INT65733

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2011
Negated 7
Speculated 4
Reported most in Body
Documents 125
Total Number 130
Disease Relevance 40.27
Pain Relevance 67.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
brain 8
neurons 5
spinal 4
hypothalamus 4
dentate gyrus 3
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 2363 100.00 Very High Very High Very High
Endocannabinoid 1942 100.00 Very High Very High Very High
agonist 1144 100.00 Very High Very High Very High
antagonist 862 100.00 Very High Very High Very High
Cannabinoid receptor 755 100.00 Very High Very High Very High
Analgesic 515 100.00 Very High Very High Very High
addiction 137 99.96 Very High Very High Very High
Cancer pain 36 99.92 Very High Very High Very High
Neuropeptide 19 99.92 Very High Very High Very High
MU agonist 8 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cough 392 100.00 Very High Very High Very High
Morphine Dependence 1 99.96 Very High Very High Very High
Cancer Pain 36 99.92 Very High Very High Very High
Stress 467 99.90 Very High Very High Very High
Bone Cancer 37 99.82 Very High Very High Very High
Neurodegenerative Disease 658 99.76 Very High Very High Very High
Heart Rate Under Development 5 99.74 Very High Very High Very High
Depression 1000 99.60 Very High Very High Very High
Status Epilepticus 407 99.48 Very High Very High Very High
Hypotension 7 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduction of bone cancer pain by activation of spinal cannabinoid receptor 1 and its expression in the superficial dorsal horn of the spinal cord in a murine model of bone cancer pain.
Positive_regulation (activation) of cannabinoid receptor 1 in dorsal horn associated with cannabinoid receptor, cancer pain, analgesic, dorsal horn, bone cancer and spinal cord
1) Confidence 0.70 Published 2009 Journal Anesthesiology Section Title Doc Link 19512863 Disease Relevance 0.76 Pain Relevance 1.05
Cannabinoids prevent the formation of LTP in the amygdala via activation of CB1 receptors.
Positive_regulation (activation) of CB1 in amygdala
2) Confidence 0.70 Published 2005 Journal Schmerz Section Body Doc Link 16328555 Disease Relevance 0 Pain Relevance 0
Cannabinoids, including the endogenous ligand anandamide, elicit pronounced hypotension and bradycardia through the activation of CB1 cannabinoid receptors.
Positive_regulation (activation) of CB1 associated with heart rate under development, cannabinoid receptor, cannabinoid and hypotension
3) Confidence 0.70 Published 2000 Journal Hypertension Section Abstract Doc Link 10679517 Disease Relevance 0.39 Pain Relevance 0.25
We found no significant effects of CB1R activation on overall sEPSCs or mEPSCs in control mice, but effects of CB1R activation specifically on mossy cell inputs were not tested.
Positive_regulation (activation) of CB1R
4) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.29 Pain Relevance 0.41
Action potential-driven IPSCs, evoked by pharmacological stimulation of a subset of interneurons, were also decreased by CB1 receptor activation.
Positive_regulation (activation) of CB1 receptor in interneurons associated with action potential and cannabinoid receptor
5) Confidence 0.69 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10998107 Disease Relevance 0.07 Pain Relevance 0.97
In the hippocampus of wild type mice we found an upregulation of CB1 receptor mRNA in the ENR and RUN mice along with an increase in Nestin mRNA only in the RUN paradigm.
Positive_regulation (upregulation) of CB1 receptor in hippocampus associated with hippocampus
6) Confidence 0.69 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.48 Pain Relevance 0.13
Along the same line, (7) voluntary wheel running increased CB1 receptor mRNA in the hippocampus.
Positive_regulation (increased) of CB1 receptor in hippocampus associated with hippocampus
7) Confidence 0.69 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.68 Pain Relevance 0.15
We found (4) the pro-neurogenic effect of CBD to be dependent on the CB1 receptor, which (5) shows a widespread expression over the entire dentate gyrus, including the neuronal precursor cells.
Positive_regulation (dependent) of CB1 receptor in precursor cells
8) Confidence 0.69 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.63 Pain Relevance 0.15
Several studies investigating the role of the cannabinoid system in adult neurogenesis found that stimulation of CB1 seemed to either increase or decrease adult neurogenesis [21,23].
Positive_regulation (stimulation) of CB1 associated with cannabinoid and neurodegenerative disease
9) Confidence 0.69 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2898685 Disease Relevance 0.56 Pain Relevance 0.33
This finding suggested that in morphine dependence, upregulation of cannabinoid CB1 receptors occurred.
Positive_regulation (upregulation) of CB1 associated with addiction, cannabinoid and morphine
10) Confidence 0.67 Published 2001 Journal Brain Res. Section Abstract Doc Link 11478928 Disease Relevance 0.27 Pain Relevance 1.48
Upregulation of CB1 receptors and agonist-stimulated [35S]GTPgammaS binding in the prefrontal cortex of depressed suicide victims.
Positive_regulation (Upregulation) of CB1 in prefrontal associated with suicidal behaviour, analgesic and agonist
11) Confidence 0.67 Published 2004 Journal Mol. Psychiatry Section Title Doc Link 14966476 Disease Relevance 0.72 Pain Relevance 0.37
Whole cell voltage clamp recordings were performed to measure the effects of CB1R activation on excitatory synaptic responses evoked in the presence of the GABA-A antagonist picrotoxin (100 ┬ÁM) by stimulating layer 2/3 to layer 5/6 pyramidal cells synapses.
Positive_regulation (activation) of CB1R in pyramidal cells associated with gaba, pyramidal cell and antagonist
12) Confidence 0.66 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0 Pain Relevance 0.34
A recent study published by Hill et al [81] demonstrated that chronic administration of DMI does not modify endocannabinoid levels in the PFC, hippocampus, hypothalamus, or amygdala, but increases CB1 receptor density in the hippocampus and hypothalamus.
Neg (not) Positive_regulation (increases) of CB1 in hypothalamus associated with endocannabinoid, hippocampus and amygdala
13) Confidence 0.65 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 0.08 Pain Relevance 0.85
Activation of CB1 receptors localized on excitatory presynaptic boutons of prefrontal infralimbic cortical neurons making synapses with BNST excitatory projecting neurons to VTA, inhibits VTA dopamine neurons upon infralimbic cortical stimulation, suggesting a new neuronal circuitry for the actions of cannabinoids [14], [15].
Positive_regulation (Activation) of CB1 in dopamine neurons associated with dopamine and cannabinoid
14) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810340 Disease Relevance 0.45 Pain Relevance 0.38
Extracellular field recordings and whole cell patch clamp in the alBNST rat brain slice preparation revealed that activation of CB1 strongly inhibits excitatory and inhibitory synaptic transmission.


