INT65724

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Context Info
Confidence 0.33
First Reported 1996
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 2.94
Pain Relevance 8.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1) extracellular region (Pnoc) plasma membrane (Oprl1)
signal transducer activity (Oprl1)
Anatomy Link Frequency
spinal cord 1
Pnoc (Mus musculus)
Oprl1 (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 30 100.00 Very High Very High Very High
Opioid 29 100.00 Very High Very High Very High
opioid receptor 12 100.00 Very High Very High Very High
Neuropeptide 11 100.00 Very High Very High Very High
allodynia 13 99.20 Very High Very High Very High
Hyperalgesia 11 99.20 Very High Very High Very High
Pain 19 98.76 Very High Very High Very High
Spinal cord 8 95.88 Very High Very High Very High
Lasting pain 1 95.04 Very High Very High Very High
Intracerebroventricular 2 87.76 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 13 99.20 Very High Very High Very High
Hyperalgesia 11 99.20 Very High Very High Very High
Pain 17 98.76 Very High Very High Very High
Injury 1 93.92 High High
Stress 6 80.16 Quite High
Nociception 10 73.20 Quite High
INFLAMMATION 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Orphanin FQ (OFQ) is the recently isolated endogenous ligand for the orphan opioid-like receptor, LC132.
Orphanin FQ Binding (ligand) of LC132 associated with orphanin and opioid
1) Confidence 0.33 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8878101 Disease Relevance 0.18 Pain Relevance 0.99
Orphanin FQ (OFQ) is the recently isolated endogenous ligand for the orphan opioid-like receptor, LC132.
OFQ Binding (ligand) of LC132 associated with orphanin and opioid
2) Confidence 0.33 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8878101 Disease Relevance 0.18 Pain Relevance 0.99
Orphanin FQ (OFQ), the endogenous ligand for the orphan opioid receptor, LC132, was recently isolated and characterized.
OFQ Binding (ligand) of LC132 associated with orphanin and opioid receptor
3) Confidence 0.27 Published 1996 Journal Neuroreport Section Abstract Doc Link 8930972 Disease Relevance 0.23 Pain Relevance 0.95
Orphanin FQ (OFQ), the endogenous ligand for the orphan opioid receptor, LC132, was recently isolated and characterized.
Orphanin FQ Binding (ligand) of LC132 associated with orphanin and opioid receptor
4) Confidence 0.27 Published 1996 Journal Neuroreport Section Abstract Doc Link 8930972 Disease Relevance 0.23 Pain Relevance 0.95
The neuropeptide nociceptin, also known as orphanin FQ, is an endogenous ligand for the orphan opioid-like receptor which induces both hyperalgesia and allodynia when administered by injection through the theca of the spinal cord into the subarachnoid space (that is, intrathecally).
nociceptin Binding (ligand) of orphan opioid-like receptor in spinal cord associated with hyperalgesia, allodynia, orphanin, neuropeptide, opioid and spinal cord
5) Confidence 0.27 Published 1998 Journal Nature Section Abstract Doc Link 9521323 Disease Relevance 1.03 Pain Relevance 1.35
Its presence was expected by analysis of the precursor for the neuropeptide nociceptin or orphanin FQ (Noc/OFQ), previously identified as an endogenous ligand for the orphan opioid receptor-like receptor.
orphanin FQ Binding (ligand) of orphan opioid receptor-like receptor associated with orphanin, neuropeptide and opioid receptor
6) Confidence 0.15 Published 2000 Journal Peptides Section Abstract Doc Link 10998544 Disease Relevance 0.37 Pain Relevance 0.85
Its presence was expected by analysis of the precursor for the neuropeptide nociceptin or orphanin FQ (Noc/OFQ), previously identified as an endogenous ligand for the orphan opioid receptor-like receptor.
neuropeptide nociceptin Binding (ligand) of orphan opioid receptor-like receptor associated with orphanin, neuropeptide and opioid receptor
7) Confidence 0.15 Published 2000 Journal Peptides Section Abstract Doc Link 10998544 Disease Relevance 0.37 Pain Relevance 0.85
Orphanin FQ (OFQ) is the recently isolated endogenous ligand for the orphan opioid-like receptor, LC132.
OFQ Binding (ligand) of orphan opioid-like receptor associated with orphanin and opioid
8) Confidence 0.13 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8878101 Disease Relevance 0.18 Pain Relevance 0.94
Orphanin FQ (OFQ) is the recently isolated endogenous ligand for the orphan opioid-like receptor, LC132.
Orphanin FQ Binding (ligand) of orphan opioid-like receptor associated with orphanin and opioid
9) Confidence 0.13 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8878101 Disease Relevance 0.18 Pain Relevance 0.94

General Comments

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