INT65772

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Context Info
Confidence 0.49
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 8.34
Pain Relevance 6.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
spinal cord 2
nerve 2
Bdkrb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 384 100.00 Very High Very High Very High
Spinal cord 98 100.00 Very High Very High Very High
bradykinin 94 100.00 Very High Very High Very High
agonist 48 100.00 Very High Very High Very High
Hyperalgesia 43 100.00 Very High Very High Very High
addiction 1 100.00 Very High Very High Very High
allodynia 111 99.98 Very High Very High Very High
intrathecal 57 99.98 Very High Very High Very High
Nerve growth factor 2 99.98 Very High Very High Very High
Painful diabetic neuropathy 3 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 221 100.00 Very High Very High Very High
Hyperalgesia 81 100.00 Very High Very High Very High
Neuropathic Pain 218 99.98 Very High Very High Very High
Stress 42 99.56 Very High Very High Very High
Nociception 26 99.28 Very High Very High Very High
Diabetic Neuropathy 7 98.52 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 94.32 High High
Hypersensitivity 4 93.52 High High
Nervous System Injury 12 92.44 High High
INFLAMMATION 43 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is hypothesised that activation of B1R increases oxidative stress (aortic O2•?)
Positive_regulation (increases) of Positive_regulation (activation) of B1R associated with stress and b1 receptor
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.21 Pain Relevance 0.74
In diabetic rats, the intrathecal stimulation of B1R with its native agonist (des-Arg9-BK, 9.6 nmol) induced a significant and transient enhancement of tactile allodynia at 10 min post-injection.
Positive_regulation (induced) of Positive_regulation (stimulation) of B1R associated with brush evoked pain, diabetes mellitus, b1 receptor, agonist, bradykinin and intrathecal
2) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.39 Pain Relevance 1.54
Recent studies highlighted a primary role for the inducible kinin B1 receptor (B1R) in mediation of nociception and diabetes-induced neuropathic pain [6,7].
Positive_regulation (role) of Positive_regulation (inducible) of B1R associated with nociception, diabetes mellitus, b1 receptor and neuropathic pain
3) Confidence 0.45 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.98 Pain Relevance 1.18
Allodynia induced by spinal cord B1R stimulation
Positive_regulation (induced) of Positive_regulation (stimulation) of B1R in spinal cord associated with allodynia, b1 receptor and spinal cord
4) Confidence 0.43 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 1.68 Pain Relevance 1.37
Characteristics of nerve growth factor induced hyperalgesia in adult rats: dependence on enhanced bradykinin-1 receptor activity but not neurokinin-1 receptor activation.
Positive_regulation (induced) of Positive_regulation (enhanced) of bradykinin-1 receptor in nerve associated with addiction, hyperalgesia, nerve growth factor and bradykinin
5) Confidence 0.34 Published 1996 Journal Pain Section Title Doc Link 8880860 Disease Relevance 0.70 Pain Relevance 0.93
Several neurovascular systems are activated in T1D, including the inducible bradykinin (BK) B1 receptor (BKB1-R) subtype.
Positive_regulation (activated) of Positive_regulation (inducible) of B1 receptor associated with diabetes mellitus, b1 receptor and bradykinin
6) Confidence 0.25 Published 2005 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 16141788 Disease Relevance 1.38 Pain Relevance 0.78

General Comments

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