Positive_regulation (activation) of CB1 in brain
15) Confidence 0.65 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2810340 Disease Relevance 0 Pain Relevance 0.20
The authors further investigated whether pharmacologic augmentation of CB1 activation would lead to enhancements in extinction.
Spec (whether) Positive_regulation (activation) of CB1
16) Confidence 0.64 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906867 Disease Relevance 0.55 Pain Relevance 0.32
Interestingly, CB1 activation stimulates NPY release [28] therefore a positive feed-back loop between endocannabinoids and ghrelin-induced NPY would partly explain the lack of effect in CB1-KO animals.
Positive_regulation (activation) of CB1 associated with endocannabinoid
17) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0 Pain Relevance 0.38
CB1 is mainly localized to presynaptic axon terminals and activated by endocannabinoids synthesized and released by the postsynaptic neurons, a phenomenon otherwise known as retrograde signaling [12].
Positive_regulation (activated) of CB1 in neurons associated with endocannabinoid
18) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258435 Disease Relevance 0.16 Pain Relevance 0.29
It was observed that agonists of TRPV1 reduce bladder hyper-reactivity in MS (Fowler et al 1992) and have a modest antispastic effect in EAE mice, while a substantial effect was obtained with arvanil, a synthetic compound that can activate both CB1 and TRPV1 receptors (Melck et al 1999).
Positive_regulation (activate) of CB1 in bladder associated with multiple sclerosis and agonist
19) Confidence 0.62 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626929 Disease Relevance 1.14 Pain Relevance 0.51
There were no apparent changes in levels of CB1 receptor protein in midbrain regions, and there was an up-regulation of CB1 protein in the spinal cord.
Positive_regulation (up-regulation) of CB1 protein in spinal cord associated with cannabinoid, midbrain and spinal cord
20) Confidence 0.61 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11259535 Disease Relevance 0 Pain Relevance 1.60

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