INT65699

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.56
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCL3) extracellular space (CCL3) extracellular region (CCL3)
intracellular (CCL3) cytoskeleton organization (CCL3) kinase activity (CCL3)
Anatomy Link Frequency
Macrophage 3
skin 1
basophils 1
microglia 1
mast cells 1
CCL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 46 100.00 Very High Very High Very High
chemokine 28 100.00 Very High Very High Very High
Codeine 8 99.80 Very High Very High Very High
Inflammatory mediators 7 94.28 High High
Pain 2 84.76 Quite High
imagery 1 66.96 Quite High
Inflammatory response 3 49.52 Quite Low
Central nervous system 15 25.00 Low Low
cytokine 17 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 57 100.00 Very High Very High Very High
Apoptosis 56 93.04 High High
Lyme Disease 13 91.24 High High
Neuroblastoma 5 90.08 High High
Lyme Neuroborreliosis 5 88.64 High High
Disease 5 86.68 High High
Pain 2 84.76 Quite High
Osteolysis 2 81.28 Quite High
Multiple Myeloma 4 79.16 Quite High
Neurodegenerative Disease 10 71.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Macrophage inflammatory protein-1 alpha (MIP-1a) is a member of the chemokine family, and was originally determined as a soluble factor secreted from activated macrophages.
Localization (secreted) of MIP-1a in Macrophage associated with chemokine and inflammation
1) Confidence 0.78 Published 2005 Journal Leuk. Lymphoma Section Abstract Doc Link 16019547 Disease Relevance 0.57 Pain Relevance 0.22
Macrophage inflammatory protein-1 alpha (MIP-1a) is a member of the chemokine family, and was originally determined as a soluble factor secreted from activated macrophages.
Localization (secreted) of Macrophage inflammatory protein-1 alpha in Macrophage associated with chemokine and inflammation
2) Confidence 0.73 Published 2005 Journal Leuk. Lymphoma Section Abstract Doc Link 16019547 Disease Relevance 0.58 Pain Relevance 0.22
Histamine release in intact human skin by monocyte chemoattractant factor-1, RANTES, macrophage inflammatory protein-1 alpha, stem cell factor, anti-IgE, and codeine as determined by an ex vivo skin microdialysis technique.
Localization (release) of macrophage inflammatory protein-1 alpha in skin associated with inflammation and codeine
3) Confidence 0.56 Published 1996 Journal J. Allergy Clin. Immunol. Section Title Doc Link 8876555 Disease Relevance 0.10 Pain Relevance 0.39
Monocyte chemoattractant factor-1, RANTES, and macrophage inflammatory protein-1 alpha in concentrations of 10(-10) to 10(-6) mol/L did not release histamine; histamine release by 10(-6) mol/L chemokine was less than 0.2 pmol/20 min.
Neg (not) Localization (release) of macrophage inflammatory protein-1 alpha in macrophage
4) Confidence 0.56 Published 1996 Journal J. Allergy Clin. Immunol. Section Body Doc Link 8876555 Disease Relevance 0.05 Pain Relevance 0
CONCLUSION: We conclude that the chemokines monocyte chemoattractant factor-1, RANTES, and macrophage inflammatory protein-1 alpha do not release histamine from human skin mast cells.


Neg (not) Localization (release) of macrophage inflammatory protein-1 alpha in mast cells
5) Confidence 0.56 Published 1996 Journal J. Allergy Clin. Immunol. Section Body Doc Link 8876555 Disease Relevance 0 Pain Relevance 0
BACKGROUND: The chemokines monocyte chemoattractant factor-1, RANTES, and macrophage inflammatory protein-1 alpha release histamine from human basophils, as well as rat and mouse mast cells.
Localization (release) of macrophage inflammatory protein-1 alpha in basophils associated with chemokine and inflammation
6) Confidence 0.56 Published 1996 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 8876555 Disease Relevance 0.17 Pain Relevance 0.26
In experiments where B. burgdorferi was co-cultured in vitro with primary microglia, we observed robust expression and release of IL-6 and IL-8, CCL2 (MCP-1), CCL3 (MIP-1?)
Localization (release) of CCL3 in microglia
7) Confidence 0.20 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2771360 Disease Relevance 1.08 Pain Relevance 0.16

General Comments

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