INT65885

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Context Info
Confidence 0.18
First Reported 1996
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.64
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CYP1A1) mitochondrion (CYP1A1) small molecule metabolic process (CYP1A1)
oxidoreductase activity (CYP1A1) endoplasmic reticulum (CYP1A1) enzyme binding (CYP1A1)
Anatomy Link Frequency
liver 1
CYP1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 3 75.00 Quite High
antagonist 3 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Rheumatism 1 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 17 93.64 High High
Stress 30 92.84 High High
Apoptosis 30 88.88 High High
Cancer 7 86.40 High High
Breast Cancer 11 84.44 Quite High
Adverse Drug Reaction 1 62.40 Quite High
Hepatocellular Cancer 1 24.00 Low Low
Adenocarcinoma 3 5.00 Very Low Very Low Very Low
Metastasis 2 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of other genes, eg. induction of CYP1A1, IFNGR1 and WARS and downregulation of ER?
Negative_regulation (downregulation) of CYP1A1
1) Confidence 0.18 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.64 Pain Relevance 0
Incubation of ropivacaine and human liver microsomes in the presence of alpha-naphthoflavone or furafylline, inhibitors of CYP1A, decreased the formation of 3-OH-ropivacaine by about 85%, without affecting the formation of the other metabolites.
Negative_regulation (inhibitors) of CYP1A in liver
2) Confidence 0.04 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8886604 Disease Relevance 0 Pain Relevance 0.20

General Comments

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