INT65856

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1996
Last Reported 2011
Negated 5
Speculated 2
Reported most in Abstract
Documents 138
Total Number 140
Disease Relevance 112.65
Pain Relevance 16.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
colon 3
telomere 3
thyroid 3
skin 2
nucleus 1
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 105 100.00 Very High Very High Very High
COX2 5 100.00 Very High Very High Very High
Inflammation 513 99.68 Very High Very High Very High
depression 120 99.64 Very High Very High Very High
Morphine 28 99.52 Very High Very High Very High
narcan 5 99.36 Very High Very High Very High
antagonist 105 99.30 Very High Very High Very High
Ventral tegmentum 102 99.20 Very High Very High Very High
qutenza 171 99.16 Very High Very High Very High
Kinase C 22 98.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 3772 100.00 Very High Very High Very High
Apoptosis 2262 100.00 Very High Very High Very High
Endometrial Cancer 661 100.00 Very High Very High Very High
Li-fraumeni Syndrome 153 100.00 Very High Very High Very High
Chronic Lymphoid Leukemia 144 100.00 Very High Very High Very High
Retinoblastoma 14 99.92 Very High Very High Very High
Basal Cell Carcinoma 32 99.84 Very High Very High Very High
Ovarian Cancer 154 99.74 Very High Very High Very High
Breast Cancer 931 99.72 Very High Very High Very High
INFLAMMATION 595 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The findings reported here indicate that gamma radiation activates the TP53 tumor suppressor, which then increases the expression of NAG1.
Positive_regulation (activates) of TP53 associated with cancer
1) Confidence 0.67 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.68 Pain Relevance 0.07
Instead, wild-type p53-bearing tumors cells could have mutated p53-downstream cascades, which consequently give resistance to p53-mediated cellular responses despite super-induction of p53.
Positive_regulation (induction) of p53 associated with cancer
2) Confidence 0.67 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761194 Disease Relevance 0.51 Pain Relevance 0
Expression of p53 restores an appropriate activation of the p53 downstream signaling in p53-mutated tumor cells probably because p53-mutated cells often have intact p53-downstream pathways.
Positive_regulation (activation) of p53 associated with cancer
3) Confidence 0.67 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761194 Disease Relevance 0.58 Pain Relevance 0
Here, we show that treatment of the human colon carcinoma cell line HCT116 with different concentrations of R-flurbiprofen leads to an accumulation of p53 protein which is accompanied by an increase in phosphorylated p53 at serine 15.
Positive_regulation (accumulation) of p53 in colon associated with colon cancer
4) Confidence 0.63 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15710360 Disease Relevance 0.67 Pain Relevance 0.12
Here, we show that treatment of the human colon carcinoma cell line HCT116 with different concentrations of R-flurbiprofen leads to an accumulation of p53 protein which is accompanied by an increase in phosphorylated p53 at serine 15.
Positive_regulation (increase) of p53 in colon associated with colon cancer
5) Confidence 0.63 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15710360 Disease Relevance 0.66 Pain Relevance 0.12
Immunohistochemistry of the resected specimen demonstrated that FUS homogeneously induced lethal and sublethal tumor damage with consecutive up-regulation of p53 and loss of proliferative activity.
Positive_regulation (up-regulation) of p53 associated with cancer
6) Confidence 0.62 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11731425 Disease Relevance 0.74 Pain Relevance 0.48
In p53 positive endometrioid endometrial carcinoma, p53 protein accumulation may be secondary to changes in its upstream regulatory proteins rather than the p53 gene itself.
Positive_regulation (accumulation) of p53 associated with endometrial cancer
7) Confidence 0.60 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.31 Pain Relevance 0
Our results show that prodigiosin triggers accumulation of the DNA-damage response tumor-suppressor protein p53 but that NAG-1 induction was independent of p53 accumulation.
Positive_regulation (accumulation) of p53 associated with cancer
