prior to and during morphine treatment in mice inhibited morphine-induced CPP.
Negative_regulation (inhibited) of Positive_regulation (induced) of CPP associated with morphine
14) Confidence 0.35 Published 1996 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8870032 Disease Relevance 0 Pain Relevance 0.93
Caspase-1 and caspase-3 activation were also detected by western blot following spinal cord injury, which was significantly inhibited by the broad caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone.
Negative_regulation (inhibited) of Positive_regulation (activation) of caspase-3 in spinal cord associated with spinal cord
15) Confidence 0.34 Published 2000 Journal Neuroscience Section Abstract Doc Link 10938439 Disease Relevance 1.00 Pain Relevance 0.43
Blocking activation of caspase-3 and induction of oxidative stress by caspase inhibitor and by glutathione, respectively, markedly reduced apoptotic cell death in vitro.
Negative_regulation (Blocking) of Positive_regulation (activation) of caspase-3 in apoptotic cell associated with stress, apoptosis and death
16) Confidence 0.32 Published 2008 Journal Cancer Sci. Section Abstract Doc Link 19016762 Disease Relevance 1.38 Pain Relevance 0
In experiment 2, CGS 10746B did not produce any effect on place conditioning but blocked morphine-induced CPP with doses from 1 mg/kg upwards.
Negative_regulation (blocked) of Positive_regulation (induced) of CPP associated with morphine
17) Confidence 0.31 Published 2001 Journal Behav. Brain Res. Section Abstract Doc Link 11704248 Disease Relevance 0.32 Pain Relevance 1.00
Treatment with acetaminophen 2.5 h before Jo inhibited the increase in hepatic caspase-3 activity by preventing the processing of the proenzyme.
Negative_regulation (inhibited) of Positive_regulation (increase) of caspase-3 associated with paracetamol
18) Confidence 0.31 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12051997 Disease Relevance 0.84 Pain Relevance 0.72
Several studies have shown that the systemic administration of a variety of N-methyl-D-aspartate (NMDA) receptor antagonists can block the development or expression of conditioned place preference (CPP) induced by rewarding drugs such as morphine.
Negative_regulation (block) of Positive_regulation (induced) of CPP associated with antagonist and morphine
19) Confidence 0.31 Published 2004 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 15380865 Disease Relevance 0 Pain Relevance 0.39
The present data show that the NMDA receptor antagonists MK-801 and memantine have no reinforcing properties but memantine is capable of preventing the acquisition of morphine-induced CPP.
Negative_regulation (preventing) of Positive_regulation (morphine-induced) of CPP associated with nmda receptor antagonist and morphine
20) Confidence 0.31 Published 2004 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 15380865 Disease Relevance 0 Pain Relevance 0.80

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