INT6575

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Context Info
Confidence 0.69
First Reported 1980
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 33
Total Number 37
Disease Relevance 3.48
Pain Relevance 13.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gcg) extracellular region (Gcg) cytoplasm (Gcg)
Anatomy Link Frequency
pancreas 12
plasma 2
blood 2
muscle 2
lateral hypothalamic area 2
Gcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 7 100.00 Very High Very High Very High
Clonidine 60 99.98 Very High Very High Very High
Morphine 11 99.98 Very High Very High Very High
Somatostatin 26 99.80 Very High Very High Very High
antagonist 31 99.74 Very High Very High Very High
tetrodotoxin 10 99.62 Very High Very High Very High
agonist 35 99.58 Very High Very High Very High
substance P 7 99.46 Very High Very High Very High
aspirin 24 99.22 Very High Very High Very High
conotoxin 15 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoglycemia 2 99.98 Very High Very High Very High
Diabetes Mellitus 22 98.72 Very High Very High Very High
Cancer 3 92.44 High High
INFLAMMATION 3 91.68 High High
Impaired Glucose Tolerance 7 85.16 High High
Malignant Neoplastic Disease 1 84.08 Quite High
Hypertrophy 1 82.40 Quite High
Hyperinsulinism 1 81.76 Quite High
Hyperglycemia 3 80.12 Quite High
Stress 3 78.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Infusion of clonidine (an alpha 2 agonist) caused significant increase of glucagon secretion even at a low dose of 0.5 nmol/kg/min, although infusion of neither an alpha 1 nor a beta 2 agonist caused it even at the high dose of 40.0 nmol/kg/min.
Positive_regulation (increase) of Localization (secretion) of glucagon associated with agonist and clonidine
1) Confidence 0.69 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1353630 Disease Relevance 0 Pain Relevance 0.29
Phentolamine (an alpha blocker) or yohimbine (an alpha 2 blocker) administration completely inhibited the increase of glucagon secretion caused by epinephrine infusion, but neither the administration of bunazosin (an alpha 1 blocker) nor beta blockers inhibited it.
Positive_regulation (increase) of Localization (secretion) of glucagon associated with beta blocker
2) Confidence 0.69 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1353630 Disease Relevance 0 Pain Relevance 0.26
Intravenous infusion of epinephrine alone (1 microgram/kg/min, equal to 0.7 nmol/kg/min) caused a significant increase in glucagon secretion.
Positive_regulation (increase) of Localization (secretion) of glucagon
3) Confidence 0.69 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1353630 Disease Relevance 0 Pain Relevance 0.24
Glucagon release induced by ventrolateral hypothalamic stimulation in the rat.
Positive_regulation (induced) of Localization (release) of Glucagon
4) Confidence 0.67 Published 1980 Journal Endocrinology Section Title Doc Link 6988208 Disease Relevance 0.20 Pain Relevance 0.13
Also, both 100 mumol/l acetylsalicylic acid (cyclooxygenase inhibitor) and 100 mumol/l caffeic acid (lipoxygenase inhibitor) significantly inhibited clonidine-induced glucagon secretion (P less than 0.01, respectively), whereas neither 10 mumol/l acetylsalicylic acid nor 10 mumol/l caffeic acid affected clonidine-induced glucagon secretion.
Positive_regulation (induced) of Localization (secretion) of glucagon associated with aspirin and clonidine
5) Confidence 0.62 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.60
The phospholipase A2 inhibitor mepacrine at 25 and 50 mumol/l significantly inhibited glucagon secretion induced by 0.1 mumol/l clonidine (P less than 0.01, respectively), whereas 5 mumol/l mepacrine did not affect clonidine-induced glucagon secretion.
Neg (not) Positive_regulation (induced) of Localization (secretion) of glucagon associated with clonidine
6) Confidence 0.62 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.58
Also, both 100 mumol/l acetylsalicylic acid (cyclooxygenase inhibitor) and 100 mumol/l caffeic acid (lipoxygenase inhibitor) significantly inhibited clonidine-induced glucagon secretion (P less than 0.01, respectively), whereas neither 10 mumol/l acetylsalicylic acid nor 10 mumol/l caffeic acid affected clonidine-induced glucagon secretion.
Positive_regulation (induced) of Localization (secretion) of glucagon associated with aspirin and clonidine
7) Confidence 0.62 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.58
The phospholipase A2 inhibitor mepacrine at 25 and 50 mumol/l significantly inhibited glucagon secretion induced by 0.1 mumol/l clonidine (P less than 0.01, respectively), whereas 5 mumol/l mepacrine did not affect clonidine-induced glucagon secretion.
