INT6580

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Context Info
Confidence 0.59
First Reported 1982
Last Reported 2011
Negated 4
Speculated 13
Reported most in Abstract
Documents 929
Total Number 942
Disease Relevance 381.53
Pain Relevance 376.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ptgs1) aging (Ptgs1) Golgi apparatus (Ptgs1)
endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)
Anatomy Link Frequency
platelet 42
blood 11
spinal 9
leukocyte 9
paw 9
Ptgs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 2177 100.00 Very High Very High Very High
Inflammation 1053 100.00 Very High Very High Very High
aspirin 1025 100.00 Very High Very High Very High
Pain 393 100.00 Very High Very High Very High
Analgesic 390 100.00 Very High Very High Very High
diclofenac 316 100.00 Very High Very High Very High
COX-2 inhibitor 273 100.00 Very High Very High Very High
COX2 229 100.00 Very High Very High Very High
Paracetamol 174 100.00 Very High Very High Very High
cOX1 170 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1888 100.00 Very High Very High Very High
Cancer 168 100.00 Very High Very High Very High
Toxicity 121 100.00 Very High Very High Very High
Colon Cancer 105 100.00 Very High Very High Very High
Necrosis 40 100.00 Very High Very High Very High
Stress 108 99.96 Very High Very High Very High
Pollakiuria 6 99.96 Very High Very High Very High
Hyperalgesia 185 99.92 Very High Very High Very High
Increased Venous Pressure Under Development 88 99.92 Very High Very High Very High
Hypersensitivity 81 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observed peak concentrations in lymph of the investigated drugs are likely to produce different biological effects with regard to cyclooxygenase-1 inhibition.
Negative_regulation (inhibition) of cyclooxygenase-1 in lymph
1) Confidence 0.59 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8894512 Disease Relevance 0.14 Pain Relevance 0.14
Cyclooxygenase inhibition led to significant increases in single-nephron and whole-kidney filtration and flow in mid and late pregnant rats.
Negative_regulation (inhibition) of Cyclooxygenase in kidney
2) Confidence 0.59 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3111275 Disease Relevance 0.24 Pain Relevance 0.08
Unlike morphine, which reduces response to UCD by spinal and supraspinal mechanisms and whose action is blocked by estrogen, the cyclooxygenase inhibitor, ketorolac acts at an estrogen-independent, non spinal site.
Negative_regulation (inhibitor) of cyclooxygenase in spinal associated with acular and morphine
3) Confidence 0.59 Published 2003 Journal Pain Section Abstract Doc Link 14499426 Disease Relevance 0.11 Pain Relevance 1.18
Renal effects of cyclooxygenase inhibition in the pregnant rat.
Negative_regulation (inhibition) of cyclooxygenase
4) Confidence 0.59 Published 1987 Journal Am. J. Physiol. Section Title Doc Link 3111275 Disease Relevance 0.21 Pain Relevance 0.07
In the control periods, before cyclooxygenase inhibition, the male kidney was vasodilated relative to the female.
Negative_regulation (inhibition) of cyclooxygenase in kidney
5) Confidence 0.59 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3344806 Disease Relevance 0.10 Pain Relevance 0.09
Cyclooxygenase inhibition in the anesthetized intact female rat produced significant increases in single-nephron glomerular filtration rate, glomerular plasma flow rate, glomerular filtration rate, and renal plasma flow, whereas afferent and efferent arteriolar resistances and renal vascular resistance fell.
Negative_regulation (inhibition) of Cyclooxygenase in nephron
6) Confidence 0.59 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3344806 Disease Relevance 0.09 Pain Relevance 0.15
These data suggest a functional sex difference in both baseline renal hemodynamics and the renal response to cyclooxygenase inhibition, the latter unveiled by surgical stress.
Negative_regulation (inhibition) of cyclooxygenase associated with stress
7) Confidence 0.59 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3344806 Disease Relevance 0.16 Pain Relevance 0.14
BACKGROUND: Nonsteroidal antiinflammatory drugs (NSAIDs) suppress various hyperalgesia perhaps via inhibition of cyclooxygenase activity at the spinal cord.
Negative_regulation (inhibition) of cyclooxygenase in spinal cord associated with hyperalgesia, inflammation, cinod and spinal cord
8) Confidence 0.59 Published 1999 Journal Anesthesiology Section Abstract Doc Link 10422945 Disease Relevance 0.35 Pain Relevance 0.63
These beneficial effects could not be ascribed to NO donation and may reflect cyclooxygenase inhibition.
