INT6584

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Context Info
Confidence 0.39
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 31
Total Number 31
Disease Relevance 14.64
Pain Relevance 27.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) nucleus (Pax3) DNA binding (Pax3)
Anatomy Link Frequency
nerve 3
spinal 2
spinal cord 1
dorsal horn 1
neuronal 1
Pax3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 1223 100.00 Very High Very High Very High
Neuropeptide 73 100.00 Very High Very High Very High
spinal dorsal horn 10 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
c fibre 140 99.98 Very High Very High Very High
Inflammation 143 99.96 Very High Very High Very High
qutenza 413 99.88 Very High Very High Very High
calcitonin gene related peptide 32 99.80 Very High Very High Very High
Calcitonin gene-related peptide 18 99.80 Very High Very High Very High
antinociception 10 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 152 99.96 Very High Very High Very High
Nervous System Injury 72 99.82 Very High Very High Very High
Pressure And Volume Under Development 16 99.72 Very High Very High Very High
Nociception 205 99.60 Very High Very High Very High
Targeted Disruption 94 99.54 Very High Very High Very High
Injury 35 99.44 Very High Very High Very High
Reprotox - General 2 4 99.36 Very High Very High Very High
Pain 195 99.08 Very High Very High Very High
Depression 5 97.72 Very High Very High Very High
Neuropathic Pain 52 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was found that the acute topical application of RA (0.9 mg/mouse) or capsaicin (0.09 mg/mouse) significantly increased the mouse paw oedema induced by carrageenan, while an 8-day repeated topical treatment with the same doses of both compounds resulted in a marked inhibition of carrageenan-induced paw oedema matched by a reduction in SP tissue levels.
Negative_regulation (reduction) of SP in paw associated with pressure and volume under development, qutenza, rheumatoid arthritis and substance p
1) Confidence 0.39 Published 2000 Journal Mediators Inflamm Section Abstract Doc Link PMC1781768 Disease Relevance 1.65 Pain Relevance 0.93
'Knockout' (KO) mice completely lacking SP and neurokinin A due to a disruption of the preprotachykinin A gene and a matched population of wild-type (WT) mice had free access to two drinking bottles, one containing water and the other capsaicin at various concentrations.
Negative_regulation (lacking) of SP associated with targeted disruption, qutenza and substance p
2) Confidence 0.36 Published 2001 Journal Chem. Senses Section Abstract Doc Link 11418494 Disease Relevance 0.10 Pain Relevance 0.68
These data indicate that antinociception does not appear to depend on decreases in SP release or content as antinociception precedes decreases in SP release.
Negative_regulation (decreases) of SP associated with antinociception and substance p
3) Confidence 0.36 Published 1997 Journal Pain Section Abstract Doc Link 9231870 Disease Relevance 0.07 Pain Relevance 2.17
D-Substance P(1-7), which prevents antinociception, blocked capsaicin- and SP(1-7)-induced decreases in SP release, indicating that these effects are mediated by SP N-terminal activity.
Negative_regulation (decreases) of SP associated with antinociception, qutenza and substance p
4) Confidence 0.32 Published 1997 Journal Pain Section Abstract Doc Link 9231870 Disease Relevance 0.19 Pain Relevance 2.70
Furthermore, N/OFQ (1 nmol) administered i.pl. blocked SP (i.pl.)
Negative_regulation (blocked) of SP associated with substance p
5) Confidence 0.25 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10490918 Disease Relevance 0.73 Pain Relevance 1.22
These results indicate that tachyphylaxis of capsaicin-induced oedema is reversible and suggest that this response may be due mainly to a reduction of SP in sensory neurones but not to any loss of responsiveness of NK1 receptors.
Neg (not) Negative_regulation (reduction) of SP associated with pressure and volume under development, qutenza and substance p
6) Confidence 0.20 Published 1995 Journal Inflamm. Res. Section Abstract Doc Link 8597880 Disease Relevance 0.53 Pain Relevance 1.01
Strychnine, bicuculline, and 5-aminovaleric acid each inhibited desensitization to SP and NMDA, supporting the notion of recruitment of inhibitory transmitters in the attenuation of NMDA and SP activity.
Negative_regulation (desensitization) of SP associated with substance p
7) Confidence 0.16 Published 1991 Journal J. Neurosci. Section Abstract Doc Link 1719157 Disease Relevance 0 Pain Relevance 0.85
During development, the Pax-3 transcription factor (TF) maintains progenitor cells in an undifferentiated state whereas, during inflammation, Pax-3 was suppressed and genes involved in neuronal development (synapsin I) were up-regulated.
Negative_regulation (suppressed) of Pax-3 in neuronal associated with inflammation
8) Confidence 0.14 Published 2006 Journal BMC Physiol Section Abstract Doc Link PMC1382248 Disease Relevance 1.33 Pain Relevance 0.30
Consequently, our results in SPP-knockout mice can be attributed to a deficiency in either SP or neurokinin A or both.
Negative_regulation (deficiency) of SP associated with targeted disruption and substance p
9) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 0.65 Pain Relevance 0.74
Although the complexity of nociceptive transmission and modulation in the spinal cord make it difficult to address all questions in a single model, we believe the description of a SP-driven feed-forward inhibition to be a crucial finding towards the understanding of the role of SP in sensory transmission, modulation and plasticity.



