INT65700

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 1996
Last Reported 2007
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 4.00
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CCR1) plasma membrane (CCR1) cell-cell signaling (CCR1)
signal transducer activity (CCR1)
Anatomy Link Frequency
monocyte 4
macrophage 1
skin 1
basophils 1
mast cells 1
CCR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 255 100.00 Very High Very High Very High
chemokine 79 100.00 Very High Very High Very High
Codeine 8 99.80 Very High Very High Very High
dexamethasone 7 98.98 Very High Very High Very High
cytokine 175 98.80 Very High Very High Very High
Arthritis 90 98.48 Very High Very High Very High
rheumatoid arthritis 261 97.36 Very High Very High Very High
aspirin 5 75.00 Quite High
Inflammatory stimuli 5 72.48 Quite High
cINOD 7 71.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 281 100.00 Very High Very High Very High
Arthritis 69 98.48 Very High Very High Very High
Rheumatoid Arthritis 261 97.36 Very High Very High Very High
Apoptosis 29 89.52 High High
Asthma 41 81.00 Quite High
Hypersensitivity 3 80.60 Quite High
Experimental Arthritis 39 80.28 Quite High
Disease 65 78.48 Quite High
Injury 3 50.48 Quite High
Hematological Disease 1 32.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of the cells with dexamethasone inhibited expression of RANTES mRNA and inhibited secretion of RANTES protein.
Localization (secretion) of RANTES protein associated with dexamethasone
1) Confidence 0.51 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.35 Pain Relevance 0.23
express only select types of the numerous chemokine receptors (for example, CCR1, 2, 5, 7, and 8 as well as CX3CR1), representing a partially specific basis for prominent trafficking of monocyte/M?
Localization (example) of CCR1 in monocyte associated with chemokine
2) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.89 Pain Relevance 0.81
express only select types of the numerous chemokine receptors (for example, CCR1, 2, 5, 7, and 8 as well as CX3CR1), representing a partially specific basis for prominent trafficking of monocyte/M?
Localization (trafficking) of CCR1 in monocyte associated with chemokine
3) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 1.02 Pain Relevance 0.89
express only select types of the numerous chemokine receptors (for example, CCR1, 2, 5, 7, and 8 as well as CX3CR1), representing a partially specific basis for prominent trafficking of monocyte/M?
Localization (well) of CCR1 in monocyte associated with chemokine
4) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.90 Pain Relevance 0.81
CONCLUSION: We conclude that the chemokines monocyte chemoattractant factor-1, RANTES, and macrophage inflammatory protein-1 alpha do not release histamine from human skin mast cells.


Neg (not) Localization (release) of RANTES in mast cells
5) Confidence 0.18 Published 1996 Journal J. Allergy Clin. Immunol. Section Body Doc Link 8876555 Disease Relevance 0 Pain Relevance 0
Monocyte chemoattractant factor-1, RANTES, and macrophage inflammatory protein-1 alpha in concentrations of 10(-10) to 10(-6) mol/L did not release histamine; histamine release by 10(-6) mol/L chemokine was less than 0.2 pmol/20 min.
Neg (not) Localization (release) of RANTES in macrophage
6) Confidence 0.18 Published 1996 Journal J. Allergy Clin. Immunol. Section Body Doc Link 8876555 Disease Relevance 0.05 Pain Relevance 0
Histamine release in intact human skin by monocyte chemoattractant factor-1, RANTES, macrophage inflammatory protein-1 alpha, stem cell factor, anti-IgE, and codeine as determined by an ex vivo skin microdialysis technique.
Localization (release) of RANTES in skin associated with inflammation and codeine
7) Confidence 0.18 Published 1996 Journal J. Allergy Clin. Immunol. Section Title Doc Link 8876555 Disease Relevance 0.10 Pain Relevance 0.38
BACKGROUND: The chemokines monocyte chemoattractant factor-1, RANTES, and macrophage inflammatory protein-1 alpha release histamine from human basophils, as well as rat and mouse mast cells.
Localization (release) of RANTES in basophils associated with chemokine and inflammation
8) Confidence 0.17 Published 1996 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 8876555 Disease Relevance 0.17 Pain Relevance 0.26
In parallel experiments involving human colonic mucosa ex vivo, LXA(4)potently attenuated TNF-alpha-stimulated release of the C-X-C chemokine IL-8, and the C-C chemokines monocyte-chemoattractant protein-1 (MCP-1) and RANTES.
Localization (release) of RANTES in monocyte associated with chemokine
9) Confidence 0.11 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11509622 Disease Relevance 0.51 Pain Relevance 0.54

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox