INT6573

Context Info Confidence 0.45 First Reported 1984 Last Reported 2008 Negated 5 Speculated 4 Reported most in Abstract Documents 19 Total Number 23 Disease Relevance 6.16 Pain Relevance 8.71

nuclear envelope (Ptgs1) aging (Ptgs1) Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)

Anatomy Link Frequency liver 3 paw 2 pancreas 2 melanocyte 2 neutrophils 2 Ptgs1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat aspirin 36 100.00 diclofenac 6 100.00 cINOD 42 99.90 Morphine 16 99.84 Pain 4 99.24 Thoracotomy 2 99.14 Clonidine 19 99.12 Hyperalgesia 5 98.92 Paracetamol 4 98.76 isoflurane 4 98.68

Disease Link Frequency Relevance Heat Pain 4 99.24 Emergencies 1 99.16 Hyperalgesia 5 98.92 INFLAMMATION 33 98.64 Hepatotoxicity 4 98.28 Injury 6 97.92 Pressure And Volume Under Development 4 97.08 Death 1 94.40 Fever 1 94.08 Increased Venous Pressure Under Development 2 92.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The antagonistic effect of salicylic acid (SA), the major metabolite of aspirin, on aspirin (ASA)-induced inhibition of cyclooxygenase has been recognized in vivo and in vitro.

Regulation (effect) of Negative_regulation (inhibition) of cyclooxygenase associated with aspirin

1) Confidence 0.45 Published 1994 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 7846108 Disease Relevance 0 Pain Relevance 0.37

The aim of this study was to investigate the role of cyclooxygenase (COX) inhibition in intestinal motility and in the extent of tissue injury of the small intestine and liver with the use of various COX inhibitors.

Spec (investigate) Regulation (role) of Spec (investigate) Negative_regulation (inhibition) of cyclooxygenase in liver associated with injury

2) Confidence 0.24 Published 2002 Journal Burns Section Abstract Doc Link 11996850 Disease Relevance 0.31 Pain Relevance 0

Experiments were performed to investigate the effects of acute cyclooxygenase inhibition on renal hemodynamics in mid and late pregnant rats.

Spec (investigate) Regulation (effects) of Spec (investigate) Negative_regulation (inhibition) of cyclooxygenase

3) Confidence 0.24 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3111275 Disease Relevance 0 Pain Relevance 0

The effect of [3,4-di(4-methoxyphenyl)-5-isoxazolyl] acetic acid (mofezolac), a potent and highly preferential inhibitor of cyclooxygenase-1, and N-[2-(cyclohexyloxy)-4-nitrophenyl]methanesulphonamide (NS-398), a selective inhibitor of cyclooxygenase-2, on DNA fragmentation and cyclooxygenase-2 mRNA expression was weak compared to the effect of indomethacin or sodium diclofenac.

Regulation (effect) of Negative_regulation (inhibitor) of cyclooxygenase-1 associated with diclofenac

4) Confidence 0.23 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9851595 Disease Relevance 0.48 Pain Relevance 0.69

Effects of inhibitors of phospholipase A2, cyclooxygenase and thromboxane synthetase on paracetamol hepatotoxicity in the rat.

Regulation (Effects) of Negative_regulation (inhibitors) of cyclooxygenase associated with paracetamol and hepatotoxicity

5) Confidence 0.23 Published 1989 Journal Eicosanoids Section Title Doc Link 2516744 Disease Relevance 0.44 Pain Relevance 0.25

The role of cyclooxygenase inhibition in the effect of alpha-melanocyte-stimulating hormone on reactive oxygen species production by rat peritoneal neutrophils.

Regulation (role) of Negative_regulation (inhibition) of cyclooxygenase in melanocyte

6) Confidence 0.19 Published 2004 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Title Doc Link 15172677 Disease Relevance 0 Pain Relevance 0.07

Effect of antirheumatics and inhibitors of cyclooxygenase, lipoxygenases and thromboxane synthetase on cobra venom factor rat paw edema.

Regulation (Effect) of Negative_regulation (inhibitors) of cyclooxygenase in paw associated with pressure and volume under development

7) Confidence 0.19 Published 1984 Journal Biomed. Biochim. Acta Section Title Doc Link 6440543 Disease Relevance 0.19 Pain Relevance 0.18

Inhibition of cyclooxygenase by diclofenac did not change the amplitude of the clonidine-induced contractions observed both in the presence and absence of L-NNA.

Neg (not) Regulation (change) of Negative_regulation (Inhibition) of cyclooxygenase associated with diclofenac and clonidine

8) Confidence 0.17 Published 2006 Journal J Smooth Muscle Res Section Abstract Doc Link 17001113 Disease Relevance 0.13 Pain Relevance 1.10

The effect of alpha-MSH on reactive oxygen species (ROS) production by rat peritoneal neutrophils and the effect of cyclooxygenase (COX) inhibition were investigated using the chemiluminescence (CL) technique.

