INT6565

Context Info Confidence 0.70 First Reported 1987 Last Reported 2001 Negated 0 Speculated 1 Reported most in Abstract Documents 14 Total Number 16 Disease Relevance 4.04 Pain Relevance 6.76

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)

Anatomy Link Frequency plasma 17 kidney 3 blood 2 body 2 urine 2 Nppa (Rattus norvegicus)

Pain Link Frequency Relevance Heat Clonidine 37 99.98 Morphine 31 99.98 agonist 11 99.96 opiate 3 99.28 antagonist 6 99.00 Dynorphin 6 97.56 opioid receptor 10 97.08 narcan 8 96.28 Catecholamine 2 89.00 anesthesia 1 87.48

Disease Link Frequency Relevance Heat Body Weight 6 100.00 Pressure And Volume Under Development 2 98.24 Diuresis 16 97.92 Natriuresis 44 96.48 Hypertension 4 96.20 Sprains And Strains 1 88.64 Pressure Volume 2 Under Development 1 85.84 Myocardial Infarction 10 80.72 Shock 1 70.20 Heart Rate Under Development 1 67.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Clonidine, an alpha 2-adrenergic agonist, induced a marked, dose-related increase of plasma IR-ANF in normally-hydrated rats.

Positive_regulation (induced) of Positive_regulation (increase) of ANF in plasma associated with agonist and clonidine

1) Confidence 0.70 Published 1987 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3030313 Disease Relevance 0.07 Pain Relevance 0.59

A short, transient increase in blood pressure, occurred 2-5 min after morphine administration, but it is unlikely that this increase accounted for the increase in plasma ANF.

Positive_regulation (accounted) of Positive_regulation (increase) of ANF in blood associated with pressure and volume under development and morphine

2) Confidence 0.50 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8223938 Disease Relevance 0.38 Pain Relevance 0.67

The quaternary antagonist N-methylnaltrexone (1 mg/kg) failed to block the fentanyl-induced increase of ANF, suggesting that opiates bring about their action on ANF via a central mechanism.

Positive_regulation (fentanyl-induced) of Positive_regulation (increase) of ANF associated with antagonist and opiate

3) Confidence 0.50 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2961585 Disease Relevance 0.15 Pain Relevance 0.54

These renal responses were associated with increased plasma ANF (59 +/- 7 vs. 810 +/- 28 pg/ml, P < .001, n = 12), measured 10 min after ST-91 (250 micrograms/rat), which remained elevated for at least 1 h (P < .01, n = 6).

Positive_regulation (increased) of Positive_regulation (increased) of ANF in plasma

4) Confidence 0.50 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9152372 Disease Relevance 0.30 Pain Relevance 0.44

Morphine induced a transient, dose-dependent reduction in blood pressure (from 114+/-1 to 71+/-6 mm Hg at 10.0 mg/kg body weight) and a dose-dependent elevation of plasma ANF.

Positive_regulation (induced) of Positive_regulation (elevation) of ANF in body associated with body weight and morphine

5) Confidence 0.50 Published 1997 Journal Kidney Blood Press. Res. Section Abstract Doc Link 9192906 Disease Relevance 0.44 Pain Relevance 0.59

These results demonstrate that at higher fentanyl doses, the increased ANP release is mediated primarily by elevation of right atrial pressure.

Positive_regulation (mediated) of Positive_regulation (increased) of ANP

6) Confidence 0.50 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2143537 Disease Relevance 0.25 Pain Relevance 0.11

Clonidine injection in a dose of 50 micrograms caused a marked increase of plasma IR-ANF from 34.0 +/- 7.0 pg/ml (mean +/- S.E.M.) to 457.1 +/- 66.3 pg/ml.

Positive_regulation (caused) of Positive_regulation (increase) of ANF in plasma associated with clonidine

7) Confidence 0.47 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3035429 Disease Relevance 0.15 Pain Relevance 0.55

WI induced a significant increase of plasma ANP in both examined groups which became markedly reduced after blockade of opioid receptors by naloxone.