8) Confidence 0.58 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17237295 Disease Relevance 0.67 Pain Relevance 0.09
Our results show that prodigiosin triggers accumulation of the DNA-damage response tumor-suppressor protein p53 but that NAG-1 induction was independent of p53 accumulation.
Positive_regulation (accumulation) of p53 associated with cancer
9) Confidence 0.58 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17237295 Disease Relevance 0.66 Pain Relevance 0.09
Our results demonstrate a novel mechanism of sulindac-induced apoptosis in human MM cells, namely, accumulation of p53, Bax, and Bak in mitochondria mediated by p38 MAPK activation downstream of ROS production.
Positive_regulation (accumulation) of p53 associated with multiple myeloma and apoptosis
10) Confidence 0.55 Published 2007 Journal Apoptosis Section Abstract Doc Link 17136320 Disease Relevance 1.14 Pain Relevance 0
Several mechanisms regulate the apoptotic process, such as induction of a p53-dependent-pathway after DNA-damaging agents, modulation by the bcl2 family of proteins, and activation of some effectors including the interleukin-converting enzyme (ICE) family of proteases and endonucleases [24,25].
Positive_regulation (induction) of p53 associated with apoptosis
11) Confidence 0.55 Published 2002 Journal BMC Cancer Section Body Doc Link PMC101407 Disease Relevance 0.45 Pain Relevance 0.05
Sporadic p53 protein accumulation without evident gene mutations was also apparent in both the carcinoma and squamous metaplastic lesions.
Positive_regulation (accumulation) of p53 protein associated with carcinoma
12) Confidence 0.54 Published 2002 Journal Pathol. Int. Section Abstract Doc Link 11972870 Disease Relevance 1.19 Pain Relevance 0.21
Pretreatment of the cells with 10nM morphine caused a transient, naloxone-reversible suppression of the appearance of activated p53 and the generation of DNA laddering.
Positive_regulation (activated) of p53 associated with narcan and morphine
13) Confidence 0.53 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12927789 Disease Relevance 0.84 Pain Relevance 0.88
In HCT-116 cells, DADS induced p53 and NAG-1 in a dose-dependent manner and the induction of p53 preceded that of NAG-1.
Positive_regulation (induction) of p53
14) Confidence 0.51 Published 2002 Journal J. Nutr. Section Abstract Doc Link 11925476 Disease Relevance 0.58 Pain Relevance 0.32
In HCT-116 cells, NAG-1 protein expression was increased 2.4-fold +/- 0.6 at 4.6 micromol/L and 6.1-fold +/- 1.7 at 23 micromol/L DADS, whereas p53 was induced 1.5-fold +/- 0.1 and 2.3-fold +/- 0.4.
Positive_regulation (induced) of p53
15) Confidence 0.51 Published 2002 Journal J. Nutr. Section Abstract Doc Link 11925476 Disease Relevance 0.55 Pain Relevance 0.30
DADS did not induce NAG-1 or p53 in p53 mutant cell lines; however, NAG-1 expression was induced by sulindac sulfide.
Neg (not) Positive_regulation (induce) of p53
16) Confidence 0.51 Published 2002 Journal J. Nutr. Section Abstract Doc Link 11925476 Disease Relevance 0.53 Pain Relevance 0.29
LOH could also be selected as the “second hit” for inactivating TP53 and CDKN2A.
Positive_regulation (inactivating) of TP53
17) Confidence 0.50 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808095 Disease Relevance 0.91 Pain Relevance 0
Sequencing of exon 5-8 of 10 selected BCCs further confirmed that melanocyte colonization of BCC is not dependent on wild-type p53.

2.

Neg (not) Positive_regulation (dependent) of p53 in melanocyte associated with basal cell carcinoma
18) Confidence 0.50 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989759 Disease Relevance 0.88 Pain Relevance 0
MMR mutant cells fail to activate a p73-dependent cell death activation pathway (41), which may explain the absence of a critical requirement for p53-mediated apoptosis (42).
Positive_regulation (requirement) of p53 associated with apoptosis and death
19) Confidence 0.49 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.75 Pain Relevance 0
Similar to HU210 injection, chronic THC injection also facilitated LFS-induced LTD in the VTA (74.1±4.6%, p<0.01 versus control, n?
Positive_regulation (facilitated) of LFS associated with ventral tegmentum, li-fraumeni syndrome and depression
20) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.94 Pain Relevance 1.00

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox