INT65599

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Context Info
Confidence 0.38
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.97
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rpsa) structural constituent of ribosome (Rpsa) ribosome (Rpsa)
plasma membrane (Rpsa) nucleus (Rpsa) intracellular (Rpsa)
Anatomy Link Frequency
heart 1
Rpsa (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 62 100.00 Very High Very High Very High
Morphine 19 99.98 Very High Very High Very High
Nucleus accumbens 32 99.68 Very High Very High Very High
nMDA receptor 2 98.24 Very High Very High Very High
Glutamate receptor 2 97.36 Very High Very High Very High
cytokine 22 97.28 Very High Very High Very High
antagonist 13 93.28 High High
gABA 1 92.84 High High
Inflammation 14 85.24 High High
c fibre 1 84.80 Quite High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 5 97.56 Very High Very High Very High
Disease 61 85.88 High High
INFLAMMATION 16 85.24 High High
Paralysis 1 82.84 Quite High
Meningoencephalitis 11 72.60 Quite High
Immunization 15 64.60 Quite High
Recurrence 2 56.56 Quite High
Targeted Disruption 14 49.12 Quite Low
Encephalitis 1 38.16 Quite Low
Multiple Sclerosis 2 36.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All of the changes evoked by electrical and chemical stimulation of the MLR were accompanied by increases in arterial pressure, heart rate, and ventral root motoneuron discharge.
Positive_regulation (stimulation) of MLR in heart
1) Confidence 0.38 Published 1996 Journal Respir Physiol Section Abstract Doc Link 9017845 Disease Relevance 0.08 Pain Relevance 0.18
The development of morphine-induced CPP and DA receptor supersensitivity may be closely related to NMDA receptor-mediated dopaminergic activity, because morphine-induced changes in sensitivity to apomorphine, as well as apomorphine-induced climbing behavior in morphine treated mice, were both blocked by MK-801.
Positive_regulation (induced) of DA receptor associated with dopamine, nmda receptor and morphine
2) Confidence 0.14 Published 1996 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8870032 Disease Relevance 0 Pain Relevance 1.21
IL-12 is composed of p40
Positive_regulation (composed) of p40
3) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.46 Pain Relevance 0.20
These results suggest that the development of morphine-induced CPP may be associated with the enhanced DA receptor sensitivity and that GTS inhibition of the morphine-induced hyperactivity and CPP may be closely related with the inhibition of dopaminergic activation induced by morphine.
Positive_regulation (enhanced) of DA receptor associated with dopamine, attention deficit hyperactivity disorder and morphine
4) Confidence 0.05 Published 1998 Journal J Ethnopharmacol Section Abstract Doc Link 9533430 Disease Relevance 0.37 Pain Relevance 1.10
Thus, phosphorylation of ERK provides an index of post-synaptic DA receptor activation in the NAcc.
Positive_regulation (activation) of DA receptor associated with nucleus accumbens and dopamine
5) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775951 Disease Relevance 0.06 Pain Relevance 0.44

General Comments

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