INT65602

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Context Info
Confidence 0.42
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.52
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Neurod1) nucleocytoplasmic transport (Neurod1) nucleus (Neurod1)
DNA binding (Neurod1) transcription factor binding (Neurod1) cytoplasm (Neurod1)
Anatomy Link Frequency
neuronal 1
liver 1
brain 1
Neurod1 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 141 98.80 Very High Very High Very High
halothane 2 98.12 Very High Very High Very High
anesthesia 5 97.72 Very High Very High Very High
agonist 1 95.20 Very High Very High Very High
Catecholamine 1 92.92 High High
Nicotine 6 92.00 High High
Pain 5 90.60 High High
qutenza 2 87.48 High High
Neurotransmitter 4 85.16 High High
Antinociceptive 2 83.68 Quite High
Disease Link Frequency Relevance Heat
Disease 2 99.20 Very High Very High Very High
Ganglion Cysts 155 98.80 Very High Very High Very High
Liver Disease 1 97.80 Very High Very High Very High
Targeted Disruption 63 97.28 Very High Very High Very High
Stress 7 96.84 Very High Very High Very High
Repression 11 96.24 Very High Very High Very High
Injury 3 93.56 High High
Pain 5 90.60 High High
Neurodegenerative Disease 9 81.80 Quite High
Hepatitis 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To identify the particular subunits involved in this process, we generated mice lacking the alpha4 subunit of the neuronal nAChR by homologous recombination techniques and studied these together with previously generated mutant mice lacking the beta2 nAChR subunit.
Negative_regulation (lacking) of beta2 in neuronal
1) Confidence 0.42 Published 1999 Journal Nature Section Abstract Doc Link 10235262 Disease Relevance 0.09 Pain Relevance 0.60
Hence, strategies reducing the activity of peptidergic sensory nerve fibres or stimulating beta2-adrenoreceptors, may be of benefit in immune-mediated liver disease.
Negative_regulation (reducing) of beta2 in liver associated with liver disease
2) Confidence 0.42 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10337911 Disease Relevance 0.61 Pain Relevance 0.18
In support of previous findings by others, it was found that blockade of beta-1 and beta-2 receptors by propranolol delayed arousal from halothane anesthesia and that this effect was attributable to blockade of beta-1 receptors because it was duplicated by betaxolol but not by ICI 118,551.
Negative_regulation (blockade) of beta-2 associated with anesthesia and halothane
3) Confidence 0.41 Published 1996 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8870048 Disease Relevance 0.45 Pain Relevance 0.43
This group contains many transcription factors, including the known directly repressed targets Neurod1 and Neurod4 [14].
Negative_regulation (repressed) of Neurod1
4) Confidence 0.38 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.65 Pain Relevance 0.03
However, in recent studies we have used locus-ChIP to demonstrate that Brn3a is a direct repressor of NeuroD1 and NeuroD4 in the embryonic TG [[27] in press], as well as a negative modulator of its own expression [32,33].
Negative_regulation (repressor) of NeuroD1 associated with trigeminal ganglion
5) Confidence 0.29 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.54 Pain Relevance 0.20
Specificity was demonstrated by signal loss in beta2(-/-) and alpha4(-/-) brain sections, respectively.
Negative_regulation (loss) of beta2 in brain
6) Confidence 0.28 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17072836 Disease Relevance 0 Pain Relevance 0.06
However, these studies evaluated anaesthetic effects in point mutation mice in which the effect of etomidate was decreased, but not abolished, at the beta2 subunit.
Neg (not) Negative_regulation (abolished) of beta2
7) Confidence 0.19 Published 2004 Journal Neuroreport Section Abstract Doc Link 15232301 Disease Relevance 0.18 Pain Relevance 0.04

General Comments

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