Positive_regulation (induced) of Localization (secretion) of glucagon associated with clonidine
8) Confidence 0.62 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.56
The N-type Ca2+-channel blocker omega-conotoxin and the Na+-channel blocker tetrodotoxin inhibited glucose-induced glucagon release whereas tetraethylammonium, a blocker of delayed rectifying K+ channels, increased secretion.
Positive_regulation (induced) of Localization (release) of glucagon associated with tetrodotoxin and conotoxin
9) Confidence 0.54 Published 2005 Journal Endocrinology Section Abstract Doc Link 16081632 Disease Relevance 0 Pain Relevance 0.23
Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells.
Positive_regulation (stimulates) of Localization (release) of glucagon
10) Confidence 0.54 Published 2005 Journal Endocrinology Section Title Doc Link 16081632 Disease Relevance 0 Pain Relevance 0.18
In isolated rat pancreatic alpha-cells, glucose, arginine, and the sulfonylurea tolbutamide stimulated glucagon release.
Positive_regulation (stimulated) of Localization (release) of glucagon
11) Confidence 0.54 Published 2005 Journal Endocrinology Section Abstract Doc Link 16081632 Disease Relevance 0 Pain Relevance 0.10
These results suggest that even in a severely diabetic state, not only beta- but also also alpha 2-adrenergic agonism stimulates glucagon secretion from rat pancreatic alpha cells.
Positive_regulation (stimulates) of Localization (secretion) of glucagon in pancreatic alpha cells associated with diabetes mellitus
12) Confidence 0.54 Published 1993 Journal Metab. Clin. Exp. Section Abstract Doc Link 8102194 Disease Relevance 0.23 Pain Relevance 0.22
The alpha 2-adrenoceptor agonist clonidine at a concentration of 10(-7) mol/L significantly stimulated glucagon secretion as compared with basal levels in both normal (1,286 +/- 90 v 417 +/- 53 ng/L, P < .01) and STZ-D rats (551 +/- 86 v 130 +/- 19 ng/L, P < .01).
Positive_regulation (stimulated) of Localization (secretion) of glucagon associated with agonist and clonidine
13) Confidence 0.54 Published 1993 Journal Metab. Clin. Exp. Section Abstract Doc Link 8102194 Disease Relevance 0.17 Pain Relevance 0.25
Based on prior reports that sst2 tonically suppresses glucagon secretion, the antagonist most likely increased glucagon secretion from the pancreatic alpha-cells, with resultant increases in plasma glucose and then insulin.
Positive_regulation (increased) of Localization (secretion) of glucagon in plasma associated with antagonist
14) Confidence 0.49 Published 2002 Journal Endocrinology Section Abstract Doc Link 11897676 Disease Relevance 0 Pain Relevance 0.67
To study the influence on stimulated islet hormone secretion we infused arginine intravenously (7 mg/min) for 30 min, because arginine is known to stimulate the secretion of both insulin and glucagon.
Positive_regulation (stimulate) of Localization (secretion) of glucagon
15) Confidence 0.45 Published 1990 Journal Br J Surg Section Abstract Doc Link 2187562 Disease Relevance 0.44 Pain Relevance 0.08
Effects of phospholipase A2 inhibitor, cyclooxygenase inhibitor and lipoxygenase inhibitor on glucagon secretion induced by the alpha 2-adrenergic agonist clonidine were studied in the isolated perfused rat pancreas.
Positive_regulation (induced) of Localization (secretion) of glucagon in pancreas associated with agonist and clonidine
16) Confidence 0.45 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.43
Arachidonic acid metabolites and alpha 2-adrenoceptor-mediated glucagon secretion in rats.
Positive_regulation (2-adrenoceptor-mediated) of Localization (secretion) of glucagon associated with aspirin
17) Confidence 0.45 Published 1992 Journal Diabetes Res. Clin. Pract. Section Title Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.58
These results suggest that not only cyclooxygenase metabolites but also lipoxygenase metabolites are involved in the stimulation of glucagon secretion mediated through the alpha 2-adrenergic receptors in perfused rat pancreas.
Positive_regulation (mediated) of Localization (secretion) of glucagon in pancreas
18) Confidence 0.41 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.50
These results suggest that not only cyclooxygenase metabolites but also lipoxygenase metabolites are involved in the stimulation of glucagon secretion mediated through the alpha 2-adrenergic receptors in perfused rat pancreas.
Positive_regulation (stimulation) of Localization (secretion) of glucagon in pancreas
19) Confidence 0.41 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.50
Doses of 2 and 10 micrograms/kg of this analog completely suppressed the hypoglycemia-induced glucagon release.
Positive_regulation (induced) of Localization (release) of glucagon associated with hypoglycemia
20) Confidence 0.41 Published 1987 Journal Life Sci. Section Abstract Doc Link 2886886 Disease Relevance 0.19 Pain Relevance 0.24

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