Negative_regulation (inhibition) of SP in spinal cord associated with nociception, substance p and spinal cord
10) Confidence 0.12 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.16 Pain Relevance 0.83
SP, Enk, VIP, PHI, and BLIP levels were all decreased in the distal colon of piebald mice as compared to normal littermates, SP, BLIP, and Enk levels were also decreased in the dilated proximal colon of piebald mice.
Negative_regulation (decreased) of SP in proximal associated with enkephalin and substance p
11) Confidence 0.11 Published 1985 Journal J. Surg. Res. Section Abstract Doc Link 3990276 Disease Relevance 0.24 Pain Relevance 0.70
Behavioural responses induced by physalaemin (Phy), [pGlu6, L-Pro9]-SP (6-11) (septide), [pGlu6, D-Pro7]-SP (6-11) (D-septide) and eledoisin (Ele) were also dose-dependently decreased by relatively small doses of spantide.
Negative_regulation (decreased) of SP associated with substance p
12) Confidence 0.07 Published 1992 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1383832 Disease Relevance 0 Pain Relevance 0.70
Unexpectedly, however, SP was completely blocked by the administration of anti–IL-6R mAb (Fig. 3 C).
Negative_regulation (blocked) of SP
13) Confidence 0.06 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2373835 Disease Relevance 0.27 Pain Relevance 0.03
This response was resistant to blockers of classic vasodilators but inhibited in pharmacogenetic experiments that targeted blockade of the substance P (SP) and calcitonin gene-related peptide (CGRP) pathways.
Negative_regulation (blockade) of SP
14) Confidence 0.06 Published 2008 Journal Cardiovasc. Res. Section Body Doc Link 18203709 Disease Relevance 0.08 Pain Relevance 0
In experiments using these two tools, nerve injury-induced loss of SP (i.pl.)
Negative_regulation (loss) of SP in nerve associated with nervous system injury and substance p
15) Confidence 0.05 Published 2006 Journal Mol Pain Section Body Doc Link PMC1562366 Disease Relevance 1.10 Pain Relevance 1.33
Such a loss of type-1 C-fiber responses would be explained by the finding that spinal SP-immunoreactivity was markedly reduced in mice with injury (Fig. 1A).
Negative_regulation (reduced) of SP in spinal associated with c fibre, injury and substance p
16) Confidence 0.05 Published 2006 Journal Mol Pain Section Body Doc Link PMC1562366 Disease Relevance 1.12 Pain Relevance 1.10
The SP immunoreactivity in the lamina I and II of spinal dorsal horn was significantly reduced to approximately 50% of control by the nerve injury (Fig. 1C).
Negative_regulation (reduced) of SP in spinal associated with nervous system injury, spinal dorsal horn and substance p
17) Confidence 0.05 Published 2006 Journal Mol Pain Section Body Doc Link PMC1562366 Disease Relevance 0.59 Pain Relevance 0.40
As shown in Fig. 1A, a marked decrease in SP immunoreactivity in the ipsilateral superficial dorsal horn was observed at day 7 in nerve injured mice compared to sham operated controls, as previously reported[20].
Negative_regulation (decrease) of SP in dorsal horn associated with dorsal horn and substance p
18) Confidence 0.05 Published 2006 Journal Mol Pain Section Body Doc Link PMC1562366 Disease Relevance 0.48 Pain Relevance 0.39
Concomitantly with the inhibition of SP, anti–IL-6R mAb significantly inhibited the induction of CD8+ T cell–dependent autoimmune colitis.
Negative_regulation (inhibition) of SP in T cell associated with colitis
19) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2373835 Disease Relevance 0.26 Pain Relevance 0.04
NK1 receptor immunostaining was performed after behavioral tests to confirm the effective removal of NK1R-expressing lamina I neurons in SP-SAP treated animals.
Negative_regulation (removal) of SP in neurons associated with substance p
20) Confidence 0.05 Published 2005 Journal Mol Pain Section Body Doc Link PMC1185563 Disease Relevance 0 Pain Relevance 0.39

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