INT656

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Context Info
Confidence 0.18
First Reported 1977
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.89
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 4
plasma 3
follicle 1
ATP6AP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 4 99.46 Very High Very High Very High
Clonidine 8 99.36 Very High Very High Very High
cytokine 2 63.04 Quite High
Bioavailability 2 36.84 Quite Low
iatrogenic 1 32.40 Quite Low
tolerance 1 25.00 Low Low
Calcium channel 1 23.36 Low Low
agonist 1 5.52 Low Low
fibrosis 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 45 98.96 Very High Very High Very High
Ovarian Hyperstimulation Syndrome 29 98.44 Very High Very High Very High
Edema 3 93.12 High High
Pleural Effusion 14 91.40 High High
Pressure And Volume Under Development 17 90.56 High High
Volume Depletion And Dehydration 1 87.28 High High
Hydrothorax 2 83.36 Quite High
Necrosis 3 64.60 Quite High
Diabetes Mellitus 23 64.24 Quite High
Cancer 3 64.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, sodium depletion stimulates total renin release, while propranolol and clonidine produce divergent responses of active renin and prorenin, the changes in prorenin depending on the changes induced in blood-pressure.
Positive_regulation (active) of prorenin in blood associated with clonidine
1) Confidence 0.18 Published 1977 Journal Lancet Section Abstract Doc Link 71600 Disease Relevance 0.14 Pain Relevance 0.19
The relative proportions of active renin and this cryoactivatable "prorenin" in plasmas of untreated hypertensive patients varied widely.
Positive_regulation (cryoactivatable) of prorenin in plasmas associated with hypertension
2) Confidence 0.18 Published 1977 Journal Lancet Section Abstract Doc Link 71600 Disease Relevance 0.17 Pain Relevance 0
In contrast, propranolol administration in 22 patients lowered active renin in all, but it increased prorenin by 98% in 15 in whom systolic pressure fell.
Positive_regulation (increased) of prorenin
3) Confidence 0.17 Published 1977 Journal Lancet Section Abstract Doc Link 71600 Disease Relevance 0.16 Pain Relevance 0.11
In the other 7 blood-pressure did not change, and beta-blockade produced a fall in total renin (active renin plus prorenin) while prorenin was unchanged.
Neg (unchanged) Positive_regulation (unchanged) of prorenin in blood
4) Confidence 0.17 Published 1977 Journal Lancet Section Abstract Doc Link 71600 Disease Relevance 0.16 Pain Relevance 0.14
Plasma and serum of healthy subjects apparently contain a precursor form of renin, or 'prorenin,' which can be activated by the ice-cold temperature at which samples are customarily handled for prolonged periods in laboratories and blood banks.
Positive_regulation (activated) of prorenin in blood
5) Confidence 0.04 Published 1978 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 709420 Disease Relevance 0 Pain Relevance 0
Since the renin--angiotensin systems of dogs, rabbits, and rats have been extensively studied in experimental models of human hypertension, these observed departures from human levels of cryoactivation and tryptic activation of prorenin deserve further investigation.
Positive_regulation (activation) of prorenin associated with hypertension
6) Confidence 0.04 Published 1978 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 709420 Disease Relevance 0.10 Pain Relevance 0
Cryoactivation and tryptic activation of blood 'prorenin' in normal man and animals.
Positive_regulation (activation) of prorenin in blood associated with anesthesia
7) Confidence 0.04 Published 1978 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 709420 Disease Relevance 0 Pain Relevance 0.10
In dog plasma, prorenin activation requires much higher trypsin concentrations - 3-5 mg/ml, vs 0.5-1.5 mg in humans - implying a higher content of endogenous protease inhibitors, and/or the lack of some endogenous mediator of the action of trypsin.
Positive_regulation (activation) of prorenin in plasma
8) Confidence 0.03 Published 1982 Journal Clin Exp Hypertens A Section Abstract Doc Link 6756692 Disease Relevance 0 Pain Relevance 0
Concerns have been expressed about the high aliskiren-induced reactive increase in plasma renin and prorenin, because even though aliskiren may lack enzymatic activity, it can still bind to the RPR, a signaling pathway of as yet unknown significance.13 An important question is whether aliskiren inhibits the enzymatic effects of renin/prorenin when they are bound to the RPR.
Positive_regulation (increase) of prorenin in plasma
9) Confidence 0.02 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952455 Disease Relevance 0.25 Pain Relevance 0
Navot et al. [11] detected high levels of prorenin and angiotensin 2 in patients' follicle fluid and high renin concentrations in their plasma.
Positive_regulation (levels) of prorenin in follicle
10) Confidence 0.00 Published 2008 Journal Cases J Section Body Doc Link PMC2596110 Disease Relevance 1.91 Pain Relevance 0.03

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