INT65659

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 4
Speculated 16
Reported most in Body
Documents 132
Total Number 151
Disease Relevance 69.56
Pain Relevance 15.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) DNA binding (STAT3) cytoplasm (STAT3)
signal transducer activity (STAT3) cell proliferation (STAT3) cytosol (STAT3)
Anatomy Link Frequency
myocardium 7
nucleus 4
cardiomyocytes 4
dendritic cells 3
brain 2
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 28 99.92 Very High Very High Very High
cytokine 1542 99.82 Very High Very High Very High
withdrawal 15 99.82 Very High Very High Very High
Opioid 11 99.82 Very High Very High Very High
Crohn's disease 258 99.52 Very High Very High Very High
mu opioid receptor 4 99.02 Very High Very High Very High
alcohol 62 98.98 Very High Very High Very High
Kinase C 18 98.62 Very High Very High Very High
Inflammation 1491 98.56 Very High Very High Very High
fibrosis 57 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 2874 100.00 Very High Very High Very High
Targeted Disruption 117 100.00 Very High Very High Very High
Hepatitis 34 100.00 Very High Very High Very High
Metastasis 498 99.90 Very High Very High Very High
Glioma 582 99.84 Very High Very High Very High
Glioblastoma 334 99.84 Very High Very High Very High
Rheumatoid Arthritis 274 99.84 Very High Very High Very High
Coronary Heart Disease 260 99.68 Very High Very High Very High
Infection 158 99.66 Very High Very High Very High
Apoptosis 795 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because constitutive activation of signal transducer and activator of transcription 3 (Stat3) has been linked to carcinogenesis of various tumors including head and neck SCCa, we studied whether sulindac treatment affects the Stat3 signaling pathway in oral SCCa cells.
Spec (whether) Positive_regulation (activation) of signal transducer and activator of transcription 3 in neck associated with cancer and skin cancer
1) Confidence 0.70 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.88 Pain Relevance 0.17
Because constitutive activation of signal transducer and activator of transcription 3 (Stat3) has been linked to carcinogenesis of various tumors including head and neck SCCa, we studied whether sulindac treatment affects the Stat3 signaling pathway in oral SCCa cells.
Spec (whether) Positive_regulation (activation) of Stat3 in neck associated with cancer and skin cancer
2) Confidence 0.70 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.88 Pain Relevance 0.17
Also, sulindac treatment exerted a significant time-dependent cell growth-inhibitory effect on oral SCCa cells under the same conditions shown to induce Stat3 down-modulation.
Positive_regulation (induce) of Stat3 associated with skin cancer
3) Confidence 0.70 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861373 Disease Relevance 0.76 Pain Relevance 0.14
OBJECTIVE: Constitutive activation of the signal transducer and activator of transcription 3 (Stat3) has been detected in various human cancers and has been linked to tumor development and progression.
Positive_regulation (activation) of Stat3 associated with cancer
4) Confidence 0.70 Published 2009 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 19272804 Disease Relevance 0.35 Pain Relevance 0.15
OBJECTIVE: Constitutive activation of the signal transducer and activator of transcription 3 (Stat3) has been detected in various human cancers and has been linked to tumor development and progression.
Positive_regulation (activation) of signal transducer and activator of transcription 3 associated with cancer
5) Confidence 0.70 Published 2009 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 19272804 Disease Relevance 0.35 Pain Relevance 0.15
The mu-opioid-induced activation of STAT3 is sensitive to receptor was further shown to pertussis toxin treatment and required JAK and Src tyrosine kinases, but not phosphatidylinositol 3-kinase.
Positive_regulation (activation) of STAT3 associated with bordatella infection and opioid
6) Confidence 0.68 Published 2004 Journal Neuroreport Section Abstract Doc Link 15194868 Disease Relevance 0.26 Pain Relevance 0.34
Here we demonstrated that activation of mu-opioid receptors in human neuroblastoma SH-SY5Y cells led to the activation of signal transducer and activator of transcription 3 (STAT3), a transcription factor central to the regulation of numerous biological processes.
Positive_regulation (activation) of STAT3 in SH-SY5Y associated with neuroblastoma and mu opioid receptor
7) Confidence 0.68 Published 2004 Journal Neuroreport Section Abstract Doc Link 15194868 Disease Relevance 0.26 Pain Relevance 0.33
on the sarcolemma, initiating the activation of the JAK/STAT3 signaling pathway [17], [26], [50].
Positive_regulation (activation) of STAT3
8) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.09 Pain Relevance 0.04
The activation of Janus-activated kinase 1 and c-Src, implicated in STAT3 activation, was also inhibited by the vanilloid, with no effect on extracellular signal-regulated kinase 1/2 activation.
Positive_regulation (activation) of STAT3
9) Confidence 0.65 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17505005 Disease Relevance 0.07 Pain Relevance 0
Capsaicin also inhibited the interleukin-6-induced STAT3 activation.
Positive_regulation (activation) of STAT3
10) Confidence 0.65 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17505005 Disease Relevance 0.08 Pain Relevance 0
RESULTS: We found that capsaicin inhibited constitutive activation of STAT3 in multiple myeloma cells in a dose- and time-dependent manner, with minimum effect on STAT5.
Positive_regulation (activation) of STAT3
11) Confidence 0.65 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17505005 Disease Relevance 0.08 Pain Relevance 0
Therefore, our studies in PO feline myocardium cannot rule out JAK2's contribution to STAT3 phosphorylation in the early period of PO,41 where it might be subsequently inactivated by the expression of SOCS, and under these conditions, other NTKs might sustain STAT3 activation.
Spec (might) Positive_regulation (activation) of STAT3 in myocardium
12) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.04
An earlier study40 in a murine transverse aortic constriction PO model demonstrates that STAT3 undergoes biphasic acute (3 h) and hypertrophic responses (48 h) via the gp130-mediated JAK2 signaling where the activated STAT3 plays an autoregulatory negative feedback role by promoting the expression of a JAK2 inhibitor protein, SOCS3 (suppressor of cytokine signaling-3).
Positive_regulation (activated) of STAT3 associated with cytokine
13) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.05
PO also caused increased levels of phosphorylated STAT3 in both cytoplasmic and nuclear fractions.
Positive_regulation (increased) of STAT3
14) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC2443357 Disease Relevance 0.49 Pain Relevance 0
Overall, experiments shown in Figure 1 indicate that in PO myocardium STAT3 and P-STAT3 levels are increased in the cytoplasmic and nuclear fractions, that P-STAT3 is recruited to the Triton X-100 insoluble pellet fractions and that this observation could be mimicked in adult cardiomyocytes via integrin stimulation with RGD.