Spec (examined) Positive_regulation (induced) of Spec (examined) Positive_regulation (increase) of ANP in plasma associated with narcan and opioid receptor

8) Confidence 0.45 Published 1992 Journal Clin. Nephrol. Section Abstract Doc Link 1330391 Disease Relevance 0.47 Pain Relevance 0.47

In normally-hydrated rats clonidine produced a marked elevation of plasma IR-ANF from 40.5 +/- 4.6 pg/ml to 1064 +/- 22 pg/ml (mean +/- SEM) and sodium excretion from 73.3 +/- 6.8 microEq to 723.4 +/- 62.3 microEq.

Positive_regulation (produced) of Positive_regulation (elevation) of IR-ANF in plasma associated with clonidine

9) Confidence 0.44 Published 1988 Journal Peptides Section Abstract Doc Link 2856643 Disease Relevance 0.35 Pain Relevance 0.61

In normally-hydrated rats clonidine produced a marked elevation of plasma IR-ANF from 40.5 +/- 4.6 pg/ml to 1064 +/- 22 pg/ml (mean +/- SEM) and sodium excretion from 73.3 +/- 6.8 microEq to 723.4 +/- 62.3 microEq.

Positive_regulation (produced) of Positive_regulation (elevation) of IR-ANF in plasma associated with clonidine

10) Confidence 0.44 Published 1988 Journal Peptides Section Abstract Doc Link 2856643 Disease Relevance 0.35 Pain Relevance 0.61

However, it has a special role to play, because it is a rapid release hormone: rapid vascular filling leads to an increase in ANF in less than 1 minute, with a parallel increase in diuresis.

Positive_regulation (leads) of Positive_regulation (increase) of ANF associated with diuresis

11) Confidence 0.41 Published 1990 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 2141971 Disease Relevance 0.24 Pain Relevance 0.25

MS-induced elevations of plasma ANP levels may be dependent on an intact autonomic nervous system.

Positive_regulation (induced) of Positive_regulation (elevations) of plasma ANP in plasma associated with morphine

12) Confidence 0.40 Published 1988 Journal Life Sci. Section Abstract Doc Link 2901019 Disease Relevance 0.07 Pain Relevance 1.24

RESULTS: A single administration of ONO-9902 inhibited the plasma and kidney NEP activities and thereby further augmented the elevation of plasma ANP concentration in rats with CAL at the 1st week after the operation.

Positive_regulation (augmented) of Positive_regulation (elevation) of ANP in kidney

13) Confidence 0.35 Published 2001 Journal Cardiovasc. Res. Section Body Doc Link 11476752 Disease Relevance 0.08 Pain Relevance 0

Progesterone therapy caused an increase in plasma ANF and osmolality levels and the AVP threshold and a decrease in AVP levels and sensitivity and urinary cyclic nucleotide levels.

Positive_regulation (caused) of Positive_regulation (increase) of ANF in plasma

14) Confidence 0.27 Published 1997 Journal Clin Invest Med Section Body Doc Link 9258576 Disease Relevance 0 Pain Relevance 0

RESULTS: A single administration of ONO-9902 inhibited the plasma and kidney NEP activities and thereby further augmented the elevation of plasma ANP concentration in rats with CAL at the 1st week after the operation.

Positive_regulation (augmented) of in plasma Positive_regulation (elevation) of ANP in kidney

15) Confidence 0.12 Published 2001 Journal Cardiovasc. Res. Section Body Doc Link 11476752 Disease Relevance 0.08 Pain Relevance 0

After CPB ended, urine flow and sodium excretion increased in conjunction with increased alpha-ANF and normal ADH.

Positive_regulation (increased) of Positive_regulation (increased) of alpha-ANF in urine

16) Confidence 0.04 Published 1989 Journal J. Thorac. Cardiovasc. Surg. Section Abstract Doc Link 2811428 Disease Relevance 0.65 Pain Relevance 0.09

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