INT65684

Context Info Confidence 0.62 First Reported 1996 Last Reported 2010 Negated 1 Speculated 4 Reported most in Body Documents 30 Total Number 33 Disease Relevance 24.94 Pain Relevance 1.55

nucleoplasm (MDM2) intracellular (MDM2) enzyme binding (MDM2) protein complex assembly (MDM2) protein complex (MDM2) ligase activity (MDM2)

Anatomy Link Frequency neck 1 eukaryotic cell 1 plaques 1 cleavage 1 head 1 MDM2 (Homo sapiens)

Pain Link Frequency Relevance Heat Dismenorea 18 99.44 Inflammation 86 97.94 palliative 5 95.20 agonist 66 88.08 Chronic pancreatitis 6 83.76 imagery 8 81.04 cva 2 75.16 Migraine 2 71.64 Arthritis 4 68.72 Glutamate 24 52.88

Disease Link Frequency Relevance Heat Endometriosis 36 100.00 Giant Cell Granuloma 14 99.84 Mucinous Adenocarcinoma 4 99.84 Melanoma 182 99.52 Malignant Neoplastic Disease 78 99.48 Giant Cell Tumors 36 99.48 Pancreatic Cancer 22 99.48 Cancer 760 99.16 Leiomyosarcoma 9 98.72 Osteogenic Sarcomas 123 97.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MDM2 expression was significantly higher in the proliferative than in the secretory phase of the cycle.

Gene_expression (expression) of MDM2

1) Confidence 0.62 Published 2005 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 15866118 Disease Relevance 0.16 Pain Relevance 0

CONCLUSION: The expression of p53, MDM2, and p21Waf1 suggests a role for these oncoproteins in the regulation of endometrioma cell growth, but not in adenomyosis.

Gene_expression (expression) of MDM2

2) Confidence 0.62 Published 2005 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 15866118 Disease Relevance 0.14 Pain Relevance 0

The purpose of this study was to examine the distribution of p53, MDM2, and p21Waf1 oncoprotein expression in endometriomas and in adenomyosis.

Gene_expression (expression) of MDM2 associated with endometriosis and dismenorea

3) Confidence 0.62 Published 2005 Journal J. Soc. Gynecol. Investig. Section Abstract Doc Link 15866118 Disease Relevance 0.35 Pain Relevance 0.17

Expression of p53, MDM2, and p21Waf1 oncoproteins was assessed by immunohistochemical nuclear staining.

Gene_expression (Expression) of MDM2

4) Confidence 0.62 Published 2005 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 15866118 Disease Relevance 0.19 Pain Relevance 0

RESULTS: p53, MDM2, and p21Waf1 expression were detected in 20%, 60%, and 80% of endometrioma tissue samples, respectively.

Gene_expression (expression) of MDM2

5) Confidence 0.62 Published 2005 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 15866118 Disease Relevance 0.18 Pain Relevance 0

Immunohistochemical expression of p53, MDM2, and p21Waf1 oncoproteins in endometriomas but not adenomyosis.

Gene_expression (expression) of MDM2 associated with endometriosis and dismenorea

6) Confidence 0.62 Published 2005 Journal J. Soc. Gynecol. Investig. Section Title Doc Link 15866118 Disease Relevance 0.20 Pain Relevance 0.19

In this context, it is worth noting the importance of molecular analysis (amplification and/or ovexpression of MDM2 and CDK4) to help diagnosis in ambiguous cases.

Gene_expression (ovexpression) of MDM2

7) Confidence 0.60 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2995804 Disease Relevance 0.83 Pain Relevance 0

METHODS AND RESULTS: We analyzed the expression of apoptotic genes such as BAX, CASP1, FAS, FAS L, FOS, MDM2, NFkB2, P53, PCNA, TERT, and XRCC1 in coronary plaques collected with directional coronary atherectomy from 15 patients with stable angina and 15 with acute coronary syndromes without ST elevation (ACS).

Spec (analyzed) Gene_expression (expression) of MDM2 in plaques

8) Confidence 0.59 Published 2004 Journal Circulation Section Body Doc Link 15364800 Disease Relevance 0.19 Pain Relevance 0

High HDM2 expression was shown to inhibit p53 and its function of eliminating abnormal cells [105, 106].

