INT65697

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Context Info
Confidence 0.69
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 12.52
Pain Relevance 13.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN3B)
Anatomy Link Frequency
brain 4
neuronal 2
neurons 1
masseter 1
synapses 1
GRIN3B (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 279 100.00 Very High Very High Very High
long-term potentiation 155 100.00 Very High Very High Very High
Glutamate 314 99.90 Very High Very High Very High
Anterior cingulate cortex 109 99.88 Very High Very High Very High
substance P 14 99.82 Very High Very High Very High
Dorsal horn neuron 28 99.48 Very High Very High Very High
gABA 194 99.28 Very High Very High Very High
nMDA receptor antagonist 15 99.24 Very High Very High Very High
addiction 7 98.90 Very High Very High Very High
Central nervous system 25 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 51 99.10 Very High Very High Very High
Schizophrenia 38 99.08 Very High Very High Very High
Anxiety Disorder 570 98.96 Very High Very High Very High
Toxicity 27 98.94 Very High Very High Very High
Post-traumatic Stress Disorder 528 98.04 Very High Very High Very High
Cognitive Disorder 96 97.64 Very High Very High Very High
Pain 164 97.36 Very High Very High Very High
Drug Induced Neurotoxicity 31 96.96 Very High Very High Very High
Apoptosis 33 96.92 Very High Very High Very High
Stress 600 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sustained activation of these receptors, and especially of the NMDA receptor, is a casuistic phenomenon that leads to the neuronal death underlying neurodegeneration.
Positive_regulation (activation) of NMDA receptor in neuronal associated with nmda receptor and death
1) Confidence 0.69 Published 2006 Journal Curr. Pharm. Des. Section Abstract Doc Link 17073661 Disease Relevance 0.59 Pain Relevance 0.54
Finally, NMDA receptor activation would appear to be responsible for the generation of nitric oxide and prostanoids which further enhance pain transmission whereas adenosine release acts to control these NMDA mediated events.
Positive_regulation (activation) of NMDA receptor associated with pain, adenocard and nmda receptor
2) Confidence 0.47 Published 1997 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 9061093 Disease Relevance 0.61 Pain Relevance 1.30
The mechanism seems to be allosteric activation of the NMDA receptor.


