INT6585

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Context Info
Confidence 0.52
First Reported 1986
Last Reported 2010
Negated 5
Speculated 6
Reported most in Abstract
Documents 110
Total Number 116
Disease Relevance 40.67
Pain Relevance 89.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Insrr)
Anatomy Link Frequency
nerve 8
spinal 4
spinal cord 4
neurons 4
knee joint 2
Insrr (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 297 100.00 Very High Very High Very High
opioid receptor 261 100.00 Very High Very High Very High
Cholecystokinin 114 100.00 Very High Very High Very High
nMDA receptor 108 100.00 Very High Very High Very High
Opioid 89 100.00 Very High Very High Very High
orphanin 80 100.00 Very High Very High Very High
gABA 58 100.00 Very High Very High Very High
Potency 37 100.00 Very High Very High Very High
dopamine receptor 29 100.00 Very High Very High Very High
Kappa opioid receptor 22 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 312 99.82 Very High Very High Very High
INFLAMMATION 146 99.64 Very High Very High Very High
Hyperalgesia 343 99.60 Very High Very High Very High
Nociception 192 99.56 Very High Very High Very High
Insulin Resistance 50 99.54 Very High Very High Very High
Neuropathic Pain 447 99.48 Very High Very High Very High
Pain 256 99.46 Very High Very High Very High
Apoptosis 77 99.44 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 37 99.08 Very High Very High Very High
Diabetes Mellitus 53 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that N. sativa oil and thymoquinone produce antinociceptive effects through indirect activation of the supraspinal mu(1)- and kappa-opioid receptor subtypes.
Positive_regulation (activation) of receptor associated with kappa opioid receptor and antinociceptive
1) Confidence 0.52 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10913589 Disease Relevance 0.11 Pain Relevance 0.74
The behavioral experiments suggest that NMDA receptor antagonists may suppress benzodiazepine withdrawal responses, while the biochemical study reveals upregulation of the NMDA receptor, which may play an important role in the hypersusceptibility to DMCM-induced seizure in diazepam-withdrawn mice.
Positive_regulation (upregulation) of receptor associated with nmda receptor antagonist, convulsion, nmda receptor and withdrawal
2) Confidence 0.30 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9550303 Disease Relevance 0.23 Pain Relevance 0.37
The results suggest that histamine H(1) and H(3) receptor activations increase sensitivity to nociceptive stimulus in the formalin test.
Positive_regulation (activations) of receptor associated with nociception
3) Confidence 0.22 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 16631358 Disease Relevance 0.55 Pain Relevance 0.70
Similar to big dynorphin and dynorphin A, NEM produced nociceptive behavior mediated through inhibition of the degradation of endogenous dynorphins, presumably big dynorphin that in turn activates the NMDA receptor ion-channel complex by acting on the polyamine recognition site.
Positive_regulation (activates) of receptor associated with nociception, dynorphin and nmda receptor
4) Confidence 0.20 Published 2009 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 19607971 Disease Relevance 0.40 Pain Relevance 0.66
Our principal finding was that big dynorphin was the most potent pronociceptive dynorphin; when administered intrathecally into mice at extremely low doses (1-10fmol), big dynorphin produced nociceptive behavior through the activation of the NMDA receptor ion-channel complex by acting on the polyamine recognition site.
Positive_regulation (activation) of receptor associated with nociception, dynorphin and nmda receptor
5) Confidence 0.20 Published 2009 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 19607971 Disease Relevance 0.41 Pain Relevance 0.68
Inhibition by intrathecal yohimbine of the mu (nondiabetic) and bicuculline of the delta response (diabetic) suggested spinal alpha2-adrenergic and GABA(A) receptor mediation, respectively, for the descending systems.
Positive_regulation (mediation) of receptor in spinal associated with gaba, diabetes mellitus and intrathecal
6) Confidence 0.19 Published 1998 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 9714077 Disease Relevance 0.53 Pain Relevance 0.68
Importance of CCK-A receptor for gallbladder contraction and pancreatic secretion: a study in CCK-A receptor knockout mice.
Positive_regulation (Importance) of receptor associated with targeted disruption
7) Confidence 0.16 Published 2001 Journal Jpn. J. Physiol. Section Title Doc Link 11734079 Disease Relevance 0.10 Pain Relevance 0.32
Half-maximal naloxone-induced receptor upregulation occurred after two days; receptor density was maximal at 5 days.
