INT65855

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Context Info
Confidence 0.76
First Reported 1996
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 17.08
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
telomere 2
B-cell 1
nucleus 1
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 27 100.00 Very High Very High Very High
chemokine 10 100.00 Very High Very High Very High
Inflammation 55 96.48 Very High Very High Very High
Osteoarthritis 91 94.88 High High
cocaine 294 94.12 High High
Multiple sclerosis 1 92.60 High High
Chronic pancreatitis 3 80.80 Quite High
cINOD 21 78.32 Quite High
COX-2 inhibitor 54 57.44 Quite High
anesthesia 1 43.36 Quite Low
Disease Link Frequency Relevance Heat
Cancer 785 100.00 Very High Very High Very High
Microsatellite Instability 18 99.96 Very High Very High Very High
Apoptosis 214 99.84 Very High Very High Very High
Colon Cancer 106 99.84 Very High Very High Very High
Breast Cancer 339 99.68 Very High Very High Very High
Hypoxia 12 99.54 Very High Very High Very High
Papillomavirus Infection 55 98.90 Very High Very High Very High
Colorectal Cancer 97 98.36 Very High Very High Very High
Aging 67 97.56 Very High Very High Very High
Basal And Squamous Cell Skin Cancer 71 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conformational change and cellular accumulation, together with subsequent release of mutant and normal p53 protein from transformed cells, may initiate a B-cell response with generation of circulating autoantibodies to p53 protein (anti-p53).
Localization (release) of p53 in B-cell
1) Confidence 0.76 Published 1996 Journal Pancreas Section Abstract Doc Link 8884844 Disease Relevance 0.74 Pain Relevance 0.08
DNA damage and hypoxia resulted in increased p53 protein accumulation indicating that PDF expression may be controlled by cellular levels of p53.
Localization (accumulation) of p53 associated with hypoxia
2) Confidence 0.72 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19100681 Disease Relevance 0.87 Pain Relevance 0.23
Interpretation of immunohistochemical stains for COX-2, p53 and Ki-67
Localization (Interpretation) of p53
3) Confidence 0.68 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721998 Disease Relevance 0.15 Pain Relevance 0
Screening of the tumor related genes: PTEN, TP53 and SOX2
Localization (Screening) of TP53 associated with cancer
4) Confidence 0.65 Published 2010 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2991767 Disease Relevance 0.69 Pain Relevance 0
These ten miRNAs were chosen based on their high expression levels in tumors displaying p53 deletion, their relationship with p53 and their predicted target mRNAs (e.g. cytochrome C, ECIP-1, MAPPKKK1, TEM6, E2F5, GATA6, PP2B, and eIF5A).
Localization (relationship) of p53 associated with cancer
5) Confidence 0.62 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.96 Pain Relevance 0
Therefore, the relatively low mutation rate of p53 at early-stage limits the use in DNA-based detection of CRC.
Localization (rate) of p53 associated with colorectal cancer
6) Confidence 0.54 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.57 Pain Relevance 0
Among molecules regulating the p53 and RB tumor suppressor pathways, mutation of p53, overexpression of cyclin D1b, LMW cyclin E are apparently associated with poor clinical outcome of patients.
Localization (mutation) of p53 associated with cancer
7) Confidence 0.49 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.24 Pain Relevance 0.13
Among molecules regulating the p53 and RB tumor suppressor pathways, mutation of p53, overexpression of cyclin D1b, LMW cyclin E are apparently associated with poor clinical outcome of patients.
Localization (mutation) of p53 associated with cancer
8) Confidence 0.49 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.23 Pain Relevance 0.10
The HPV viral gene products E6 and E7 interact with host cell p53 and Rb proteins, resulting in p53 dysfunction and inactivation of Rb, respectively.
Localization (resulting) of p53 associated with papillomavirus infection
9) Confidence 0.37 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3003991 Disease Relevance 1.37 Pain Relevance 0
M for 7 d) cell proliferation inhibition has been suggested to be related to increased expression of p21, a major transcriptional target of p53, as well as down-regulation of nuclear antigen (PCNA), an essential DNA replication factor [11].
Localization (target) of p53
10) Confidence 0.29 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.31 Pain Relevance 0.39
The most widely studied tissue markers in CRC are thymidylate synthase, microsatellite instability, p53, K-ras and deleted in colorectal cancer (DCC), but they have not currently been recommended in routine practice for determining prognosis or predicting response to therapy [4].
Localization (deleted) of p53 associated with colon cancer and microsatellite instability
11) Confidence 0.28 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 0.94 Pain Relevance 0
(ER), progesterone receptor (PgR), proliferation marker (ki-67), tumor suppressor p53, regulator of apoptosis Bcl2, protooncogene cerbB2/HER2neu, epidermal growth factor receptor (EGFR) were assessed according to routine bio- and/or immunohistochemical methods.
Localization (regulator) of p53 associated with cancer and apoptosis
12) Confidence 0.26 Published 2005 Journal J Transl Med Section Body Doc Link PMC1201176 Disease Relevance 0.52 Pain Relevance 0
Indeed, in vitro treatment of chondrocytes with oxygen peroxide (H2O2) used as source of ROS, resulted in p53/p21Waf1/Cip1, p16ink4a accumulation and telomere attrition which are both hallmarks of cellular senescence [12, 28, 29].
Localization (accumulation) of p53 in telomere associated with aging
13) Confidence 0.19 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.42 Pain Relevance 0.28
Indeed, in vitro treatment of chondrocytes with oxygen peroxide (H2O2) used as source of ROS, resulted in p53/p21Waf1/Cip1, p16ink4a accumulation and telomere attrition which are both hallmarks of cellular senescence [12, 28, 29].
Localization (resulted) of p53 in telomere associated with aging
14) Confidence 0.19 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.42 Pain Relevance 0.28
Moreover, 14-3-3 protein, a transcriptional target of p53, leads to a sequestration of cdk2 in the cytoplasm [83].
Localization (target) of p53
15) Confidence 0.18 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.40 Pain Relevance 0.09
Treatment of p53-mutant breast cancer cells with 100 ?
Localization (Treatment) of p53 associated with breast cancer
16) Confidence 0.13 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 1.18 Pain Relevance 0
In addition to the release of damaging chemokines and cytokines, the tumor suppressor transcription factor, p53, has been shown to be necessary to induce apoptosis [21].
Localization (release) of p53 associated with chemokine, cancer, apoptosis and cytokine
17) Confidence 0.10 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 2.06 Pain Relevance 0.32
Acetylation of transcription factors can alter their ability to bind DNA (in the cases of E2F1, p53, EKLF, GATA1, and HNF-4), to interact with other proteins (c-Jun, TCF, ACTR, and HNF-4), or to remain in the nucleus (HNF-4).
Localization (cases) of p53 in nucleus
18) Confidence 0.04 Published 2002 Journal Genome Biol Section Body Doc Link PMC139359 Disease Relevance 0 Pain Relevance 0

General Comments

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