INT65846

Context Info Confidence 0.53 First Reported 1996 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.23 Pain Relevance 0.78

Anatomy Link Frequency platelet 2 Pltct1 (Mus musculus)

Pain Link Frequency Relevance Heat antidepressant 5 99.56 depression 2 98.00 Clonidine 1 92.60 Catecholamine 1 87.36 Analgesic 6 83.76 Antinociceptive 1 75.00 Desipramine 1 68.36 noradrenaline 1 67.08 fluoxetine 1 66.12 Serotonin 1 64.88

Disease Link Frequency Relevance Heat Depression 2 98.00 INFLAMMATION 1 73.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The evaluation of platelet antiaggregating profile lead us to identify a new potent prototype of antiplatelet derivative, that is (6a) (IC(50)=2.3 microM), which acts in arachidonic acid pathway probably by inhibition of platelet COX-1 enzyme.

Negative_regulation (inhibition) of platelet COX-1 enzyme in platelet

1) Confidence 0.53 Published 2004 Journal Bioorg. Med. Chem. Section Abstract Doc Link 15158783 Disease Relevance 0.07 Pain Relevance 0.19

Because of the density of platelet I1 binding sites was downregulated by both of the antidepressants, we postulate that a decrease in platelet I1 binding site density may be related to an improved state from depression that these antidepressants produce.

Negative_regulation (decrease) of platelet I1 binding site in platelet associated with antidepressant and depression

2) Confidence 0.02 Published 1996 Journal J Psychiatr Res Section Abstract Doc Link 8884656 Disease Relevance 0.16 Pain Relevance 0.59

General Comments

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