INT65698

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Context Info
Confidence 0.81
First Reported 1996
Last Reported 2011
Negated 2
Speculated 2
Reported most in Abstract
Documents 118
Total Number 123
Disease Relevance 77.54
Pain Relevance 32.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL2) extracellular space (CCL2) aging (CCL2)
extracellular region (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)
Anatomy Link Frequency
monocyte 24
endothelial cells 11
macrophages 6
fibroblasts 4
platelets 3
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1424 100.00 Very High Very High Very High
cytokine 1016 100.00 Very High Very High Very High
chemokine 629 100.00 Very High Very High Very High
agonist 167 99.82 Very High Very High Very High
Codeine 8 99.80 Very High Very High Very High
Morphine 126 99.70 Very High Very High Very High
ischemia 62 99.58 Very High Very High Very High
Sciatic nerve 1 99.48 Very High Very High Very High
metalloproteinase 357 99.44 Very High Very High Very High
opiate 56 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1628 100.00 Very High Very High Very High
Coronary Artery Disease 433 100.00 Very High Very High Very High
Adhesions 348 100.00 Very High Very High Very High
Lymphatic System Cancer 106 99.96 Very High Very High Very High
Infection 510 99.90 Very High Very High Very High
Primary Sclerosing Cholangitis 298 99.84 Very High Very High Very High
Glioma 50 99.84 Very High Very High Very High
Choroideremia 1494 99.80 Very High Very High Very High
Cv Unclassified Under Development 92 99.58 Very High Very High Very High
Cancer 523 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we examined the effect of lidocaine on lipopolysaccharide-stimulated MCP-1 secretion and MCP-1 induced chemotaxis in a human monocytic cell line, THP-1.
Localization (secretion) of MCP-1 in THP-1 associated with lidocaine
1) Confidence 0.81 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14570645 Disease Relevance 0.39 Pain Relevance 0.67
In addition, the reported higher fetal MCP-1 concentrations compared to respective maternal ones may be attributed to the fact that, in late gestation, MCP-1 is predominantly released by embryonically derived tissues, including the chorion and the placenta [4].
Localization (released) of MCP-1 in placenta
2) Confidence 0.75 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.13 Pain Relevance 0
Recent evidence from mouse models suggests targeting MCP-1 or complement may emerge as viable new treatment options for viral arthritides.
Localization (targeting) of MCP-1 associated with infectious arthritis
3) Confidence 0.74 Published 2009 Journal Pharmacol. Ther. Section Abstract Doc Link 19788897 Disease Relevance 1.17 Pain Relevance 0.19
Forskolin, a direct stimulator of adenylyl cyclase, decreased the interleukin (IL)-1beta-induced eotaxin and MCP-1 release by 73+/-8 and 65+/-6%, respectively. 8Bromo-cAMP, a cAMP analogue, similarly decreased the chemokine production by 58+/-9 and 63+/-8% for eotaxin and MCP-1, respectively.
Localization (release) of MCP-1 associated with chemokine
4) Confidence 0.73 Published 2003 Journal Eur. Respir. J. Section Abstract Doc Link 12952251 Disease Relevance 0.23 Pain Relevance 0.21
H-89, an inhibitor of PKA, was able to inhibit the decrease in eotaxin and MCP-1 protein release induced by forskolin.
Localization (release) of MCP-1
5) Confidence 0.73 Published 2003 Journal Eur. Respir. J. Section Abstract Doc Link 12952251 Disease Relevance 0.17 Pain Relevance 0.23
In this study, we examined the effect of lidocaine on lipopolysaccharide-stimulated MCP-1 secretion and MCP-1 induced chemotaxis in a human monocytic cell line, THP-1.
Localization (secretion) of MCP-1 in THP-1 associated with lidocaine
6) Confidence 0.71 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14570645 Disease Relevance 0.39 Pain Relevance 0.67
CCL2 was also shown to be released from remote neurons in a rat nerve injury model [11], from murine neurons in a compression model [12], and from murine neurons in an ischemia model [13].
Localization (released) of CCL2 in neurons associated with nervous system injury and ischemia
7) Confidence 0.71 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0.56 Pain Relevance 0.62
RESULTS: Results show that the monocyte chemoattractant protein-1 in expressed prostatic secretions is nonfunctional with an inability to mediate human monocyte chemotaxis, or mediate signaling in monocytes or prostate epithelial cells.
Localization (secretions) of monocyte chemoattractant protein-1 in monocytes
8) Confidence 0.71 Published 2010 Journal J. Urol. Section Body Doc Link 20723928 Disease Relevance 0.08 Pain Relevance 0
Other investigators have shown that the combination of HIV-1 Tat protein and morphine increased the release of CCL2 from astrocytes [25] and subsequently promoted the chemotaxis of microglia [20].
