INT65628

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Context Info
Confidence 0.61
First Reported 1996
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.66
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Kcna5) plasma membrane (Kcna5) transmembrane transport (Kcna5)
Anatomy Link Frequency
spinal cord 6
Kcna5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 15 100.00 Very High Very High Very High
Spinal cord 15 99.52 Very High Very High Very High
Opioid 6 96.24 Very High Very High Very High
opiate 12 94.12 High High
dorsal root ganglion 7 91.04 High High
midbrain 2 86.08 High High
Dopamine 3 85.36 High High
addiction 8 85.28 High High
tolerance 6 84.68 Quite High
Lasting pain 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 1 99.56 Very High Very High Very High
Alzheimer's Dementia 4 98.20 Very High Very High Very High
Drug Induced Neurotoxicity 1 96.88 Very High Very High Very High
Hypoxia 6 94.96 High High
Neuroblastoma 1 93.84 High High
Ganglion Cysts 8 91.04 High High
Disease 17 90.72 High High
Apoptosis 165 78.60 Quite High
Death 31 77.84 Quite High
Pain 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we focused on the effect of chronic morphine exposure on voltage-dependent Shaker-related Kv1.5 and Kv1.6 K+ channel gene expression and on Kv1.5 protein levels in the rat spinal cord.
Regulation (effect) of Gene_expression (expression) of Kv1 in spinal cord associated with spinal cord and morphine
1) Confidence 0.61 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8872310 Disease Relevance 0 Pain Relevance 0.80
In this study, we focused on the effect of chronic morphine exposure on voltage-dependent Shaker-related Kv1.5 and Kv1.6 K+ channel gene expression and on Kv1.5 protein levels in the rat spinal cord.
Regulation (effect) of Gene_expression (levels) of Kv1 in spinal cord associated with spinal cord and morphine
2) Confidence 0.45 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8872310 Disease Relevance 0 Pain Relevance 0.80
In this study, we focused on the effect of chronic morphine exposure on voltage-dependent Shaker-related Kv1.5 and Kv1.6 K+ channel gene expression and on Kv1.5 protein levels in the rat spinal cord.
Regulation (effect) of Gene_expression (expression) of Kv1 in spinal cord associated with spinal cord and morphine
3) Confidence 0.45 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8872310 Disease Relevance 0 Pain Relevance 0.80
Up-regulation of Kv1.4, Kv2.1 and Kv4.2 expression both mRNA and protein levels is observed in amyloid peptide (25-35) -induced neurotoxicity [103].
Regulation (regulation) of Gene_expression (expression) of Kv1 associated with drug induced neurotoxicity and alzheimer's dementia
4) Confidence 0.20 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 1.04 Pain Relevance 0.15
To further investigate the mechanism of BAB inhibition, we examined its effect on Kv1.1 channels heterologously expressed in mammalian tsA201 cells.
Spec (examined) Regulation (effect) of Gene_expression (expressed) of Kv1
5) Confidence 0.17 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538804 Disease Relevance 0.63 Pain Relevance 0.42

General Comments

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