Positive_regulation (activation) of NMDA receptor
3) Confidence 0.18 Published 2004 Journal Anesthesiology Section Body Doc Link 15166575 Disease Relevance 0 Pain Relevance 0
We conclude that NMDA receptor activation is not solely responsible for the neuronal pathology resulting as a consequence of epileptiform discharge.
Positive_regulation (activation) of NMDA receptor in neuronal associated with nmda receptor
4) Confidence 0.16 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8876450 Disease Relevance 0.24 Pain Relevance 0.51
One potential explanation for this beneficial effect is the inhibition of NMDA receptor activation.
Positive_regulation (activation) of NMDA receptor associated with nmda receptor
5) Confidence 0.13 Published 2006 Journal Br J Anaesth Section Abstract Doc Link 16299047 Disease Relevance 0.28 Pain Relevance 0.36
These findings indicate that human NGF-induced sensitization of masseter nociceptors results, in part, from the activation of TrkA receptors, but does not appear to be mediated through enhanced peripheral NMDA receptor activity.
Positive_regulation (enhanced) of NMDA receptor in masseter associated with nerve growth factor, nmda receptor and nociceptor
6) Confidence 0.08 Published 2010 Journal Pain Section Abstract Doc Link 20064691 Disease Relevance 0.12 Pain Relevance 0.98
A majority of synapses that experience LTP involve an increase in calcium which is mediated through activation of the NMDA receptor.
Positive_regulation (activation) of NMDA receptor in synapses associated with nmda receptor and long-term potentiation
7) Confidence 0.06 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0.38
Soluble guanylate cyclase represents the most important NO receptor in the brain (Dawson VL and Dawson TM 1995), with its activation by NO following glutamate-mediated activation of the NMDA receptor leading to an increase in the second messenger – cyclic guanosine monophosphate (cGMP) (Fedele et al 2001).
Positive_regulation (activation) of NMDA receptor in brain associated with glutamate and nmda receptor
8) Confidence 0.06 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0 Pain Relevance 0.22
The primary neural substrate of kindling involves glutamate and NMDA receptor activation, with inhibitory GABA pathways exerting essentially a permissive role on the kindling action of glutamate (Post and Weiss 1998).
Positive_regulation (activation) of NMDA receptor in neural associated with gaba, glutamate and nmda receptor
9) Confidence 0.06 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.87 Pain Relevance 0.39
Despite the indication that overstimulation of the NMDA receptor might explain the neurodegeneration observed in PTSD, preclinical studies have found that inhibition of glutamate reuptake, resulting in increased glutamate levels, leads to a decrease in NMDA receptor density (Cebers et al 1999).
Positive_regulation (overstimulation) of NMDA receptor associated with glutamate, post-traumatic stress disorder and nmda receptor
10) Confidence 0.04 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.97 Pain Relevance 0.58
The NMDA receptor is involved in the normal processes of memory encoding while overstimulation of the NMDA receptor leads to the formation of strongly ingrained emotional memories via excessive mobilization of free cytosolic Ca2+.
Positive_regulation (overstimulation) of NMDA receptor associated with nmda receptor
11) Confidence 0.04 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.69 Pain Relevance 0.33
Furthermore, increasing NMDA receptor function by co-administration of glycine, D-serine, or D-alanine with atypical antipsychotics improved positive, negative, and cognitive symptoms, in schizophrenia patients when compared to antipsychotic treatment alone [29-32].
Positive_regulation (increasing) of NMDA receptor associated with cognitive disorder, nmda receptor and schizophrenia
12) Confidence 0.04 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC2905773 Disease Relevance 1.20 Pain Relevance 0.44
In addition, acute release of NO via nNOS and NMDA receptor activation down-regulates the NMDA receptor, while localized release of 5HT will attenuate the mobilization of Ca2+, NO, and cGMP (Marcoli et al 1997; Maura et al 2000).
Positive_regulation (activation) of NMDA receptor associated with nmda receptor and 5ht
13) Confidence 0.04 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.81 Pain Relevance 0.49
Soluble guanylate cyclase represents the most important NO receptor in the brain (Dawson VL and Dawson TM 1995), with its activation by NO following glutamate-mediated activation of the NMDA receptor leading to an increase in the second messenger – cyclic guanosine monophosphate (cGMP) (Fedele et al 2001).
Neg (NO) Positive_regulation (leading) of NMDA receptor in brain associated with glutamate and nmda receptor
14) Confidence 0.04 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0 Pain Relevance 0.22
However, in other areas of the brain, there is no requirement of SP for the induction of NMDA receptor dependent LTP [39].
Positive_regulation (induction) of NMDA receptor in brain associated with nmda receptor, long-term potentiation and substance p
15) Confidence 0.02 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0.36 Pain Relevance 1.19
In the ACC, the induction of LTP by different protocols is mostly NMDA receptor dependent.
Positive_regulation (induction) of NMDA receptor associated with nmda receptor, long-term potentiation and anterior cingulate cortex
16) Confidence 0.02 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0.37 Pain Relevance 1.18
Thus, there is excessive NMDA receptor activation.
Positive_regulation (activation) of NMDA receptor associated with nmda receptor
17) Confidence 0.01 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386351 Disease Relevance 1.17 Pain Relevance 1.65
enhances NMDA receptor-mediated Ca2+ responses via activating tyrosine protein kinase Src [94], which is known to enhance NMDA receptor activity in dorsal horn neurons [52, 95].
Positive_regulation (enhance) of NMDA receptor in neurons associated with nmda receptor and dorsal horn neuron
18) Confidence 0.01 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096535 Disease Relevance 0.56 Pain Relevance 0.80
Although several mechanisms are proposed, upregulation of the NR1 subunit of the NMDA receptor appears to be an important first step in the pathway to anesthetic-induced neurotoxicity.
Positive_regulation (upregulation) of NMDA receptor associated with drug induced neurotoxicity and nmda receptor
19) Confidence 0.01 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.62 Pain Relevance 0.24
Thus, continuous exposure of developing brains to ketamine causes selective cell death by a mechanism that involves a compensatory upregulation of NMDA receptor subunits (Wang et al., 2005, 2006).
Positive_regulation (upregulation) of NMDA receptor in brains associated with ketamine, nmda receptor and death
20) Confidence 0.01 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.66 Pain Relevance 0.46

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