INT65638

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Context Info
Confidence 0.58
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 7.86
Pain Relevance 11.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Il1rl1) extracellular space (Il1rl1) extracellular region (Il1rl1)
plasma membrane (Il1rl1) intracellular (Il1rl1) molecular_function (Il1rl1)
Anatomy Link Frequency
spinal 6
neuronal 3
horn 2
neuron 2
dorsal horn 2
Il1rl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 8 99.98 Very High Very High Very High
Cannabinoid 46 99.82 Very High Very High Very High
Pain 44 99.80 Very High Very High Very High
Inflammation 44 99.64 Very High Very High Very High
Analgesic 24 99.30 Very High Very High Very High
nociceptor 9 98.96 Very High Very High Very High
Dorsal horn 9 98.28 Very High Very High Very High
antagonist 12 95.72 Very High Very High Very High
Sciatic nerve 2 95.48 Very High Very High Very High
ketamine 3 94.52 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 8 100.00 Very High Very High Very High
Hypothermia 7 99.98 Very High Very High Very High
Pain 26 99.80 Very High Very High Very High
INFLAMMATION 31 99.64 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 96.80 Very High Very High Very High
Nociception 18 95.52 Very High Very High Very High
Drug Dependence 1 94.44 High High
Hyperalgesia 17 92.20 High High
Neuropathic Pain 32 91.28 High High
Catalepsy 4 91.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, methoxyflurane and hypothermia blocked the appearance of the Fos protein.
Negative_regulation (blocked) of Gene_expression (appearance) of Fos protein associated with hypothermia
1) Confidence 0.58 Published 1996 Journal Dev Psychobiol Section Abstract Doc Link 8872423 Disease Relevance 0.28 Pain Relevance 0.40
In immunocytochemical studies, AM1241 suppressed spinal Fos protein expression, a marker of neuronal activity, in the carrageenan model of inflammation.
Negative_regulation (suppressed) of Gene_expression (expression) of Fos protein in neuronal associated with inflammation
2) Confidence 0.55 Published 2003 Journal Neuroscience Section Abstract Doc Link 12809695 Disease Relevance 1.04 Pain Relevance 1.03
The suppression of carrageenan-evoked Fos protein expression induced by AM1241 was blocked by coadministration of SR144528 in all spinal laminae.
Negative_regulation (blocked) of Gene_expression (expression) of Fos protein in spinal
3) Confidence 0.55 Published 2003 Journal Neuroscience Section Abstract Doc Link 12809695 Disease Relevance 0.89 Pain Relevance 1.08
A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.
Negative_regulation (suppresses) of Gene_expression (expression) of fos protein in spinal associated with pain, inflammation, analgesic and cannabinoid
4) Confidence 0.55 Published 2003 Journal Neuroscience Section Title Doc Link 12617970 Disease Relevance 0.79 Pain Relevance 1.57
This study examined the role of c-fos in the acquisition and expression of the conditioned place paradigm (CPP) in the rat by suppressing Fos protein expression with c-fos antisense oligodeoxynucleotides (ODNs).
Negative_regulation (suppressing) of Gene_expression (expression) of Fos protein
5) Confidence 0.43 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10998122 Disease Relevance 0.09 Pain Relevance 0.82
AM1241 suppressed carrageenan-evoked Fos protein expression in the superficial and neck region of the dorsal horn but not in the nucleus proprius or the ventral horn.
Negative_regulation (suppressed) of Gene_expression (expression) of Fos protein in horn associated with dorsal horn
6) Confidence 0.40 Published 2003 Journal Neuroscience Section Abstract Doc Link 12809695 Disease Relevance 1.01 Pain Relevance 1.13
Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.
Negative_regulation (suppresses) of Gene_expression (expression) of fos protein in spinal associated with pain, inflammation, analgesic and cannabinoid
7) Confidence 0.40 Published 2003 Journal Neuroscience Section Title Doc Link 12809695 Disease Relevance 1.06 Pain Relevance 1.71
WIN55,212-3, the enantiomer of the active compound, also failed to suppress carrageenan-evoked Fos protein expression.
Neg (failed) Negative_regulation (suppress) of Gene_expression (expression) of Fos protein
8) Confidence 0.40 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617970 Disease Relevance 0.79 Pain Relevance 1.15
The cannabinoid agonist suppressed formalin-evoked Fos protein expression, a marker of neuronal activity, in the lumbar dorsal horn of sham-operated rats, but no suppression was observed in lesioned rats.
Negative_regulation (suppressed) of Gene_expression (expression) of Fos protein in dorsal horn associated with cannabinoid, dorsal horn and agonist
9) Confidence 0.35 Published 2003 Journal Brain Res. Section Abstract Doc Link 14499961 Disease Relevance 0.55 Pain Relevance 1.20
It has been shown in the rat that N-methyl-D-aspartate (NMDA) receptor blockade causes a reduction in Fos protein expression after generalised meningeal irritation.
Negative_regulation (reduction) of Gene_expression (expression) of Fos protein
10) Confidence 0.34 Published 2001 Journal Brain Res. Section Abstract Doc Link 11430892 Disease Relevance 0.09 Pain Relevance 0.20
Neuronal expression of Fos protein in the brain after intravenous injection of gastrin in rats.
Negative_regulation (injection) of in Neuronal Gene_expression (expression) of Fos protein in brain
11) Confidence 0.08 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 11755239 Disease Relevance 0 Pain Relevance 0.22
They also showed that continuous methylprednisolone infusion partially reversed nerve injury-evoked Fos protein expression in the dorsal horns, suggesting that glucocorticoids can inhibit spinal neuron hyperactivity induced by chronic sciatic nerve transaction.
Negative_regulation (reversed) of Gene_expression (expression) of Fos protein in neuron associated with nervous system injury, sciatic nerve and attention deficit hyperactivity disorder
12) Confidence 0.01 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935977 Disease Relevance 1.25 Pain Relevance 1.19

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