INT65732

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Context Info
Confidence 0.47
First Reported 1996
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 7.28
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Msr1) plasma membrane (Msr1)
Anatomy Link Frequency
apoptotic cells 2
brain 1
spleen 1
Msr1 (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 1 100.00 Very High Very High Very High
antagonist 9 99.98 Very High Very High Very High
Physical dependence 1 99.80 Very High Very High Very High
Cannabinoid 19 99.60 Very High Very High Very High
agonist 14 99.48 Very High Very High Very High
fluoxetine 2 99.40 Very High Very High Very High
Cannabinoid receptor 7 96.52 Very High Very High Very High
narcan 3 96.52 Very High Very High Very High
Opioid 2 95.72 Very High Very High Very High
headache 3 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 56 100.00 Very High Very High Very High
Cognitive Disorder 2 100.00 Very High Very High Very High
Drug Dependence 1 99.80 Very High Very High Very High
Death 11 98.84 Very High Very High Very High
Coma 6 98.44 Very High Very High Very High
Bordatella Infection 2 97.40 Very High Very High Very High
Convulsion 9 96.64 Very High Very High Very High
Psychosis 3 96.24 Very High Very High Very High
Apoptosis 10 95.96 Very High Very High Very High
Headache 3 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SR-A receptors bind lipopolysaccharide from Gram-negative and lipoteichoic acid from Gram-positive bacteria [4].
SR-A Binding (bind) of
1) Confidence 0.47 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1562429 Disease Relevance 1.21 Pain Relevance 0.06
The class A macrophage scavenger receptor (SR-A) is the prototypic member of a large family of membrane receptors that bind oxidized low density lipoprotein and a wide variety of other ligands many of which are derived from apoptotic cells and pathogens [4].
SR-A Binding (bind) of in apoptotic cells associated with apoptosis
2) Confidence 0.36 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1562429 Disease Relevance 1.90 Pain Relevance 0.09
Importantly, SR58611A was devoid of side effects related to cognition (as shown in the Morris water maze and object recognition tasks), motor activity (in the rotarod), alcohol interaction, or physical dependence.
SR58611A Binding (interaction) of associated with cognitive disorder, physical dependence and alcohol
3) Confidence 0.26 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17460614 Disease Relevance 1.20 Pain Relevance 0.54
The class A macrophage scavenger receptor (SR-A) is the prototypic member of a large family of membrane receptors that bind oxidized low density lipoprotein and a wide variety of other ligands many of which are derived from apoptotic cells and pathogens [4].
scavenger receptor Binding (bind) of in apoptotic cells associated with apoptosis
4) Confidence 0.17 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1562429 Disease Relevance 1.92 Pain Relevance 0.10
Synthesis of an antagonist, SR141716A, that selectively binds to brain cannabinoid (CB(1)) receptors without producing cannabimimetic activity in vivo, suggests that recognition and activation of cannabinoid receptors are separable events.
SR141716A Binding (binds) of in brain associated with cannabinoid receptor, cannabinoid and antagonist
5) Confidence 0.13 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11181936 Disease Relevance 0.07 Pain Relevance 0.28
Transgenic (Tg) DN MSR RAGE and Tg DN PPET RAGE mice were prepared and characterized as previously described (20,22).
DN MSR Binding (characterized) of associated with targeted disruption
6) Confidence 0.10 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 0.67 Pain Relevance 0
Cannabinoid agonists and the CB1-R antagonist SR141716A effectively competed for anandamide binding in the blastocyst.
SR141716A Binding (binding) of associated with antagonist, cannabinoid and agonist
7) Confidence 0.05 Published 1996 Journal Biol. Reprod. Section Abstract Doc Link 8879486 Disease Relevance 0 Pain Relevance 0.53
SR141716 proved to bind directly to MORs with low affinity (IC(50) = 5.7 microM).
SR141716 Binding (bind) of
8) Confidence 0.00 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19448142 Disease Relevance 0.23 Pain Relevance 0.53
After oral administration, SR147778 displaced the ex vivo [3H]-CP 55,940 binding to mouse brain membranes (ED50 = 3.8 mg/kg) with a long duration of action, whereas it did not interact with the CB2 receptor expressed in the mouse spleen.
SR147778 Neg (not) Binding (interact) of in spleen
9) Confidence 0.00 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15131245 Disease Relevance 0.09 Pain Relevance 0.28

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