INT65627

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2011
Negated 2
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 7.82
Pain Relevance 10.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Kcna5) plasma membrane (Kcna5) transmembrane transport (Kcna5)
Anatomy Link Frequency
DRG 3
motor neurons 3
macrophages 1
sciatic nerves 1
L929 1
Kcna5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 66 100.00 Very High Very High Very High
qutenza 28 99.84 Very High Very High Very High
diclofenac 14 99.84 Very High Very High Very High
Sciatic nerve 8 97.32 Very High Very High Very High
Neuronal excitability 9 93.60 High High
rheumatoid arthritis 2 92.40 High High
Pain 22 90.44 High High
Spinal cord 15 90.44 High High
Neuropathic pain 16 89.40 High High
cINOD 2 88.76 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 117 100.00 Very High Very High Very High
Hypoxia 6 99.78 Very High Very High Very High
Neuropathic Pain 56 99.72 Very High Very High Very High
Diabetes Mellitus 6 99.12 Very High Very High Very High
Nervous System Injury 30 97.60 Very High Very High Very High
Rheumatoid Arthritis 2 92.40 High High
Autoimmune Disease 6 91.24 High High
INFLAMMATION 28 88.28 High High
Increased Venous Pressure Under Development 1 77.60 Quite High
Pain 21 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Axotomy significantly decreased Kv1.1, Kv1.2, Kv1.3 and Kv1.4 mRNA levels by approximately 35%, approximately 60%, approximately 40% and approximately 80%, respectively, but did not significantly change Kv1.5 or Kv1.6 mRNA levels.
Negative_regulation (decreased) of Kv1
1) Confidence 0.59 Published 2004 Journal Neuroscience Section Abstract Doc Link 14751280 Disease Relevance 0.55 Pain Relevance 0.44
Axotomy significantly decreased Kv1.1, Kv1.2, Kv1.3 and Kv1.4 mRNA levels by approximately 35%, approximately 60%, approximately 40% and approximately 80%, respectively, but did not significantly change Kv1.5 or Kv1.6 mRNA levels.
Negative_regulation (decreased) of Kv1
2) Confidence 0.59 Published 2004 Journal Neuroscience Section Abstract Doc Link 14751280 Disease Relevance 0.55 Pain Relevance 0.44
Axotomy significantly decreased Kv1.1, Kv1.2, Kv1.3 and Kv1.4 mRNA levels by approximately 35%, approximately 60%, approximately 40% and approximately 80%, respectively, but did not significantly change Kv1.5 or Kv1.6 mRNA levels.
Negative_regulation (decreased) of Kv1
3) Confidence 0.59 Published 2004 Journal Neuroscience Section Abstract Doc Link 14751280 Disease Relevance 0.55 Pain Relevance 0.44
However, after siRNA treatment, the firing threshold had values similar to those obtained after acute exposure to DTX-K, suggesting that the loss of Kv1.1 plays a critical role in setting this parameter of excitability.
Negative_regulation (loss) of Kv1
4) Confidence 0.57 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17855588 Disease Relevance 0 Pain Relevance 0.37
Quantitative RT-PCR analysis revealed that the mRNA levels of IA subunits, including Kv1.4, Kv3.4, Kv4.2, and Kv4.3, in the DRG were reduced approximately 50% in diabetic rats compared with those in control rats.
Negative_regulation (reduced) of Kv1 in DRG associated with dorsal root ganglion and diabetes mellitus
5) Confidence 0.52 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20557422 Disease Relevance 1.11 Pain Relevance 0.62
Axotomy significantly decreased Kv1.1, Kv1.2, Kv1.3 and Kv1.4 mRNA levels by approximately 35%, approximately 60%, approximately 40% and approximately 80%, respectively, but did not significantly change Kv1.5 or Kv1.6 mRNA levels.
Negative_regulation (decreased) of Kv1
6) Confidence 0.43 Published 2004 Journal Neuroscience Section Abstract Doc Link 14751280 Disease Relevance 0.55 Pain Relevance 0.44
We found that motor neurons are highly enriched in Kv1.5 and Kv1.6 mRNA and in Kv1.5 channel protein.
