INT65803

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Context Info
Confidence 0.32
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 1.24
Pain Relevance 8.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 3
spinal cord 2
Dh (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 588 100.00 Very High Very High Very High
spinal dorsal horn 350 100.00 Very High Very High Very High
Hippocampus 25 100.00 Very High Very High Very High
Dorsal horn 21 100.00 Very High Very High Very High
Spinal cord 219 99.90 Very High Very High Very High
c fibre 197 99.90 Very High Very High Very High
intrathecal 34 99.84 Very High Very High Very High
Pain 62 98.60 Very High Very High Very High
tetrodotoxin 10 97.98 Very High Very High Very High
projection neuron 21 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 59 98.60 Very High Very High Very High
Ganglion Cysts 27 95.84 Very High Very High Very High
Targeted Disruption 7 75.04 Quite High
Hypersensitivity 11 73.88 Quite High
Nociception 15 72.72 Quite High
Hyperalgesia 59 60.32 Quite High
INFLAMMATION 31 56.56 Quite High
Neuropathic Pain 21 55.20 Quite High
Peripheral Arterial Disease 7 54.64 Quite High
Nervous System Injury 7 38.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results also showed obvious differences in the HFS-induced c-Fos expression in mice and rats, 1) the peak expression of c-Fos in the mouse DH was detected at 3 h, whereas it was markedly increased in the DH of rats at 2 h [40]; and 2) the Fos-immunoreactive neurons were seen distributed across all of the mouse DH, while it distributed mainly in the superficial layers of rats DH [40] (and the present analysis, data not shown).


Gene_expression (expression) of DH in neurons associated with spinal dorsal horn
1) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.59
Changes in the field potential indicate alterations in the synaptic activity of the DH neurons.
Gene_expression (neurons) of DH in neurons associated with spinal dorsal horn
2) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.82
We also used immunohistochemical and immunofluorescence staining to measure expression of c-Fos in the DH following HFS in vivo.
Gene_expression (expression) of DH associated with spinal dorsal horn
3) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.25
Properties of LTP in the mouse DH in vivo
Gene_expression (Properties) of DH associated with spinal dorsal horn and long-term potentiation
4) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.72
In vivo Extracellular recordings of LTP in mice DH
Gene_expression (vivo) of DH associated with spinal dorsal horn and long-term potentiation
5) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0.33 Pain Relevance 0.67
LTP of synapses between primary afferent C-fibers and DH neurons has important functional roles in pain pathways [3].
Gene_expression (neurons) of DH in neurons associated with pain, c fibre, spinal dorsal horn and long-term potentiation
6) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0.27 Pain Relevance 1.54
In Experiment 1, on permanently cannulated animals, TTX (10 ng in 1.0 microliter saline) or saline (1.0 microliter) was injected uni- or bilaterally in the DH, respectively 1 h before PAR acquisition, immediately after PAR acquisition, and 1 h before PAR retrieval, always performed 48 h after the acquisition trial.
Gene_expression (acquisition) of DH associated with tetrodotoxin and hippocampus
7) Confidence 0.24 Published 1996 Journal Brain Res. Section Abstract Doc Link 8883885 Disease Relevance 0 Pain Relevance 0.76
In Experiment 1, on permanently cannulated animals, TTX (10 ng in 1.0 microliter saline) or saline (1.0 microliter) was injected uni- or bilaterally in the DH, respectively 1 h before PAR acquisition, immediately after PAR acquisition, and 1 h before PAR retrieval, always performed 48 h after the acquisition trial.
Gene_expression (acquisition) of DH associated with tetrodotoxin and hippocampus
8) Confidence 0.24 Published 1996 Journal Brain Res. Section Abstract Doc Link 8883885 Disease Relevance 0 Pain Relevance 0.75
HFS induced LTP within 5 min and lasts for 3–8 h during the period of recording and resulted in upregulation of p-CaMKII, p-ERK and p-CREB protein levels in the spinal cord and expression of c-Fos in DH.
Gene_expression (expression) of DH in spinal cord associated with spinal dorsal horn, long-term potentiation and spinal cord
9) Confidence 0.22 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2704201 Disease Relevance 0.06 Pain Relevance 1.14
From these studies, we have been able to demonstrate that TRPV1 is selectively expressed in the sensory nerve terminals at the DH of the spinal cord (laminae I and II) and CSTN.
Gene_expression (expressed) of DH in spinal cord associated with dorsal horn and spinal cord
10) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.57 Pain Relevance 0.83

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