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Context Info
Confidence 0.53
First Reported 1996
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.23
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
platelet 2
Pltct1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 5 99.56 Very High Very High Very High
depression 2 98.00 Very High Very High Very High
Clonidine 1 92.60 High High
Catecholamine 1 87.36 High High
Analgesic 6 83.76 Quite High
Antinociceptive 1 75.00 Quite High
Desipramine 1 68.36 Quite High
noradrenaline 1 67.08 Quite High
fluoxetine 1 66.12 Quite High
Serotonin 1 64.88 Quite High
Disease Link Frequency Relevance Heat
Depression 2 98.00 Very High Very High Very High
INFLAMMATION 1 73.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The evaluation of platelet antiaggregating profile lead us to identify a new potent prototype of antiplatelet derivative, that is (6a) (IC(50)=2.3 microM), which acts in arachidonic acid pathway probably by inhibition of platelet COX-1 enzyme.
Negative_regulation (inhibition) of platelet COX-1 enzyme in platelet
1) Confidence 0.53 Published 2004 Journal Bioorg. Med. Chem. Section Abstract Doc Link 15158783 Disease Relevance 0.07 Pain Relevance 0.19
Because of the density of platelet I1 binding sites was downregulated by both of the antidepressants, we postulate that a decrease in platelet I1 binding site density may be related to an improved state from depression that these antidepressants produce.
Negative_regulation (decrease) of platelet I1 binding site in platelet associated with antidepressant and depression
2) Confidence 0.02 Published 1996 Journal J Psychiatr Res Section Abstract Doc Link 8884656 Disease Relevance 0.16 Pain Relevance 0.59

General Comments

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