Positive_regulation (upregulation) of receptor associated with narcan
8) Confidence 0.16 Published 1986 Journal Brain Res. Section Abstract Doc Link 3006869 Disease Relevance 0.16 Pain Relevance 0.75
Taken together, these data definitively demonstrate that morphine tolerance development in mice is independent of opioid receptor sequence.
Neg (independent) Positive_regulation (independent) of receptor associated with tolerance, opioid receptor and morphine
9) Confidence 0.16 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11427338 Disease Relevance 0.27 Pain Relevance 0.78
Neuromedin C and acetylcholine increased amylase secretion in CCK-A receptor (-/-) mice similar to (+/-) and (+/+) mice.
Positive_regulation (increased) of receptor
10) Confidence 0.15 Published 2001 Journal Jpn. J. Physiol. Section Abstract Doc Link 11734079 Disease Relevance 0.07 Pain Relevance 0.31
Thus, the antinociception produced through activation of the delta-2 receptor in the brain by cold water swim stress involved a descending pathway mediated by spinal GABAA receptors.
Positive_regulation (activation) of receptor in brain associated with stress and antinociception
11) Confidence 0.15 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7636735 Disease Relevance 0.49 Pain Relevance 1.02
Therefore, it may be suggested that tramadol exerts a seizurogenic effect on mice via an H(1) receptor activation-linked pathway possibly through an opioid receptor-dependent release of histamine from the mast cells.
Spec (possibly) Positive_regulation (activation) of receptor in mast cells associated with tramadol and opioid receptor
12) Confidence 0.14 Published 2010 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 20012267 Disease Relevance 0.46 Pain Relevance 0.61
These results demonstrate that clozapine induction of c-fos messenger RNA is not dependent on the D3 dopamine receptor subtype in the striatum or nucleus accumbens.
Neg (not) Positive_regulation (dependent) of receptor in striatum associated with nucleus accumbens and dopamine receptor
13) Confidence 0.14 Published 1999 Journal Neuroscience Section Abstract Doc Link 10218801 Disease Relevance 0 Pain Relevance 0.53
These results suggest that the hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity induced by morphine may be modulated via the activation of the GABA(A) receptor induced by diazepam.
Positive_regulation (activation) of receptor associated with gaba, dopamine receptor, tolerance, attention deficit hyperactivity disorder and morphine
14) Confidence 0.12 Published 2001 Journal Pharmacol. Res. Section Abstract Doc Link 11735352 Disease Relevance 0.49 Pain Relevance 1.27
Synaptic inhibition could contribute to this process because spontaneous spike discharge in the SC was modulated by GABA(A) receptor activation at postnatal days (P) 1-3.
Positive_regulation (activation) of ) receptor in spike associated with gaba
15) Confidence 0.11 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11422449 Disease Relevance 0.07 Pain Relevance 0.27
Next we tested whether the PK11195-induced antinociception is attributable to reduced neurosteroid synthesis, which may possibly lead to reduced activation of the progesterone receptor and/or GABA(A) receptor.
Positive_regulation (activation) of ) receptor associated with antinociception and gaba
16) Confidence 0.10 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19403993 Disease Relevance 0.67 Pain Relevance 0.78
All these findings strongly suggest that herbicide atrazine exerts inflammatory activity through activation of putative G(q/11)-coupled neurosteroid receptor and phospholipase C.
Positive_regulation (activation) of neurosteroid receptor associated with inflammation
17) Confidence 0.10 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16381660 Disease Relevance 0.26 Pain Relevance 0.14
In agreement with pharmacological results, both 1a,b also had the highest receptor affinity and selectivity for the opioid mu receptor.
Positive_regulation (had) of receptor associated with opioid
18) Confidence 0.10 Published 1995 Journal J. Med. Chem. Section Abstract Doc Link 7658453 Disease Relevance 0 Pain Relevance 0.83
During a transient postnatal period, c-fos expression in a patchy distribution was induced by D1 receptor activation: only a faint response was detected on postnatal day 1, but islands of strong hybridization signals for c-fos mRNA in response to the D1 agonist were observed at postnatal day 3, with a progressive decrease in intensity from day 6 to day 15.
Positive_regulation (activation) of receptor associated with agonist
19) Confidence 0.09 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7637573 Disease Relevance 0 Pain Relevance 0.37
The c-fos response to D1 receptor activation in adults requires a previous sensitization of dopaminergic receptors by chronic treatment with reserpine or by lesion of the nigro-striatal pathway.
Positive_regulation (activation) of receptor
20) Confidence 0.09 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7637573 Disease Relevance 0 Pain Relevance 0.24

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