INT65713

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Context Info
Confidence 0.81
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 42
Total Number 43
Disease Relevance 39.55
Pain Relevance 11.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ICAM1) cell adhesion (ICAM1) plasma membrane (ICAM1)
Anatomy Link Frequency
epithelial cells 4
endothelial cell 4
NK cell 3
macrophages 2
plasma 2
ICAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 336 100.00 Very High Very High Very High
Inflammatory response 68 99.92 Very High Very High Very High
qutenza 36 99.76 Very High Very High Very High
Angina 48 99.50 Very High Very High Very High
ischemia 31 99.02 Very High Very High Very High
endometriosis 299 98.80 Very High Very High Very High
Inflammatory stimuli 12 98.76 Very High Very High Very High
Inflammation 794 98.44 Very High Very High Very High
dexamethasone 143 97.84 Very High Very High Very High
metalloproteinase 66 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 932 100.00 Very High Very High Very High
Disease 458 100.00 Very High Very High Very High
Common Cold 2 100.00 Very High Very High Very High
INFLAMMATION 885 99.74 Very High Very High Very High
Cv General 3 Under Development 28 99.50 Very High Very High Very High
Necrosis 42 99.06 Very High Very High Very High
Death 64 99.04 Very High Very High Very High
Coronary Artery Disease 56 99.02 Very High Very High Very High
Endometriosis 378 99.00 Very High Very High Very High
Cancer 153 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, sICAM-1 release is increased, especially in coronary circulation in unstable angina.
Localization (release) of sICAM-1 associated with angina
1) Confidence 0.81 Published 1999 Journal Am. J. Cardiol. Section Abstract Doc Link 10073782 Disease Relevance 0.82 Pain Relevance 0.76
These results suggest an enhanced release of ICAM-1 into plasma in the early stage of acute necrotizing pancreatitis.
Localization (release) of ICAM-1 in plasma associated with acute necrotizing pancreatitis
2) Confidence 0.81 Published 1996 Journal Immunobiology Section Abstract Doc Link 8877397 Disease Relevance 1.10 Pain Relevance 0.10
Capsaicin induced an increase of sICAM-1 release into the culture medium at concentration >/=100 microM.
Localization (release) of sICAM-1 associated with qutenza
3) Confidence 0.81 Published 2000 Journal Toxicology Section Abstract Doc Link 10837931 Disease Relevance 0.59 Pain Relevance 1.02
The cytotoxicity and inflammatory properties of capsaicin were evaluated by measuring the capsaicin-stimulated release of soluble intercellular adhesion molecule-1 levels (sICAM-1) into the culture medium; production of reactive oxygen species measured by quantification of lipoperoxidation in endothelial cell membranes; and genotoxicity measured using the comet assay and the DNA fragmentation assay.
Localization (release) of sICAM-1 in endothelial cell associated with qutenza, inflammation and adhesions
4) Confidence 0.81 Published 2000 Journal Toxicology Section Abstract Doc Link 10837931 Disease Relevance 0.52 Pain Relevance 0.90
The results indicate that ICAM-1 targeted immunoliposomes may be used as carriers for the intracellular delivery of anti-inflammatory drugs to sites of inflammation characterised by an increased expression of ICAM-1.
Localization (targeted) of ICAM-1 associated with inflammation and cinod
5) Confidence 0.75 Published 1999 Journal Biochim. Biophys. Acta Section Abstract Doc Link 10407086 Disease Relevance 0.34 Pain Relevance 0.14
Correspondingly, a dramatic increase in ICAM-1 release from the surface of cultured small-airway epithelial cells of smokers compared to cells from non-smokers (356 pg 106 cells-1 vs 113 pg 106cells-1) was noted.
Localization (release) of ICAM-1 in epithelial cells associated with nicotine addiction
6) Confidence 0.73 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.73 Pain Relevance 0
Correspondingly, a dramatic increase in ICAM-1 release from the surface of cultured small-airway epithelial cells of smokers compared to cells from non-smokers (356 pg 106 cells-1 vs 113 pg 106cells-1) was noted.
Localization (release) of ICAM-1 in epithelial cells associated with nicotine addiction
7) Confidence 0.73 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.73 Pain Relevance 0
The cytotoxicity and inflammatory properties of capsaicin were evaluated by measuring the capsaicin-stimulated release of soluble intercellular adhesion molecule-1 levels (sICAM-1) into the culture medium; production of reactive oxygen species measured by quantification of lipoperoxidation in endothelial cell membranes; and genotoxicity measured using the comet assay and the DNA fragmentation assay.
Localization (release) of soluble intercellular adhesion molecule-1 in endothelial cell associated with qutenza, inflammation and adhesions
8) Confidence 0.70 Published 2000 Journal Toxicology Section Abstract Doc Link 10837931 Disease Relevance 0.52 Pain Relevance 0.89