Negative_regulation (enriched) of Kv1 in motor neurons
7) Confidence 0.43 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8872310 Disease Relevance 0 Pain Relevance 0.83
We found that motor neurons are highly enriched in Kv1.5 and Kv1.6 mRNA and in Kv1.5 channel protein.
Negative_regulation (enriched) of Kv1 in motor neurons
8) Confidence 0.43 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8872310 Disease Relevance 0 Pain Relevance 0.82
We found that motor neurons are highly enriched in Kv1.5 and Kv1.6 mRNA and in Kv1.5 channel protein.
Negative_regulation (enriched) of Kv1 in motor neurons
9) Confidence 0.43 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8872310 Disease Relevance 0 Pain Relevance 0.83
Downregulation of Kv1.1 or Nav1.5 by RNA interference suppressed RGM-1 cell proliferation.
Negative_regulation (Downregulation) of Kv1
10) Confidence 0.34 Published 2006 Journal J. Cell. Physiol. Section Abstract Doc Link 16331678 Disease Relevance 0 Pain Relevance 0.08
While diclofenac inhibited Kv1.3 expression in activated macrophages and T-lymphocytes, Kv1.5 remained unaffected.
Neg (unaffected) Negative_regulation (unaffected) of Kv1 in T-lymphocytes associated with diclofenac
11) Confidence 0.32 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20488163 Disease Relevance 0.44 Pain Relevance 0.65
subunits, Kv1.4, 2.2, and 4.2 mRNAs are downregulated under neuropathic conditions involving the transection and CCI of sciatic nerves [15,16].
Negative_regulation (downregulated) of Kv1 in sciatic nerves associated with nervous system injury, neuropathic pain and sciatic nerve
12) Confidence 0.30 Published 2011 Journal Mol Pain Section Body Doc Link PMC3024960 Disease Relevance 1.14 Pain Relevance 0.81
Hypoxia failed to inhibit any Kv1 channel, but it inhibited Kv3.1b channels expressed in L929 cells, as shown by a reduction of whole-cell current and single-channel activity, without affecting unitary conductance.
Negative_regulation (inhibit) of Kv1 in L929 associated with hypoxia
13) Confidence 0.25 Published 2000 Journal Circ. Res. Section Abstract Doc Link 10720415 Disease Relevance 0.57 Pain Relevance 0.06
Dendrotoxin K (DTX(K)), a specific inhibitor of Kv1.1, reduced the DRG K(+) current at +20 mV by 34%, consistent with an important contribution of channels incorporating the Kv1.1 subunit to the delayed rectifier current.
Negative_regulation (inhibitor) of Kv1 in DRG associated with dorsal root ganglion
14) Confidence 0.16 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538804 Disease Relevance 0.58 Pain Relevance 0.41
BAB inhibits the Kv1.1 channels with an IC(50) value of 238 microM, similar to what was observed for the native DRG current.
Negative_regulation (inhibits) of Kv1 in DRG associated with dorsal root ganglion
15) Confidence 0.12 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538804 Disease Relevance 0.68 Pain Relevance 0.45
BAB seems to inhibit Kv1.1 by stabilizing closed conformations of the channel.
Negative_regulation (inhibit) of Kv1
16) Confidence 0.12 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538804 Disease Relevance 0.68 Pain Relevance 0.53
While diclofenac inhibited Kv1.3 expression in activated macrophages and T-lymphocytes, Kv1.5 remained unaffected.
Neg (unaffected) Negative_regulation (unaffected) of Kv1 in macrophages associated with diclofenac
17) Confidence 0.11 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20488163 Disease Relevance 0.44 Pain Relevance 0.65
Although Kv1.3 block may contribute to reducing CCE by changes in membrane potential, block of I(CRAC) is the primary mechanism by which capsaicin reduces CCE.
Negative_regulation (block) of Kv1 associated with qutenza
18) Confidence 0.05 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11561085 Disease Relevance 0 Pain Relevance 0.97
The major voltage-gated K+ channel in Jurkat cells, Kv1.3, is also blocked by capsaicin.
Negative_regulation (blocked) of Kv1 associated with qutenza
19) Confidence 0.05 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11561085 Disease Relevance 0 Pain Relevance 0.96

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