INT65716

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Context Info
Confidence 0.54
First Reported 1996
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.37
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
brain 1
platelet 1
Prnp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sSRI 22 99.00 Very High Very High Very High
fluoxetine 18 97.36 Very High Very High Very High
antidepressant 4 87.88 High High
tolerance 5 77.76 Quite High
depression 4 61.80 Quite High
Serotonin 4 59.72 Quite High
Angina 1 58.00 Quite High
Disease Link Frequency Relevance Heat
Hemorrhage 2 96.68 Very High Very High Very High
Depression 4 61.80 Quite High
Myocardial Infarction 1 59.04 Quite High
Cv General 3 Under Development 1 58.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results obtained confirm that the FST increases immobility; furthermore they show a parallel and significant decrease in cerebral (brain homogenate) and peripheral (in platelet-rich plasma, PRP) voltammetric 5-HT levels following the FST in naive rats.
Negative_regulation (decrease) of PRP in brain
1) Confidence 0.54 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 11880895 Disease Relevance 0.06 Pain Relevance 0.67
In addition, subchronic treatment with fluoxetine was followed by a significant increase in 5-HT levels in PRP, while the same SSRI treatment performed within the FST resulted in a decrease in the 5-HT levels in PRP.
Negative_regulation (decrease) of PRP associated with ssri and fluoxetine
2) Confidence 0.47 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 11880895 Disease Relevance 0 Pain Relevance 0.68
NTG also decreased the PRP platelet concentration by 30% in 8 h, whereas D5W had no effect.
Negative_regulation (decreased) of PRP in platelet
3) Confidence 0.31 Published 1996 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8877591 Disease Relevance 0.30 Pain Relevance 0.24

General Comments

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