INT6576

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Context Info
Confidence 0.71
First Reported 1984
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 1.49
Pain Relevance 7.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
aorta 1
brain 1
brainstem 1
pulmonary artery 1
dorsal horn 1
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 52 100.00 Very High Very High Very High
agonist 26 100.00 Very High Very High Very High
antagonist 12 100.00 Very High Very High Very High
opiate 3 99.80 Very High Very High Very High
medulla 1 99.68 Very High Very High Very High
Desipramine 6 99.48 Very High Very High Very High
aspirin 3 99.34 Very High Very High Very High
Hippocampus 5 98.68 Very High Very High Very High
cytokine 1 98.38 Very High Very High Very High
c fibre 3 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 2 99.90 Very High Very High Very High
Depression 1 95.94 Very High Very High Very High
Heart Rate Under Development 1 92.92 High High
Urological Neuroanatomy 2 89.12 High High
Hypoxia 1 79.76 Quite High
Hypertension 3 75.00 Quite High
Natriuresis 2 75.00 Quite High
Necrosis 2 75.00 Quite High
Nociception 2 75.00 Quite High
Cancer 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic DMI treatment attenuated the alpha 2-adrenoceptor-mediated inhibition of [3H]DA release, while the beta-adrenoceptor-mediated stimulation remained unchanged.
Localization (release) of alpha 2-adrenoceptor-mediated associated with desipramine
1) Confidence 0.71 Published 1985 Journal Brain Res. Section Abstract Doc Link 3995319 Disease Relevance 0 Pain Relevance 0.67
Direct splanchnic nerve stimulation (10 Hz, 5 min, bilaterally), or exogenous administration of the alpha-2-adrenoceptor agonist clonidine (15 micrograms h-1 kg-1), inhibited the secretion stimulated by PGE2, but not by VIP.
Localization (secretion) of alpha-2-adrenoceptor in PGE2 associated with agonist and clonidine
2) Confidence 0.68 Published 1994 Journal Acta Physiol. Scand. Section Abstract Doc Link 7942062 Disease Relevance 0 Pain Relevance 0.15
In addition, the location of alpha 2-adrenoceptor and opiate binding sites in consecutive sections of rat lumbar cord was investigated using in vitro autoradiography with selective ligands, and it was demonstrated that both opiate and alpha 2-receptor types are present within the same superficial layers of the dorsal horn of the same animal.
Spec (investigated) Localization (location) of alpha 2-adrenoceptor in dorsal horn associated with dorsal horn and opiate
3) Confidence 0.67 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3040431 Disease Relevance 0.07 Pain Relevance 1.50
Because decerebration did not alter the depression due to clonidine, and intraventricular (but not intrathecal) administration of oxymetazoline mimicked the effect of clonidine, the depressant effects of alpha 2-adrenergic agonists are mediated through alpha 2-adrenergic receptors localized in the brainstem.
Localization (localized) of alpha 2-adrenergic in brainstem associated with medulla, depression, agonist, intrathecal and clonidine
4) Confidence 0.62 Published 1985 Journal J. Neurosci. Section Abstract Doc Link 2861260 Disease Relevance 0.10 Pain Relevance 1.04
Alpha-2 adrenergic agonism stimulates islet glucagon release from perfused rat pancreas: possible involvement of alpha-2A adrenergic receptor subtype.
Localization (release) of alpha-2A in pancreas
5) Confidence 0.61 Published 1992 Journal Acta Endocrinol. Section Title Doc Link 1357904 Disease Relevance 0 Pain Relevance 0.33
Solubilization and characterization of rat brain alpha 2-adrenergic receptor.
Localization (Solubilization) of 2-adrenergic in brain
6) Confidence 0.57 Published 1985 Journal J. Neurochem. Section Title Doc Link 2985758 Disease Relevance 0 Pain Relevance 0.15
The mechanism related to NO release by alpha2-adrenoceptor agonist is impaired in SHRSP aorta.
Localization (release) of alpha2-adrenoceptor in aorta associated with agonist
7) Confidence 0.50 Published 1995 Journal Clin Exp Pharmacol Physiol Suppl Section Abstract Doc Link 9072330 Disease Relevance 0.36 Pain Relevance 0.42
The alpha 2-adrenergic agonist clonidine and the cytokine TNF alpha concentration-dependently inhibit [3H]-NE release; whereas, the alpha 2-adrenergic antagonist idazoxan potentiates [3H]-NE release.
Localization (release) of 2-adrenergic associated with antagonist, agonist, cytokine and clonidine
8) Confidence 0.47 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8862135 Disease Relevance 0.30 Pain Relevance 0.57
For the antagonists, the alpha 1/alpha 2-binding selectivity ratio most significantly correlated with the functional alpha 1/alpha 2-blocking selectivity ratios assessed in vitro (rabbit isolated pulmonary artery: antagonism of alpha 1-adrenoceptor-induced vasoconstriction and alpha 2-adrenoceptor-evoked facilitation of transmitter release) and in vivo (antagonism of alpha 1- and alpha 2-adrenoceptor-mediated vasoconstriction in pithed normotensive rats).
Localization (release) of alpha 2-adrenoceptor-evoked in pulmonary artery associated with antagonist and increased venous pressure under development
9) Confidence 0.47 Published 1984 Journal J. Med. Chem. Section Abstract Doc Link 6142954 Disease Relevance 0.26 Pain Relevance 0.51
Arachidonic acid metabolites and alpha 2-adrenoceptor-mediated glucagon secretion in rats.
Localization (secretion) of alpha 2-adrenoceptor-mediated associated with aspirin
10) Confidence 0.26 Published 1992 Journal Diabetes Res. Clin. Pract. Section Title Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.58
In conclusion, these results argue in favor of moxonidine acting primarily on imidazoline I1-receptors to release ANP, with both alpha2-adrenoceptor and imidazoline I1-receptors exerting inhibitory inter-relation.
Localization (release) of alpha2-adrenoceptor
11) Confidence 0.18 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16774751 Disease Relevance 0.17 Pain Relevance 0.32
In contrast, alpha2-adrenergic receptors were increased in cortex for both CLO and SCO, decreased in hypothalamus for CLO, and decreased in hippocampus for SCO (p<0.05 for each).
Localization (decreased) of alpha2-adrenergic in cortex associated with hippocampus and clonidine
12) Confidence 0.08 Published 2000 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 10775770 Disease Relevance 0.22 Pain Relevance 0.95

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