INT65640

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Context Info
Confidence 0.42
First Reported 1996
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 2.16
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
coronary sinus 4
nerve 2
Edn1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 2 100.00 Very High Very High Very High
Endogenous opioid 1 100.00 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 6 97.56 Very High Very High Very High
narcan 3 97.28 Very High Very High Very High
antagonist 1 95.80 Very High Very High Very High
cytokine 13 92.72 High High
guanethidine 1 92.64 High High
Inflammation 18 91.52 High High
substance P 10 86.16 High High
Calcitonin gene-related peptide 5 81.20 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 4 100.00 Very High Very High Very High
Blister 4 99.68 Very High Very High Very High
Stress 10 92.84 High High
INFLAMMATION 21 91.52 High High
Diabetes Mellitus 50 91.36 High High
Coronary Artery Disease 13 75.00 Quite High
Stable Angina Pectoris 2 75.00 Quite High
Atherosclerotic Plaque 2 75.00 Quite High
Sciatic Neuropathy 1 75.00 Quite High
Insulin Resistance 7 72.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No changes were found in the coronary sinus; these results suggest ET-1 release from the plaque rather than an ischemia/reperfusion-related production from the distal myocardium.
Positive_regulation (production) of Localization (release) of ET-1 in coronary sinus associated with ischemia
1) Confidence 0.42 Published 1999 Journal Am. J. Cardiol. Section Abstract Doc Link 10569670 Disease Relevance 0.42 Pain Relevance 0.25
No changes were found in the coronary sinus; these results suggest ET-1 release from the plaque rather than an ischemia/reperfusion-related production from the distal myocardium.
Spec (suggest) Positive_regulation (suggest) of Localization (release) of ET-1 in coronary sinus associated with ischemia
2) Confidence 0.42 Published 1999 Journal Am. J. Cardiol. Section Abstract Doc Link 10569670 Disease Relevance 0.42 Pain Relevance 0.25
In healthy people, insulin infusion results in the release of both NO and ET-1 in adequate concentrations to ensure an appropriate balance for maintaining vascular tone.
Positive_regulation (results) of Localization (release) of ET-1
3) Confidence 0.08 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.85 Pain Relevance 0.25
Possible activation of endogenous opioids and/or the release of endothelin due to blister induction in nerve lesioned rats was examined using naloxone and the endothelin receptor antagonist, BQ-123, respectively.
Spec (Possible) Positive_regulation (activation) of Localization (release) of endothelin in nerve associated with antagonist, narcan, endogenous opioid and blister
4) Confidence 0.01 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8872510 Disease Relevance 0.48 Pain Relevance 0.72

General Comments

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