INT65600

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 17
Speculated 7
Reported most in Abstract
Documents 376
Total Number 387
Disease Relevance 198.44
Pain Relevance 128.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleus (Casp3) intracellular (Casp3) cytoplasm (Casp3)
Anatomy Link Frequency
cleavage 13
neurons 11
brain 9
neuronal 6
retina 5
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 812 100.00 Very High Very High Very High
cocaine 677 100.00 Very High Very High Very High
Clonidine 43 100.00 Very High Very High Very High
agonist 710 99.98 Very High Very High Very High
Serotonin 477 99.98 Very High Very High Very High
fluoxetine 26 99.98 Very High Very High Very High
qutenza 68 99.92 Very High Very High Very High
Dynorphin 56 99.92 Very High Very High Very High
Cannabinoid 1185 99.82 Very High Very High Very High
Paracetamol 183 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 5259 100.00 Very High Very High Very High
Death 2012 100.00 Very High Very High Very High
Cancer 5760 99.98 Very High Very High Very High
Injury 527 99.98 Very High Very High Very High
Drug Induced Neurotoxicity 66 99.90 Very High Very High Very High
Reprotox - General 1 48 99.84 Very High Very High Very High
Neuroblastoma 177 99.76 Very High Very High Very High
Disease 1477 99.72 Very High Very High Very High
Shock 100 99.72 Very High Very High Very High
Pressure And Volume Under Development 194 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, intestinal caspase-3 activity increased by 83% in animals given indomethacin but this rise was truncated by 70% by co-presence of hydrolysate (p<0.01).
Positive_regulation (increased) of caspase-3
1) Confidence 0.70 Published 2009 Journal Regul. Pept. Section Body Doc Link 19323982 Disease Relevance 0.06 Pain Relevance 0
N(2)O did not induce CPP but impaired the acquisition of morphine-induced CPP and blocked the expression of cocaine- and morphine-induced CPP.
Positive_regulation (induced) of CPP associated with cocaine and morphine
2) Confidence 0.70 Published 2007 Journal Neuroscience Section Abstract Doc Link 17905521 Disease Relevance 0.37 Pain Relevance 0.82
It appeared that pre-administration with bicuculline (GABA(A) receptor antagonist) (1.5 mg/kg, i.p., 20 min before essential oil) diminished the effect of the essential oil of the P. anisum on morphine which induced CPP, but this result was not found for the GABA(B) receptor antagonist, CGP35348 (200 and 400 mg/kg, i.p., 10 min before essential oil).
Positive_regulation (induced) of CPP associated with gaba, antagonist and morphine
3) Confidence 0.69 Published 2002 Journal J Ethnopharmacol Section Abstract Doc Link 11891086 Disease Relevance 0.06 Pain Relevance 0.93
Importantly, caspase-3 activation was significantly lower in prodynorphin(-/-) oligodendrocytes and astrocytes, as compared with wild-type mice.
Positive_regulation (activation) of caspase-3 in oligodendrocytes
4) Confidence 0.69 Published 2007 Journal Neuroscience Section Abstract Doc Link 17698296 Disease Relevance 0.95 Pain Relevance 0.35
By promoting caspase-3 activation, dynorphin peptides likely increase the probability of glial apoptosis after SCI.
Positive_regulation (activation) of caspase-3 associated with dynorphin, frailty and apoptosis
5) Confidence 0.69 Published 2007 Journal Neuroscience Section Abstract Doc Link 17698296 Disease Relevance 0.81 Pain Relevance 0.31
Our results indicate that dynorphin peptides affect the extent of post-injury caspase-3 activation, and that glia are especially sensitive to these effects.
Positive_regulation (activation) of caspase-3 associated with dynorphin and injury
6) Confidence 0.69 Published 2007 Journal Neuroscience Section Abstract Doc Link 17698296 Disease Relevance 0.92 Pain Relevance 0.34
CONCLUSIONS: The results demonstrate that C57 and DBA mice differ in their sensitivity to cocaine- and morphine-induced CPP and suggest that the two strains differ in sensitivity to the positive incentive properties of drugs of abuse.