Positive_regulation (increased) of STAT3 in cardiomyocytes
15) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
Our studies demonstrate that STAT3 levels are significantly increased and redistributed to the MSK fraction in 48 h PO myocardium.
Positive_regulation (increased) of STAT3 in myocardium
16) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.27 Pain Relevance 0
Although STAT3 activation has been reported via signaling through Janus Kinase 2 (JAK2) in several cardiac models of hypertrophy, the importance of other nonreceptor tyrosine kinases (NTKs) has not been explored.
Positive_regulation (activation) of STAT3 associated with hypertrophy
17) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC2443357 Disease Relevance 0.37 Pain Relevance 0
Indeed, it appears that STAT3 activation by non-JAK NTKs, such as v-Src, is not susceptible to SOCS overexpression.36
Spec (appears) Positive_regulation (activation) of STAT3
18) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.04
We next determined whether STAT3 activation specifically occurs upon integrin activation.
Spec (whether) Positive_regulation (activation) of STAT3
19) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
Moreover, there is evidence that activated STAT3 provides cardioprotection from ischemic reperfusion injury in vivo.16 Therefore, studies on the activation of STAT3 in the stressed heart are important for understanding its crucial role to the normal functioning of the heart.
Positive_regulation (activated) of STAT3 in heart associated with reperfusion injury
20) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.68 Pain Relevance 0.05

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