INT65731

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2011
Negated 11
Speculated 3
Reported most in Body
Documents 234
Total Number 237
Disease Relevance 63.82
Pain Relevance 109.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
neurons 18
brain 13
central nervous system 12
dentate gyrus 8
neuronal 6
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 6036 100.00 Very High Very High Very High
agonist 3172 100.00 Very High Very High Very High
Endocannabinoid 2818 100.00 Very High Very High Very High
Analgesic 2170 100.00 Very High Very High Very High
tolerance 1403 100.00 Very High Very High Very High
antagonist 1240 100.00 Very High Very High Very High
depression 1216 100.00 Very High Very High Very High
Cannabinoid receptor 1008 100.00 Very High Very High Very High
analgesia 898 100.00 Very High Very High Very High
Pain 627 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 1469 100.00 Very High Very High Very High
Depression 1327 100.00 Very High Very High Very High
Cognitive Disorder 188 100.00 Very High Very High Very High
Neuroblastoma 13 100.00 Very High Very High Very High
Vibrio Infection 3 100.00 Very High Very High Very High
Targeted Disruption 610 99.96 Very High Very High Very High
Diabetes Mellitus 787 99.84 Very High Very High Very High
Cancer Pain 30 99.50 Very High Very High Very High
Neuropathic Pain 702 99.44 Very High Very High Very High
Bone Cancer 29 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study examined whether selective spinal cannabinoid receptor 1 (CB1) activation alleviates bone cancer pain and also examined the spinal expression of CB1.
Spec (examined) Gene_expression (expression) of CB1 in spinal associated with cancer pain, cannabinoid receptor and bone cancer
1) Confidence 0.78 Published 2009 Journal Anesthesiology Section Abstract Doc Link 19512863 Disease Relevance 0.85 Pain Relevance 0.59
Reduction of bone cancer pain by activation of spinal cannabinoid receptor 1 and its expression in the superficial dorsal horn of the spinal cord in a murine model of bone cancer pain.
Gene_expression (expression) of cannabinoid receptor 1 in dorsal horn associated with cannabinoid receptor, cancer pain, analgesic, dorsal horn, bone cancer and spinal cord
2) Confidence 0.78 Published 2009 Journal Anesthesiology Section Title Doc Link 19512863 Disease Relevance 0.76 Pain Relevance 1.05
In immunohistochemical experiments, although mu-opioid receptor 1 expression was reduced in the superficial dorsal horn ipsilateral to the site of implantation of sarcoma cells, CB1 expression was preserved.
Gene_expression (expression) of CB1 in dorsal horn
3) Confidence 0.78 Published 2009 Journal Anesthesiology Section Body Doc Link 19512863 Disease Relevance 0.13 Pain Relevance 0
In addition, CB1 was mainly expressed in the axon terminals, but not in the dendritic process in the superficial dorsal horn.
Neg (not) Gene_expression (expressed) of CB1 in dorsal horn
4) Confidence 0.78 Published 2009 Journal Anesthesiology Section Body Doc Link 19512863 Disease Relevance 0.12 Pain Relevance 0
CB1 is also expressed heavily in the distal terminals of the MSNs from the direct and indirect pathway, which synapse onto the substantia nigra pars reticulate and the globus pallidus, respectively (Sanudo-Pena et al., 1999).
Gene_expression (expressed) of CB1 in substantia nigra associated with substantia nigra
5) Confidence 0.78 Published 2008 Journal Frontiers in Neuroscience Section Body Doc Link PMC2622741 Disease Relevance 0.28 Pain Relevance 0.31
Furthermore, the expression of CB1 receptors across the striatum displays a medial-lateral gradient of increased expression, with the highest expression in the dorsolateral striatum (Gerdeman et al., 2003; Herkenham et al., 1991), which has been shown to be necessary for habit formation (Figure 3D).
Gene_expression (expression) of CB1 in striatum
6) Confidence 0.78 Published 2008 Journal Frontiers in Neuroscience Section Body Doc Link PMC2622741 Disease Relevance 0 Pain Relevance 0.29
Although CB1 receptors are one of the most-abundant G-protein coupled receptors in the brain and are expressed almost ubiquitously, we have already described the dorsolateral striatum as a good candidate for the “where” question.
Gene_expression (expressed) of CB1 in striatum
7) Confidence 0.78 Published 2008 Journal Frontiers in Neuroscience Section Body Doc Link PMC2622741 Disease Relevance 0.43 Pain Relevance 0.33
Given the extraordinary high expression of CB1 on GABAergic interneurons, the modulation of the activity of these neurons is generally believed to mediate most of the effects of exogenously administered and endogenously released cannabinoids [23].