Negative_regulation (inhibition) of cyclooxygenase
9) Confidence 0.59 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9530274 Disease Relevance 0.37 Pain Relevance 0.26
Aminopyrine was less potent in its ability to inhibit cyclooxygenase activity.
Negative_regulation (inhibit) of cyclooxygenase
10) Confidence 0.59 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2498559 Disease Relevance 0 Pain Relevance 0.30
CONCLUSIONS: These studies allow dissociation of the contribution and consequences of uncoupling of mitochondrial oxidative phosphorylation and cyclooxygenase inhibition in the pathophysiology of NSAID enteropathy.
Negative_regulation (inhibition) of cyclooxygenase
11) Confidence 0.59 Published 2000 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10792129 Disease Relevance 0 Pain Relevance 0
METHODS: We compared key pathophysiologic events in the small bowel following (i) dinitrophenol, an uncoupling agent (ii) parenteral aspirin, to inhibit cyclooxygenase without causing a 'topical' effect and (iii) the two together, using (iv) indomethacin as a positive control.
Negative_regulation (inhibit) of cyclooxygenase in bowel
12) Confidence 0.59 Published 2000 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10792129 Disease Relevance 0 Pain Relevance 0
Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat.
Negative_regulation (inhibition) of cyclooxygenase associated with enteropathy and cinod
13) Confidence 0.59 Published 2000 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 10792129 Disease Relevance 0.10 Pain Relevance 0.20
The potency difference is similar to that for inhibition of cyclooxygenase in brain tissue and supports the hypothesis that cyclooxygenase products are involved in prolonged spinal nociceptive transmission.
Negative_regulation (inhibition) of cyclooxygenase in spinal associated with nociception and potency
14) Confidence 0.59 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8050472 Disease Relevance 0.10 Pain Relevance 0.34
Although the reasons for the discrepancy between this and the previous report are unclear, these results are consistent with previous studies that indicate an antinociceptive action of intrathecal alpha2-adrenergic agonists in the normal condition, a lack of such effect for cyclooxygenase inhibitors, and positive reinforcing effects of these two systems when co-stimulated.
Negative_regulation (inhibitors) of cyclooxygenase associated with agonist, antinociceptive and intrathecal
15) Confidence 0.59 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12505951 Disease Relevance 0 Pain Relevance 1.89
The results suggest that these effects are probably not mediated through an inhibition of cyclooxygenase, but a reduction in LTB4 levels induced by D-002 could explain these results.
Negative_regulation (inhibition) of cyclooxygenase
16) Confidence 0.59 Published 1998 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 9849648 Disease Relevance 0.69 Pain Relevance 0.35
Though BF-389 has been shown to be a potent inhibitor of cyclooxygenase, IC50 = 0.84 +/- 0.25 microM against the production of PGE2 in vitro, there is a great difference from most cyclooxygenase inhibitors; it also inhibits the 5-lipoxygenase enzyme.
Negative_regulation (inhibitor) of cyclooxygenase
17) Confidence 0.59 Published 1992 Journal Agents Actions Section Abstract Doc Link 1456184 Disease Relevance 0.56 Pain Relevance 0.45
Collectively these studies suggest that uncoupling may underlie the "topical" phase of NSAID damage which leads to increased intestinal permeability and inflammation, but concomitant inhibition of cyclooxygenase is essential to drive the inflammation to ulcers.
Negative_regulation (inhibition) of cyclooxygenase associated with inflammation, ulcers and cinod
18) Confidence 0.59 Published 1996 Journal Ital J Gastroenterol Section Abstract Doc Link 9032577 Disease Relevance 0.65 Pain Relevance 0.45
A number of studies show that the idea that inhibition of cyclooxygenase is the sole mechanism of NSAID-induced gastrointestinal damage is no longer tenable.
Negative_regulation (inhibition) of cyclooxygenase associated with cinod
19) Confidence 0.59 Published 1996 Journal Ital J Gastroenterol Section Abstract Doc Link 9032577 Disease Relevance 0 Pain Relevance 0.35
Relative importance and pathophysiological consequences of uncoupling and inhibition of cyclooxygenase were assessed following administration of R and S flurbiprofen: the former selectively uncouples whilst the latter is also an effective cyclooxygenase inhibitor.
Negative_regulation (inhibition) of cyclooxygenase
20) Confidence 0.59 Published 1996 Journal Ital J Gastroenterol Section Abstract Doc Link 9032577 Disease Relevance 0.27 Pain Relevance 0.42

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