INT65701

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Context Info
Confidence 0.65
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 2.46
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (KITLG) signal transduction (KITLG) extracellular space (KITLG)
extracellular region (KITLG) cell adhesion (KITLG) plasma membrane (KITLG)
Anatomy Link Frequency
bone marrow 1
skin 1
basophils 1
KITLG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 100.00 Very High Very High Very High
Codeine 6 99.80 Very High Very High Very High
chemokine 6 96.56 Very High Very High Very High
interstitial cystitis 6 85.16 High High
Pain 8 54.08 Quite High
headache 1 50.88 Quite High
Infliximab 2 32.80 Quite Low
Adalimumab 1 31.48 Quite Low
rheumatoid arthritis 24 5.00 Very Low Very Low Very Low
Arthritis 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 100.00 Very High Very High Very High
Myeloid Leukemia 4 98.92 Very High Very High Very High
Leukemia 2 98.72 Very High Very High Very High
Cancer 12 98.68 Very High Very High Very High
Necrosis 12 98.44 Very High Very High Very High
Chronic Renal Failure 25 94.68 High High
Overactive Bladder 12 88.08 High High
Interstitial Cystitis 6 85.16 High High
Renal Disease 20 76.52 Quite High
Fibromyalgia 1 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All chemokines, but not SCF, released histamine from human basophils.
Localization (released) of SCF in basophils
1) Confidence 0.65 Published 1996 Journal J. Allergy Clin. Immunol. Section Body Doc Link 8876555 Disease Relevance 0 Pain Relevance 0
Furthermore, IL-1beta and tumor necrosis factor-alpha alone induced significant release of MCP-1, IL-6 and SCF but in combination with IL-4 or IL-13 it induced greater secretion of MCP-1, IL-6 and SCF.
Localization (release) of SCF
2) Confidence 0.63 Published 2006 Journal J. Urol. Section Body Doc Link 16407046 Disease Relevance 0.11 Pain Relevance 0
IL-4 and IL-13 given separately stimulated MCP-1, IL-6 and SCF secretion in a concentration (0.01 to 100 ng/ml) and time (0 to 24 hours) dependent manner.
Localization (secretion) of SCF
3) Confidence 0.63 Published 2006 Journal J. Urol. Section Body Doc Link 16407046 Disease Relevance 0.13 Pain Relevance 0
Protein expression, and the secretion of MCP-1, IL-6 and SCF were assayed by semiquantitative reverse transcriptase-polymerase chain reaction and specific enzyme-linked immunosorbent assay.
Localization (secretion) of SCF
4) Confidence 0.63 Published 2006 Journal J. Urol. Section Body Doc Link 16407046 Disease Relevance 0.19 Pain Relevance 0
Furthermore, IL-1beta and tumor necrosis factor-alpha alone induced significant release of MCP-1, IL-6 and SCF but in combination with IL-4 or IL-13 it induced greater secretion of MCP-1, IL-6 and SCF.
Localization (secretion) of SCF
5) Confidence 0.63 Published 2006 Journal J. Urol. Section Body Doc Link 16407046 Disease Relevance 0.11 Pain Relevance 0
RESULTS: Unstimulated cells released low amounts of MCP-1, IL-6 and SCF.
Localization (released) of SCF
6) Confidence 0.63 Published 2006 Journal J. Urol. Section Body Doc Link 16407046 Disease Relevance 0.17 Pain Relevance 0
We investigated whether HDSMCs are capable of expressing and releasing MCP-1, IL-6 and SCF in response to IL-4, IL-13, IL-1beta and tumor necrosis factor-alpha.
Localization (releasing) of SCF associated with necrosis and cancer
7) Confidence 0.55 Published 2006 Journal J. Urol. Section Abstract Doc Link 16407046 Disease Relevance 0.60 Pain Relevance 0.09
RESULTS: Anti-IgE (4 to 4000 U/ml), codeine (0.001 to 1 mg/ml), and SCF (5.4 x (10(-11) to 10(-8) mol/L)) released histamine in a dose-dependent manner; maximum histamine release was 97.4, 116.3, and 9.5 pmol/20 min, respectively.
Localization (released) of SCF
8) Confidence 0.50 Published 1996 Journal J. Allergy Clin. Immunol. Section Body Doc Link 8876555 Disease Relevance 0.06 Pain Relevance 0
Histamine release in intact human skin by monocyte chemoattractant factor-1, RANTES, macrophage inflammatory protein-1 alpha, stem cell factor, anti-IgE, and codeine as determined by an ex vivo skin microdialysis technique.
Localization (release) of stem cell factor in skin associated with inflammation and codeine
9) Confidence 0.50 Published 1996 Journal J. Allergy Clin. Immunol. Section Title Doc Link 8876555 Disease Relevance 0.10 Pain Relevance 0.39
All of these results support the use of the KDQOL-SF™ with haemodialysis patients in Singapore.
Localization (use) of KDQOL-SF
10) Confidence 0.38 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC3014913 Disease Relevance 0.40 Pain Relevance 0.05
One of the possible mechanisms of action could be related to SCF secretion.
Localization (secretion) of SCF
11) Confidence 0.06 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
0.13, and SF-6D ranged from ?
Localization (ranged) of SF-6D
12) Confidence 0.06 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2761817 Disease Relevance 0 Pain Relevance 0
Autocrine and paracrine secretion of angiogenic and hematopoietic growth factors such as vascular endothelial growth factor (VEGF) and stem cell factor (SCF) in the bone marrow microenvironment may promote proliferation and survival of leukemic blasts.
Localization (secretion) of SCF in bone marrow
13) Confidence 0.03 Published 2003 Journal Blood Section Abstract Doc Link 12843001 Disease Relevance 0.59 Pain Relevance 0.05

General Comments

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