Gene_expression (expression) of CB1 in neurons associated with cannabinoid and gabaergic
8) Confidence 0.78 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0.13 Pain Relevance 0.61
In the brain, where THC and other cannabinoids exert most of their behavioural effects, CB1 receptors are expressed at different levels in different neuronal subpopulations.
Gene_expression (expressed) of CB1 in brain associated with cannabinoid
9) Confidence 0.78 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0.17 Pain Relevance 0.69
CB1 cannabinoid receptors are widely expressed in the central nervous system and, importantly, are present in different neuronal subpopulations [11,17,24,25,50].
Gene_expression (expressed) of CB1 in central nervous system associated with cannabinoid receptor and central nervous system
10) Confidence 0.78 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0 Pain Relevance 0.35
To this aim, we used a combined genetic and pharmacological approach and analysed the effects of THC in previously described CB1 conditional mutant mice [26,27] and in newly generated mice, which lacked CB1 expression in the majority of striatal MSNs and a subset of glutamatergic neurons in layer VI of the neocortex.
Neg (lacked) Gene_expression (expression) of CB1 in glutamatergic neurons
11) Confidence 0.78 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0.08 Pain Relevance 0.19
Taken together (Table 2 and Figure 8), our genetic and pharmacological results show that (1) various pharmacological effects of cannabinoids are mediated by different neuronal circuits, which can be dissected by genetic approaches; (2) GABAergic interneurons do not appear to mediate these effects of THC; (3) cortical glutamatergic neurons mediate a large portion of hypolocomotor effects of cannabinoids; (4) similarly, CB1 expression in cortical glutamatergic neurons plays a prominent role in mediating the hypothermic effects of THC, with a possible partial involvement of a subpopulation of MSNs; (5) the simultaneous activation of CB1 receptors located on striatal neurons and glutamatergic neocortical neurons is likely to be necessary to exert the cataleptic effect of THC; and (6) analgesic effects depend on principal neurons of the central nervous system, but their precise identity is not yet clearly identifiable.
Gene_expression (expression) of CB1 in neuronal associated with analgesic, gabaergic, cannabinoid and central nervous system
12) Confidence 0.78 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0.06 Pain Relevance 0.39
In the brain, the expression of CB1 correlates with the psychotropic effects of cannabinoids [11,22].
Gene_expression (expression) of CB1 in brain associated with cannabinoid
13) Confidence 0.78 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0.19 Pain Relevance 0.76
However, CB1 receptors are also expressed in other neuronal subpopulations, including, among others, glutamatergic cortical principal neurons [24–30].
Gene_expression (expressed) of CB1 in neurons
14) Confidence 0.78 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0.14 Pain Relevance 0.64
Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain.
Gene_expression (Expression) of CB1 in neuronal associated with cannabinoid receptor and cannabinoid
15) Confidence 0.77 Published 1999 Journal Eur. J. Neurosci. Section Title Doc Link 10594647 Disease Relevance 0.19 Pain Relevance 0.55
These effects correlate with the expression of the cannabinoid receptor 1 (CB1) and with the presence of endogenous cannabinoids in the brain.
Gene_expression (expression) of cannabinoid receptor 1 in brain associated with cannabinoid receptor and cannabinoid
16) Confidence 0.77 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10594647 Disease Relevance 0.20 Pain Relevance 0.43
These effects correlate with the expression of the cannabinoid receptor 1 (CB1) and with the presence of endogenous cannabinoids in the brain.
Gene_expression (expression) of CB1 in brain associated with cannabinoid receptor and cannabinoid
17) Confidence 0.77 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10594647 Disease Relevance 0.20 Pain Relevance 0.43
CB1 is very highly coexpressed with CCK.
Gene_expression (coexpressed) of CB1 associated with cholecystokinin
18) Confidence 0.77 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10594647 Disease Relevance 0 Pain Relevance 0.74
Immunocytochemical and electrophysiological studies revealed that in the hippocampus CB1 receptors are expressed on axon terminals of GABAergic inhibitory interneurons (Tsou et al., 1999; Katona et al., 1999) and activation of these receptors decreases GABA release (Hájos et al., 2000).
Gene_expression (expressed) of CB1 in inhibitory interneurons associated with gaba, gabaergic and hippocampus
19) Confidence 0.77 Published 2001 Journal Neuroscience Section Abstract Doc Link 11564411 Disease Relevance 0 Pain Relevance 0.56
The CB1 receptors are abundantly expressed in the nervous system, whereas CB2 receptors are limited to lymphoid organs (Matsuda et al., 1990; Munro et al., 1993).
Gene_expression (expressed) of CB1 in nervous system
20) Confidence 0.77 Published 2001 Journal Neuroscience Section Abstract Doc Link 11564411 Disease Relevance 0 Pain Relevance 0.46

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