Gene_expression (expression) of HDM2

9) Confidence 0.55 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902045 Disease Relevance 0.88 Pain Relevance 0

High expression of the HDM2-gene on 12q15 is found in 97% of UM [69].

Gene_expression (expression) of HDM2-gene associated with melanoma

10) Confidence 0.55 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902045 Disease Relevance 0.83 Pain Relevance 0

RESULTS: p53, MDM2, and p21Waf1 expression were detected in 20%, 60%, and 80% of endometrioma tissue samples, respectively.

Gene_expression (detected) of MDM2

11) Confidence 0.54 Published 2005 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 15866118 Disease Relevance 0.18 Pain Relevance 0

The purpose of this study was to examine the distribution of p53, MDM2, and p21Waf1 oncoprotein expression in endometriomas and in adenomyosis.

Spec (examine) Gene_expression (distribution) of MDM2 associated with endometriosis and dismenorea

12) Confidence 0.54 Published 2005 Journal J. Soc. Gynecol. Investig. Section Abstract Doc Link 15866118 Disease Relevance 0.35 Pain Relevance 0.17

There are a variety of genetic changes and mutations inclusive of TP53 and MDM2 expression associated with progression of leiomyosarcomas [41].

Gene_expression (expression) of MDM2 associated with leiomyosarcoma

13) Confidence 0.54 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.41 Pain Relevance 0

EMA, Bcl-2, Ki67, PCNA, Bad, Mcl-1; bcl-x, bak, mdm2, bax, p16, p21, p27, p53 and Cyclin D1 expression were evaluated by the standard avidin-biotin complex method with positive and negative controls as per standard laboratory protocol.

Gene_expression (expression) of mdm2

14) Confidence 0.53 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.75 Pain Relevance 0

Another study analyzed the clinicopathological features and immunohistochemical expression of p53, MDM2, CDK4, PCNA and Ki67 proteins in 25 head and neck OS and found 52% positivity for p53, 24% for MDM2, 84% for CDK4, 92% for PCNA and 88% for Ki-67 suggesting PCNA as one of most favourable prognostic marker [21] .

Spec (analyzed) Gene_expression (expression) of MDM2 in head associated with osteogenic sarcomas

15) Confidence 0.52 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC3020523 Disease Relevance 1.23 Pain Relevance 0

In contrast, all 31 adenomyosis tissue samples were negative for p53, MDM2, and p21Waf1 expression.

Gene_expression (expression) of MDM2

16) Confidence 0.48 Published 2005 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 15866118 Disease Relevance 0.15 Pain Relevance 0

Although p53 mutations have been extensively studied in human breast cancer, only a few studies have been conducted on the prognostic values of the upstream regulators for p53, such as overexpression of Hdm2, TBX2/3, Pokemon, or inactivation of p14ARF, hDMP1.

Gene_expression (overexpression) of Hdm2 associated with breast cancer

17) Confidence 0.48 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.95 Pain Relevance 0.03

Disruption of p53-murine double minute-2 (MDM2) complex formation resulted in increasing the expression of MDM2 60-kDa cleavage fragment.

Gene_expression (expression) of MDM2 in cleavage

18) Confidence 0.45 Published 2003 Journal Eur. J. Clin. Invest. Section Body Doc Link 14511359 Disease Relevance 0.12 Pain Relevance 0

In our study, all cases demonstrated diffuse expression of Bax, Bad and Bak proteins in contrast to weak or negative expression of Mcl-1, MDM2 and Bcl-x.

Gene_expression (expression) of MDM2

19) Confidence 0.41 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 1.06 Pain Relevance 0

Immunohistochemical expression of Bad, Mcl-1, bcl-x, bak, mdm2, bax, p16, p21, p53, p27, EMA, Bcl-2, Ki67 and PCNA was correlated with clinico-pathological data including survival outcomes.

Gene_expression (expression) of mdm2

20) Confidence 0.41 Published 2010 Journal World J Surg Oncol Section Abstract Doc Link PMC2913917 Disease Relevance 0.86 Pain Relevance 0

General Comments

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