INT65676

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Context Info
Confidence 0.23
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.68
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) signal transduction (CGA) small molecule metabolic process (CGA)
extracellular region (CGA) endoplasmic reticulum (PLOD1) cellular nitrogen compound metabolic process (CGA)
CGA (Homo sapiens)
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 49 72.16 Quite High
agonist 48 71.72 Quite High
Potency 1 42.56 Quite Low
algil 1 25.00 Low Low
Versed 1 25.00 Low Low
Opioid 1 25.00 Low Low
corticosteroid 8 5.00 Very Low Very Low Very Low
endometriosis 7 5.00 Very Low Very Low Very Low
dexamethasone 5 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 8 97.84 Very High Very High Very High
Polycystic Ovary Syndrome 21 96.88 Very High Very High Very High
Hyperandrogenism 1 93.96 High High
Endometriosis (extended) 19 93.36 High High
Anovulation 8 89.36 High High
Empty Sella Syndrome 1 72.76 Quite High
Reprotox - General 2 9 71.72 Quite High
Loss Of Sense Of Smell 1 70.32 Quite High
Reprotox - General 1 7 69.96 Quite High
Syndrome 2 69.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It had been estimated that 90% of women in women in WHO type II anovulation would be expected to have polycystic ovarian syndrome (PCOS).119 According to the Rotterdam consensus criteria, PCOS should be considered when two of three features are diagnosed; ovarian dysfunction, features of hyperandrogenism (clinical or biochemical) and PCO morphology.120 Although serum LH is not included as a diagnostic feature, the large majority of women with PCOS would have excess elevated LH concentrations when measured at the appropriate time.121 This may justify the potential advantages in preparations devoid of LH activity as follitropin alpha.
follitropin alpha Binding (activity) of LH associated with polycystic ovary syndrome, hyperandrogenism and anovulation
1) Confidence 0.23 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 1.29 Pain Relevance 0
LH then can be excluded from the eluate by binding to the hCG antibodies (LH immunoaffinity column).
hCG Binding (binding) of LH
2) Confidence 0.05 Published 1996 Journal Drugs Section Abstract Doc Link 8875126 Disease Relevance 0.24 Pain Relevance 0.10
Ovulation induction by hCG is not physiological; the absence of an FSH surge, and the long duration of LH activity associated with hCG action, would contribute to some of the luteal phase abnormalities [196].
hCG Binding (associated) of LH associated with congenital anomalies
3) Confidence 0.00 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.15 Pain Relevance 0

General Comments

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