INT65603

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Context Info
Confidence 0.41
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.32
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SRI) transport (SRI) plasma membrane (SRI)
intracellular (SRI) cytoplasm (SRI)
Anatomy Link Frequency
SCN 4
neurons 2
SRI (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 6 99.48 Very High Very High Very High
5HT 13 99.34 Very High Very High Very High
antagonist 1 92.56 High High
tetrodotoxin 3 89.04 High High
anesthesia 1 85.92 High High
gABA 1 85.84 High High
Hippocampus 4 85.44 High High
Glutamate 6 84.72 Quite High
drug abuse 1 83.92 Quite High
Serotonin 8 83.48 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 9 99.52 Very High Very High Very High
Disease 11 99.44 Very High Very High Very High
Dementia 88 98.46 Very High Very High Very High
Apoptosis 13 96.56 Very High Very High Very High
Aging 5 92.16 High High
Ganglion Cysts 4 88.00 High High
Drug Dependence 3 83.92 Quite High
Shock 3 81.84 Quite High
Increased Venous Pressure Under Development 4 81.12 Quite High
Heart Rate Under Development 1 67.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is good reason to expect impairment in circadian rhythms in patients with dementia, particularly those with Alzheimer’s disease (AD), as circadian rhythms are generated in the suprachiasmatic nucleus (SCN) and there is often degeneration of the neurons of the SCN in this population (Swaab et al 1985).
Positive_regulation (generated) of SCN in SCN associated with dementia and disease
1) Confidence 0.41 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413196 Disease Relevance 0.79 Pain Relevance 0.09
Using laser Doppler flowmetry (LDF) to measure ChBF, we found that electrical activation of the contralateral SCN by 100-Hz anodal pulse trains yielded increases in ChBF that were stimulus related and proportional to the stimulating current.
Positive_regulation (activation) of SCN in SCN
2) Confidence 0.40 Published 1996 Journal Vis. Neurosci. Section Abstract Doc Link 8870223 Disease Relevance 0.16 Pain Relevance 0.07
Since the EWM receives input from the contralateral suprachiasmatic nucleus (SCN), which in turn receives contralateral retinal input, the present study sought to determine if activation of the SCN by microstimulation or by retinal illumination of the contralateral eye would also yield increases in ChBF in that same eye.
Spec (determine) Positive_regulation (activation) of SCN in suprachiasmatic nucleus
3) Confidence 0.40 Published 1996 Journal Vis. Neurosci. Section Abstract Doc Link 8870223 Disease Relevance 0.15 Pain Relevance 0.05
In addition, it was found that the administration of higher concentrations of 5HT can increase Ca2+ in at least a subpopulation of SCN neurons.
Positive_regulation (subpopulation) of SCN in neurons associated with 5ht
4) Confidence 0.20 Published 1999 Journal J. Biol. Rhythms Section Abstract Doc Link 10511003 Disease Relevance 0 Pain Relevance 0.95
Investigations into the function of these genes in the response of the SCN to photic stimuli have been extremely limited.
Positive_regulation (response) of SCN
5) Confidence 0.03 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0.17 Pain Relevance 0.04
In contrast, the known functions of Gadd45b and Tiparp suggest potential connections to SCN function.
Positive_regulation (connections) of SCN
6) Confidence 0.03 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0.27 Pain Relevance 0.04
The expression of c-fos protein is commonly used as a marker for light-like activation of neurons in the SCN.
Positive_regulation (activation) of SCN in neurons
7) Confidence 0.03 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0.10 Pain Relevance 0
Moreover, mPer1 expression can be induced in the SCN by a brief light pulse during the dark phase [16].
Positive_regulation (induced) of SCN
8) Confidence 0.03 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0.31 Pain Relevance 0.54
However, receptor autoradiographic studies showed that fluoxetine prevents the age-related increase in SCN 5-HT(1B) receptors at ZT6, and decreases SCN 5-HT(1B) receptors in both ages at ZT13.
Positive_regulation (increase) of SCN in SCN associated with fluoxetine
9) Confidence 0.02 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525077 Disease Relevance 0.37 Pain Relevance 0.79

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