As observed in Figure 1 for endometria obtained across the menstrual cycle, Figure 2 demonstrates that imunoreactive ICAM-1 was also localized specifically to the endothelium of LTPOC-derived endometrium with staining intensity that was equivalent among various vessel types and independent of both steroidal and inflammatory state.
Localization (localized) of ICAM in endometrium associated with inflammation
9) Confidence 0.70 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1403781 Disease Relevance 0.27 Pain Relevance 0.17
However, the majority of studies have found no evidence for alternate mRNA species in humans, and the predominant theory is that sICAM-1 is released from the cell surface following proteolysis of the cell-bound form, at a defined site [45,48,49,184].
Localization (released) of sICAM-1
10) Confidence 0.68 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 0.32 Pain Relevance 0.04
However, the majority of studies have found no evidence for alternate mRNA species in humans, and the predominant theory is that sICAM-1 is released from the cell surface following proteolysis of the cell-bound form, at a defined site [45,48,49,184].
Localization (released) of sICAM-1
11) Confidence 0.68 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 0.32 Pain Relevance 0.04
In this study, we show that human cere-bromicrovascular endothelial cells (HCEC) subjected to a 4 h in vitro ischemia (hypoxia + glucose deprivation) followed by a 4-24 h recovery express elevated levels of ICAM-1, IL-8, and MCP-1 mRNAs (semi-quantitative RT-PCR) and secrete increased amounts of the immunoreactive chemokines IL-8 and MCP-1 (ELISA).
Localization (levels) of ICAM-1 in HCEC associated with chemokine, hypoxia and ischemia
12) Confidence 0.66 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 0.96 Pain Relevance 0.43
and bacterial lipopolysaccharide (LPS), increase the expression of cell adhesion molecules (CAMs) including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin on endothelial cells.2 Thus, upon inflammatory stimulation, the endothelial barrier function is rapidly lost and preformed P-selectin is translocated to the luminal surface of endothelial cells, followed by expression and release of E-selectin, ICAM-1, and VCAM-1 – substances that regulate the attachment and trans-endothelial migration of leukocytes.
Localization (release) of ICAM in endothelial cells associated with inflammation and adhesions
13) Confidence 0.65 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2828103 Disease Relevance 1.81 Pain Relevance 0.25
sICAM-1 and disease
Localization (disease) of sICAM-1 associated with disease
14) Confidence 0.64 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.24 Pain Relevance 0.27
sICAM-1 and disease
Localization (disease) of sICAM-1 associated with disease
15) Confidence 0.64 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.24 Pain Relevance 0.27
Cigarette smoke exposure resulted in a significant increase (up to 175%) in sICAM-1 release from primary explant cultures of human bronchial epithelial cells obtained from never-smokers, or smokers with COPD, but not in cultured bronchial epithelial cells from smokers with normal pulmonary function [101].
Localization (release) of sICAM-1 in epithelial cells associated with nicotine addiction and chronic obstructive pulmonary disease
16) Confidence 0.64 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.83 Pain Relevance 0.07
Cigarette smoke exposure resulted in a significant increase (up to 175%) in sICAM-1 release from primary explant cultures of human bronchial epithelial cells obtained from never-smokers, or smokers with COPD, but not in cultured bronchial epithelial cells from smokers with normal pulmonary function [101].
Localization (release) of sICAM-1 in epithelial cells associated with nicotine addiction and chronic obstructive pulmonary disease
17) Confidence 0.64 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.83 Pain Relevance 0.07
ICAM-1 and BCAM concentrations were measured in the SILAP standard, as well.
Localization (measured) of ICAM-1
18) Confidence 0.60 Published 2009 Journal Journal of Proteome Research Section Body Doc Link PMC2652408 Disease Relevance 0.37 Pain Relevance 0
induced eosinophil degranulation, cytokines release and adhesion to VCAM-1, ICAM-1 and IgG.


Localization (release) of ICAM-1 in eosinophil associated with adhesions and cytokine
19) Confidence 0.53 Published 2005 Journal Clin Mol Allergy Section Body Doc Link PMC1131914 Disease Relevance 0.90 Pain Relevance 0.50
-induced ECP release and their adhesion to immobilised VCAM-1, ICAM-1 and IgG.
Localization (immobilised) of ICAM-1 associated with adhesions
20) Confidence 0.53 Published 2005 Journal Clin Mol Allergy Section Body Doc Link PMC1131914 Disease Relevance 0.62 Pain Relevance 0.45

General Comments

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