Regulation (effect) of Negative_regulation (inhibition) of cyclooxygenase in neutrophils

9) Confidence 0.14 Published 2004 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 15172677 Disease Relevance 0 Pain Relevance 0.07

However, these activities are relatively modest and do not appear to account for the antiinflammatory effects of NSAID; indeed, mechanisms for these effects that do not depend on cyclooxygenase inhibition have been advanced.

Neg (not) Regulation (depend) of Negative_regulation (inhibition) of cyclooxygenase associated with inflammation and cinod

10) Confidence 0.14 Published 1991 Journal J Rheumatol Suppl Section Abstract Doc Link 1903811 Disease Relevance 0.94 Pain Relevance 0.47

Effect of cyclooxygenase and nitric oxide synthase inhibitors on streptozotocin-induced hyperalgesia in rats.

Regulation (Effect) of Negative_regulation (inhibitors) of cyclooxygenase associated with hyperalgesia

11) Confidence 0.13 Published 2008 Journal Pharmacology Section Title Doc Link 17989504 Disease Relevance 0.36 Pain Relevance 0.40

A synergistic effect of nonselective cyclooxygenase (COX) inhibitors on morphine-induced decrease of isoflurane minimum alveolar concentration (MAC(ISO)) has been observed in the rat.

Regulation (effect) of Negative_regulation (inhibitors) of cyclooxygenase associated with isoflurane and morphine

12) Confidence 0.13 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 14742370 Disease Relevance 0 Pain Relevance 0.69

Effects of phospholipase A2 inhibitor, cyclooxygenase inhibitor and lipoxygenase inhibitor on glucagon secretion induced by the alpha 2-adrenergic agonist clonidine were studied in the isolated perfused rat pancreas.

Regulation (Effects) of Negative_regulation (inhibitor) of cyclooxygenase in pancreas associated with agonist and clonidine

13) Confidence 0.11 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.38

The present study was designed to examine the effect of benoxaprofen, a dual lipoxygenase and cyclooxygenase inhibitor, in the same canine endotoxic model (LD100) and compare it to ibuprofen treatment.

Spec (examine) Regulation (effect) of Spec (examine) Negative_regulation (inhibitor) of cyclooxygenase

14) Confidence 0.09 Published 1985 Journal Circ. Shock Section Abstract Doc Link 3919960 Disease Relevance 0.25 Pain Relevance 0.09

The aim of this study was to investigate the role of cyclooxygenase (COX) inhibition in intestinal motility and in the extent of tissue injury of the small intestine and liver with the use of various COX inhibitors.

Spec (investigate) Regulation (role) of in small intestine Spec (investigate) Negative_regulation (inhibition) of cyclooxygenase in liver associated with injury

15) Confidence 0.08 Published 2002 Journal Burns Section Abstract Doc Link 11996850 Disease Relevance 0.31 Pain Relevance 0

These effects of NSAIDs were not dependent on cyclooxygenase inhibition.

Neg (not) Regulation (dependent) of Negative_regulation (inhibition) of cyclooxygenase associated with cinod

16) Confidence 0.04 Published 1999 Journal FEBS Lett. Section Abstract Doc Link 10100866 Disease Relevance 0.16 Pain Relevance 0.55

OBJECTIVE: To compare the analgesic efficacy of a traditional epidurally delivered bupivacaine/fentanyl combination with a repeat bolus intrathecal morphine technique in the management of post-thoracotomy pain and to assess further the effect of cyclooxygenase (COX) inhibition on both modalities.

Regulation (effect) of Negative_regulation (inhibition) of cyclooxygenase associated with pain, analgesic, thoracotomy, morphine and intrathecal

17) Confidence 0.03 Published 2002 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 12407615 Disease Relevance 0.17 Pain Relevance 0.62

These inhibitions were independent on cyclooxygenase inhibition.

Neg (independent) Regulation (independent) of Negative_regulation (inhibition) of cyclooxygenase

18) Confidence 0.02 Published 2006 Journal Exp. Dermatol. Section Abstract Doc Link 17083365 Disease Relevance 0.72 Pain Relevance 0.99

Other possible sites of action that are not directly related to cyclooxygenase inhibition have been suggested based on observations made in vitro using high concentrations of aspirin and sodium salicylate.

Neg (not) Regulation (related) of Negative_regulation (inhibition) of cyclooxygenase associated with aspirin

19) Confidence 0.01 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12106797 Disease Relevance 0.21 Pain Relevance 0.44

Studies have shown that both therapeutic and side effects of NSAIDs are dependent on cyclooxygenase (COX) inhibition.

Regulation (dependent) of Negative_regulation (inhibition) of cyclooxygenase associated with cinod

20) Confidence 0.01 Published 2007 Journal Pharmacol Rep Section Abstract Doc Link 17652824 Disease Relevance 0.98 Pain Relevance 0.54

General Comments

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