Positive_regulation (induced) of CPP
7) Confidence 0.69 Published 2005 Journal Psychopharmacology (Berl.) Section Body Doc Link 15864555 Disease Relevance 0 Pain Relevance 0
The results show that dynorphin A (1-17) (>or=10 nM) caused concentration-dependent increases in caspase-3 activity that were accompanied by mitochondrial release of cytochrome c and the subsequent death of cultured mouse striatal neurons.
Positive_regulation (increases) of caspase-3 in neurons associated with dynorphin and death
8) Confidence 0.69 Published 2003 Journal Neuroscience Section Abstract Doc Link 14643768 Disease Relevance 0.62 Pain Relevance 0.87
Last, dynorphin-induced caspase-3 activation was mimicked by the ampakine CX546 [1-(1,4-benzodioxan-6-ylcarbonyl)piperidine], which suggests that the activation of AMPA receptor subunits may be sufficient to mediate toxicity in striatal neurons.
Positive_regulation (activation) of caspase-3 in neurons associated with toxicity and dynorphin
9) Confidence 0.69 Published 2003 Journal Neuroscience Section Abstract Doc Link 14643768 Disease Relevance 0.63 Pain Relevance 0.62
Dynorphin A (1-17) induces apoptosis in striatal neurons in vitro through alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor-mediated cytochrome c release and caspase-3 activation.
Positive_regulation (activation) of caspase-3 in neurons associated with dynorphin and apoptosis
10) Confidence 0.69 Published 2003 Journal Neuroscience Section Title Doc Link 14643768 Disease Relevance 0.47 Pain Relevance 0.77
Moreover, the increased cell death is mediated by mu-opioid receptors and accompanied by the activation of caspase-3.
Positive_regulation (activation) of caspase-3 associated with mu opioid receptor and death
11) Confidence 0.67 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15217373 Disease Relevance 1.19 Pain Relevance 0.66
Twelve hours later, dramatically increased cleaved caspase-3 and single-strand DNA immunoreactivity were detected in the pup brains.
Positive_regulation (increased) of caspase-3 in brains
12) Confidence 0.67 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18852026 Disease Relevance 0.46 Pain Relevance 0.08
However, paracetamol-induced apoptosis is a caspase-dependent process that involves activation of caspase-9 and caspase-3 in the absence of cytosolic cytochrome c or Smac/DIABLO.
Positive_regulation (activation) of caspase-3 associated with paracetamol and apoptosis
13) Confidence 0.67 Published 2004 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 14747384 Disease Relevance 1.10 Pain Relevance 0.92
Interestingly, DP thymocyte depletion inside TNCs is dependent on androgens, and the intracellular thymocyte pathway of cell death leads to activation of caspase-3 [28].
Positive_regulation (activation) of caspase-3 in thymocyte associated with death
14) Confidence 0.67 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 1.00 Pain Relevance 0.04
Treatment with darbufelone also induced apoptosis by activating caspase-3 and caspase-8.
Positive_regulation (activating) of caspase-3
15) Confidence 0.67 Published 2010 Journal Cancer Chemother. Pharmacol. Section Body Doc Link 20352217 Disease Relevance 0.16 Pain Relevance 0
Postsynaptic DA receptor supersensitivity in mice displaying a morphine-induced CPP was evidenced by the enhanced response in ambulatory activity to the DA agonist.
Positive_regulation (induced) of CPP associated with dopamine, agonist and morphine
16) Confidence 0.66 Published 1999 Journal J Ethnopharmacol Section Abstract Doc Link 10432204 Disease Relevance 0 Pain Relevance 0.93
The oral administration of velvet antler water extract (VAWE) from Cerrus elaphus, prior to the morphine treatment in mice inhibited the development of morphine-induced CPP and postsynaptic DA receptor supersensitivity.
Positive_regulation (induced) of CPP associated with dopamine and morphine
17) Confidence 0.66 Published 1999 Journal J Ethnopharmacol Section Abstract Doc Link 10432204 Disease Relevance 0 Pain Relevance 1.04
N(2)O did not induce CPP but impaired the acquisition of morphine-induced CPP and blocked the expression of cocaine- and morphine-induced CPP.
Positive_regulation (induced) of CPP associated with cocaine and morphine
18) Confidence 0.61 Published 2007 Journal Neuroscience Section Abstract Doc Link 17905521 Disease Relevance 0.37 Pain Relevance 0.83
However, other studies have reported either no difference or opposite strain differences for cocaine- and morphine-induced CPP as well as for the locomotor effects of these drugs, suggesting that amphetamine-related behavioral phenotypes might depend on a specific pharmacological action of the psychostimulant.
Neg (no) Positive_regulation (induced) of CPP associated with sprains and strains, morphine and cocaine
19) Confidence 0.60 Published 2005 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 15864555 Disease Relevance 0.35 Pain Relevance 0.15
Clonidine and prazosin reversed, while yohimbine decreased morphine-induced CPP.
Positive_regulation (induced) of CPP associated with morphine and clonidine
20) Confidence 0.60 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12213541 Disease Relevance 0 Pain Relevance 1.41

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