INT65883

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Context Info
Confidence 0.02
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CYP1A1, PPP4C) mitochondrion (CYP1A1) small molecule metabolic process (CYP1A1)
endoplasmic reticulum (CYP1A1) enzyme binding (CYP1A1) cell proliferation (CYP1A1)
CYP1A1 (Homo sapiens)
PPP4C (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 6 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, CYP1A catalyzes the formation of 3-OH-ropivacaine, the main metabolite formed in vivo, whereas the formation of 4-OH-ropivacaine, 2-OH-methyl-ropivacaine, and PPX was catalyzed by CYP3A.
CYP1A Binding (formation) of PPX
1) Confidence 0.02 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8886604 Disease Relevance 0 Pain Relevance 0.07
In conclusion, CYP1A catalyzes the formation of 3-OH-ropivacaine, the main metabolite formed in vivo, whereas the formation of 4-OH-ropivacaine, 2-OH-methyl-ropivacaine, and PPX was catalyzed by CYP3A.
CYP1A Binding (formation) of PPX
2) Confidence 0.02 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8886604 Disease Relevance 0 Pain Relevance 0.07

General Comments

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