Localization (release) of CCL2 in microglia associated with acquired immune deficiency syndrome or hiv infection and morphine
9) Confidence 0.70 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0.10 Pain Relevance 1.12
The release of monocyte chemoattractant protein-1 (MCP-1, also known as CCL2), in particular, is potentiated by opiate-HIV Tat interactions in vitro.
Localization (release) of monocyte chemoattractant protein-1 in monocyte associated with acquired immune deficiency syndrome or hiv infection and opiate
10) Confidence 0.70 Published 2006 Journal Glia Section Abstract Doc Link 16206161 Disease Relevance 0.70 Pain Relevance 0.66
The release of monocyte chemoattractant protein-1 (MCP-1, also known as CCL2), in particular, is potentiated by opiate-HIV Tat interactions in vitro.
Localization (release) of MCP-1 in monocyte associated with acquired immune deficiency syndrome or hiv infection and opiate
11) Confidence 0.70 Published 2006 Journal Glia Section Abstract Doc Link 16206161 Disease Relevance 0.70 Pain Relevance 0.66
In addition, the reported higher fetal MCP-1 concentrations compared to respective maternal ones may be attributed to the fact that, in late gestation, MCP-1 is predominantly released by embryonically derived tissues, including the chorion and the placenta [4].
Localization (released) of MCP-1 in placenta
12) Confidence 0.70 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.12 Pain Relevance 0
Homocysteine induced the expression and secretion of the pro-atherogenic chemokine, monocyte chemoattractant protein-1 (MCP-1), and the cytokine, interleukin-8 (IL-8), in human aortic endothelial cells [7].
Localization (secretion) of monocyte chemoattractant protein-1 in endothelial cells associated with chemokine and cytokine
13) Confidence 0.68 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0.59 Pain Relevance 0.16
In the present study we report the expression pattern of the chemokines interferon-gamma-inducible protein (IP)-10, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and regulated upon activation normal T cell expressed and secreted (RANTES) in sciatic nerves from animals with myelin-induced experimental autoimmune neuritis, using a semiquantitative reverse transcriptase-PCR dot-blot hybridization assay.
Localization (secreted) of monocyte chemoattractant protein in sciatic nerves associated with chemokine, inflammation, experimental autoimmune neuritis, sciatic nerve and neuritis
14) Confidence 0.68 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 11024541 Disease Relevance 0.76 Pain Relevance 0.61
Since VEGF was significantly increased in PDR and CRVO patients (Figure 1), the correlation between VEGF and the three factors: IL-6, IL-8, and MCP-1 in PDR and CRVO were investigated.
Spec (investigated) Localization (correlation) of MCP-1
15) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780733 Disease Relevance 0.18 Pain Relevance 0
The results showed that (i) aspirin, fenofibrate and clofibrate decrease significantly the MCP-1 expression and secretion in human endothelial cells; (ii) the high glucose up-regulated expression of MCP-1 in endothelial cells was significantly reduced by inhibitors of NF-kB and reactive oxygen species; (iii) all drugs notably decrease the level of the reactive oxygen species and activation of NF-kB and AP-1.
Localization (secretion) of MCP-1 in endothelial cells associated with aspirin
16) Confidence 0.68 Published 2006 Journal Vascul. Pharmacol. Section Abstract Doc Link 16600694 Disease Relevance 0.40 Pain Relevance 0.34
In this study, we show that human cere-bromicrovascular endothelial cells (HCEC) subjected to a 4 h in vitro ischemia (hypoxia + glucose deprivation) followed by a 4-24 h recovery express elevated levels of ICAM-1, IL-8, and MCP-1 mRNAs (semi-quantitative RT-PCR) and secrete increased amounts of the immunoreactive chemokines IL-8 and MCP-1 (ELISA).
Localization (secrete) of MCP-1 in HCEC associated with chemokine, hypoxia and ischemia
17) Confidence 0.66 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 1.11 Pain Relevance 0.48
The immunosuppressant cyclosporin A (50 microM) partially reduced the ischemia-stimulated IL-8 and MCP-1 secretion by HCEC.
Localization (secretion) of MCP-1 in HCEC associated with ischemia
18) Confidence 0.66 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 1.13 Pain Relevance 0.60
resp.) while fetal MCP-1 concentrations were significantly lower
Localization (concentrations) of MCP-1
19) Confidence 0.65 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.08 Pain Relevance 0.14
resp.) while fetal MCP-1 concentrations were significantly lower
Localization (concentrations) of MCP-1
20) Confidence 0.65 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.06 Pain Relevance 0.06

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