INT65744

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Context Info
Confidence 0.10
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.74
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) signal transduction (Map3k7) extracellular region (Il2)
plasma membrane (Map3k7) response to stress (Map3k7) cytoplasm (Map3k7)
Anatomy Link Frequency
lymphocytes 2
Map3k7 (Rattus norvegicus)
Il2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 1 94.76 High High
Inflammation 1 94.32 High High
rheumatoid arthritis 1 68.80 Quite High
cytokine 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1 94.32 High High
Hypersensitivity 2 92.56 High High
Arthritis 3 86.04 High High
Weight Loss 1 77.04 Quite High
Body Weight 1 76.84 Quite High
Pressure And Volume Under Development 1 76.04 Quite High
Rheumatoid Arthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that TAK-603 acts on the immune system, especially on cellular immunity. (2) In vitro: TAK-603 suppressed the mitogen-induced proliferation of mouse lymphocytes and the ConA-induced IFN-gamma and IL-2 production by rat lymphocytes at 10(-7) to 10(-5) M.
TAK-603 Negative_regulation (suppressed) of Gene_expression (production) of IL-2 in lymphocytes
1) Confidence 0.10 Published 1996 Journal Immunopharmacology Section Abstract Doc Link 8880222 Disease Relevance 0.74 Pain Relevance 0.18

General Comments

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