INT65630

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Context Info
Confidence 0.62
First Reported 1996
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 11
Total Number 14
Disease Relevance 6.61
Pain Relevance 7.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Kcna5) plasma membrane (Kcna5) transmembrane transport (Kcna5)
Anatomy Link Frequency
spinal cord 2
DRG 2
sensory neurons 1
neurons 1
Kcna5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
diclofenac 14 100.00 Very High Very High Very High
Morphine 10 100.00 Very High Very High Very High
potassium channel 18 99.98 Very High Very High Very High
Neuronal excitability 2 99.84 Very High Very High Very High
Neuropathic pain 5 99.28 Very High Very High Very High
Spinal cord 10 98.84 Very High Very High Very High
dorsal root ganglion 49 97.76 Very High Very High Very High
Sciatic nerve 4 96.36 Very High Very High Very High
Opioid 4 96.24 Very High Very High Very High
hyperexcitability 4 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 1 99.56 Very High Very High Very High
Neuropathic Pain 5 99.28 Very High Very High Very High
Ganglion Cysts 55 97.76 Very High Very High Very High
Alzheimer's Dementia 4 97.00 Very High Very High Very High
Drug Induced Neurotoxicity 1 95.68 Very High Very High Very High
Injury 10 95.64 Very High Very High Very High
Hypoxia 6 94.96 High High
Neuroblastoma 1 93.84 High High
Disease 17 88.32 High High
Apoptosis 165 78.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Axotomy significantly decreased Kv1.1, Kv1.2, Kv1.3 and Kv1.4 mRNA levels by approximately 35%, approximately 60%, approximately 40% and approximately 80%, respectively, but did not significantly change Kv1.5 or Kv1.6 mRNA levels.
Neg (not) Regulation (change) of Kv1
1) Confidence 0.62 Published 2004 Journal Neuroscience Section Abstract Doc Link 14751280 Disease Relevance 0.61 Pain Relevance 0.46
Axotomy significantly decreased Kv1.1, Kv1.2, Kv1.3 and Kv1.4 mRNA levels by approximately 35%, approximately 60%, approximately 40% and approximately 80%, respectively, but did not significantly change Kv1.5 or Kv1.6 mRNA levels.
Neg (not) Regulation (change) of Kv1
2) Confidence 0.62 Published 2004 Journal Neuroscience Section Abstract Doc Link 14751280 Disease Relevance 0.61 Pain Relevance 0.46
We examined the effects of axotomy on mRNA levels for various Kv1 family subunits and voltage-gated K+ currents in L4-L5 DRG neurons from sham-operated and sciatic nerve-transected rats.
Spec (examined) Regulation (effects) of Kv1 in neurons associated with dorsal root ganglion and sciatic nerve
3) Confidence 0.62 Published 2004 Journal Neuroscience Section Abstract Doc Link 14751280 Disease Relevance 0.52 Pain Relevance 0.44
Kv1.4 and 1.6 immunostaining were not altered by axotomy, and Kv1.5 immunoreactivity was low in both control and axotomized DRG neurons.
Neg (not) Regulation (altered) of Kv1 in DRG associated with dorsal root ganglion
4) Confidence 0.61 Published 1999 Journal Muscle Nerve Section Abstract Doc Link 10204786 Disease Relevance 0.92 Pain Relevance 0.78
In this study, we focused on the effect of chronic morphine exposure on voltage-dependent Shaker-related Kv1.5 and Kv1.6 K+ channel gene expression and on Kv1.5 protein levels in the rat spinal cord.
Regulation (voltage-dependent) of Kv1 in spinal cord associated with spinal cord and morphine
5) Confidence 0.45 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8872310 Disease Relevance 0 Pain Relevance 0.79
Manipulation of the potassium channel Kv1.1 and its effect on neuronal excitability in rat sensory neurons.
Regulation (effect) of Kv1 in sensory neurons associated with neuronal excitability and potassium channel
6) Confidence 0.38 Published 2007 Journal J. Neurophysiol. Section Title Doc Link 17855588 Disease Relevance 0 Pain Relevance 0.45
In this study, we focused on the effect of chronic morphine exposure on voltage-dependent Shaker-related Kv1.5 and Kv1.6 K+ channel gene expression and on Kv1.5 protein levels in the rat spinal cord.
Regulation (effect) of Kv1 in spinal cord associated with spinal cord and morphine
7) Confidence 0.27 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8872310 Disease Relevance 0 Pain Relevance 0.80
WIN 17317-3 lacks selectivity for the Kv1.3 channels, its postulated target for immunosuppression.
Spec (postulated) Regulation (target) of Kv1
8) Confidence 0.27 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11779036 Disease Relevance 0.07 Pain Relevance 0.10
Because Kv1.3 is a very good target for autoimmune therapies, the effects of diclofenac on Kv1.3 are of high pharmacological relevance.
Regulation (target) of Kv1 associated with diclofenac
9) Confidence 0.20 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20488163 Disease Relevance 0.35 Pain Relevance 0.57
Because Kv1.3 is a very good target for autoimmune therapies, the effects of diclofenac on Kv1.3 are of high pharmacological relevance.
Regulation (effects) of Kv1 associated with diclofenac
10) Confidence 0.17 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20488163 Disease Relevance 0.33 Pain Relevance 0.56
To further investigate the mechanism of BAB inhibition, we examined its effect on Kv1.1 channels heterologously expressed in mammalian tsA201 cells.
Spec (examined) Regulation (effect) of Kv1
11) Confidence 0.12 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538804 Disease Relevance 0.62 Pain Relevance 0.42
No significant changes in Kv 1.5, 1.6, 2.1, 3.1, 3.2, 3.5, and 4.1 mRNA levels were detectable in the ipsilateral DRG at both days.
Neg (No) Regulation (changes) of Kv 1.5 in DRG associated with dorsal root ganglion
12) Confidence 0.10 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399117 Disease Relevance 0.89 Pain Relevance 0.72
Up-regulation of Kv1.4, Kv2.1 and Kv4.2 expression both mRNA and protein levels is observed in amyloid peptide (25-35) -induced neurotoxicity [103].
Regulation (regulation) of Kv1 associated with drug induced neurotoxicity and alzheimer's dementia
13) Confidence 0.09 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 1.02 Pain Relevance 0.15
Coexpression with the Kv beta 1 subunit induces rapid inactivation and reduces the BAB sensitivity of Kv1.1.
Regulation (sensitivity) of Kv1
14) Confidence 0.07 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538804 Disease Relevance 0.67 Pain Relevance 0.54

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