INT6574

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Context Info
Confidence 0.59
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 35
Total Number 35
Disease Relevance 11.40
Pain Relevance 10.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pla2g1b) extracellular region (Pla2g1b)
Anatomy Link Frequency
nerve 3
paw 2
endothelium 2
platelet 2
macrophages 1
Pla2g1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 36 99.98 Very High Very High Very High
cINOD 21 99.76 Very High Very High Very High
Hyperalgesia 14 99.58 Very High Very High Very High
Morphine 7 99.48 Very High Very High Very High
epidural 5 99.48 Very High Very High Very High
bradykinin 19 99.32 Very High Very High Very High
Inflammation 107 99.08 Very High Very High Very High
tetrodotoxin 2 98.60 Very High Very High Very High
Paracetamol 4 98.48 Very High Very High Very High
Thermal hyperalgesia 4 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 42 99.72 Very High Very High Very High
Hyperalgesia 19 99.58 Very High Very High Very High
INFLAMMATION 135 99.44 Very High Very High Very High
Adhesions 2 99.44 Very High Very High Very High
Spinal Cord Injury 39 99.40 Very High Very High Very High
Neuropathic Pain 2 98.80 Very High Very High Very High
Hypersensitivity 2 98.64 Very High Very High Very High
Schizophrenia 36 98.16 Very High Very High Very High
Congenital Anomalies 2 96.64 Very High Very High Very High
Hypercalcemia 1 96.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quinacline, an inhibitor of phospholipase A2, inhibited the glycogenolytic nerve effects without any inhibition of the NE outflow.
Negative_regulation (inhibitor) of phospholipase A2 in nerve
1) Confidence 0.59 Published 1996 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 8946339 Disease Relevance 0 Pain Relevance 0.12
CONCLUSION: These results suggest that the behavioral pattern changes observed in the irritated nerve root model are caused in part by a high level of phospholipase A2 activity initiated by inflammation, and that the mechanism of action of epidural steroid injection in this model is inhibition of phospholipase A2 activity.


Negative_regulation (inhibition) of phospholipase A2 in nerve
2) Confidence 0.59 Published 1998 Journal Spine Section Body Doc Link 9636970 Disease Relevance 0 Pain Relevance 0
Additional pharmacologic studies showed that phospholipase A2 and nitric oxide are involved in the mechanisms that produce the mechanical and thermal hyperalgesia, respectively, N omega-nitro-L-arginine methyl ester and mepacrine are relatively selective inhibitors of nitric oxide synthase and phospholipase A2, respectively.
Negative_regulation (inhibitors) of phospholipase A2
3) Confidence 0.58 Published 1997 Journal Spine Section Body Doc Link 9160464 Disease Relevance 0.07 Pain Relevance 0
OBJECTIVES: To evaluate whether intervertebral disc material applied to the sciatic nerve produces hyperalgesia, and if the hyperalgesia in influenced by inhibitors of phospholipase A2 and nitric oxide synthase.
Negative_regulation (inhibitors) of phospholipase A2 in sciatic nerve
4) Confidence 0.58 Published 1997 Journal Spine Section Body Doc Link 9160464 Disease Relevance 0.09 Pain Relevance 0
Copper chelates of the non-steroidal anti-inflammatory drugs tested more strongly decreased the activity of soluble phospholipase A2 as compared to the ligands.
Negative_regulation (decreased) of phospholipase A2 associated with inflammation and cinod
5) Confidence 0.56 Published 1986 Journal Acta Physiol Pharmacol Bulg Section Abstract Doc Link 3751624 Disease Relevance 0.10 Pain Relevance 0.27
Ginkgetin, a biflavone isolated from Ginkgo biloba leaves, was previously reported as an inhibitor of group II phospholipase A2.
Negative_regulation (inhibitor) of phospholipase A2
6) Confidence 0.51 Published 1999 Journal Planta Med. Section Abstract Doc Link 10418340 Disease Relevance 0.34 Pain Relevance 0.28
Annexin I (lipocortin-1), a 37-kDa member of a family of phospholipid and calcium binding proteins, can mediate local anti-inflammatory effects of glucocorticoids via a mechanism that is partially dependent on inhibition of phospholipase A2 activity and adhesion and transmigration of polymorphonuclear leukocytes.
Negative_regulation (inhibition) of phospholipase A2 in polymorphonuclear leukocytes associated with inflammation and adhesions
7) Confidence 0.48 Published 1998 Journal J. Neurophysiol. Section Abstract Doc Link 9862910 Disease Relevance 0.39 Pain Relevance 0.55
[Antiphlogistic effectiveness of combinations of inhibitors of phospholipase A2, cyclooxygenase and lipoxygenases of the arachidonic acid cascade].
Negative_regulation (inhibitors) of phospholipase A2
8) Confidence 0.48 Published 1986 Journal Pharmazie Section Title Doc Link 3088612 Disease Relevance 0.42 Pain Relevance 0.35
PG I2 synthesis by rat aortic ring was inhibited by mepacrine, which inhibits phospholipase A2.
Negative_regulation (inhibits) of phospholipase A2
9) Confidence 0.45 Published 1986 Journal Jpn Heart J Section Abstract Doc Link 3553641 Disease Relevance 0.98 Pain Relevance 0.33
CONCLUSION: These results suggest that the behavioral pattern changes observed in the irritated nerve root model are caused in part by a high level of phospholipase A2 activity initiated by inflammation, and that the mechanism of action of epidural steroid injection in this model is inhibition of phospholipase A2 activity.


Negative_regulation (level) of phospholipase A2 in nerve
10) Confidence 0.43 Published 1998 Journal Spine Section Body Doc Link 9636970 Disease Relevance 0 Pain Relevance 0
Epidural injection of a selective inhibitor for phospholipase A2 resulted in the disappearance of hypersensitivity to noxious mechanical stimuli.
Negative_regulation (inhibitor) of phospholipase A2 associated with hypersensitivity and epidural
11) Confidence 0.42 Published 1998 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 9646768 Disease Relevance 0.76 Pain Relevance 0.96
Glucocorticoids inhibit phospholipase A2 (PLA2) by inducing in the target cells the synthesis of inhibitory proteins, the lipocortins, and consequently reduce the release of eicosanoids in a number of cells and tissues.
Negative_regulation (inhibit) of phospholipase A2
12) Confidence 0.40 Published 1986 Journal Agents Actions Section Abstract Doc Link 3532720 Disease Relevance 0.10 Pain Relevance 0.14
Quinacrine, a phospholipase A2 inhibitor, methylene blue, a guanylate cyclase inhibitor and tetraethylammonium, a potassium permeability inhibitor, inhibited carbachol-induced relaxation and augmented the magnitude of norepinephrine-induced contraction only when endothelium was present.
Negative_regulation (inhibitor) of phospholipase A2 in endothelium
13) Confidence 0.40 Published 1985 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3879308 Disease Relevance 0 Pain Relevance 0.37
The increase in Isc in the mucosa-submucosa preparation was inhibited by an inhibitor of phospholipase A2, quinacrine, and by indomethacin, tetrodotoxin or atropine; each of these compounds also abolished the second phase of the response.
Negative_regulation (inhibitor) of phospholipase A2 associated with tetrodotoxin
14) Confidence 0.40 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2110068 Disease Relevance 0 Pain Relevance 0.10
Furthermore, guanabenz did not inhibit platelet 12-lipoxygenase or phospholipase A2.
Negative_regulation (inhibit) of phospholipase A2 in platelet
15) Confidence 0.39 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3121363 Disease Relevance 0.73 Pain Relevance 0.25
We found that, in normal skin, bradykinin hyperalgesia is inhibited by the phospholipase A2 inhibitor, mepacrine, but not by the phospholipase C inhibitor, neomycin and is mimicked by phospholipase A2.
Negative_regulation (inhibitor) of phospholipase A2 in skin associated with hyperalgesia and bradykinin
16) Confidence 0.37 Published 1990 Journal Neuroscience Section Abstract Doc Link 2128375 Disease Relevance 0.46 Pain Relevance 0.77
Combinations of inhibitors of phospholipase A2, cyclooxygenase and lipoxygenase as the key enzymes of the arachidonic acid cascade were investigated with respect to their anti-inflammatory effectivity in the carrageenin paw edema and adjuvant arthritis of rats.
Negative_regulation (inhibitors) of phospholipase A2 in paw associated with pressure and volume under development, inflammation, experimental arthritis and arthritis
17) Confidence 0.36 Published 1986 Journal Pharmazie Section Abstract Doc Link 3088612 Disease Relevance 0.40 Pain Relevance 0.28
Rats surviving 6 weeks had a marked reduction of pancreatic wet weight and of pancreatic protein, amylase, phospholipase A2, and S-glucose as compared with healthy controls.
Negative_regulation (reduction) of phospholipase A2
18) Confidence 0.33 Published 1988 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 3387898 Disease Relevance 0.62 Pain Relevance 0.28
Chymopapain-induced reduction of proinflammatory phospholipase A2 activity and amelioration of neuropathic behavioral changes in an in vivo model of acute sciatica.
Negative_regulation (reduction) of phospholipase A2 associated with neuropathic pain and sciatica
19) Confidence 0.32 Published 1997 Journal J. Neurosurg. Section Title Doc Link 9171179 Disease Relevance 0.72 Pain Relevance 0.32
Effects of phospholipase A2 inhibitor, cyclooxygenase inhibitor and lipoxygenase inhibitor on glucagon secretion induced by the alpha 2-adrenergic agonist clonidine were studied in the isolated perfused rat pancreas.
Negative_regulation (inhibitor) of phospholipase A2 in pancreas associated with agonist and clonidine
20) Confidence 0.30 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.37

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