INT65886

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Context Info
Confidence 0.40
First Reported 1996
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.08
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (PPP4C) nucleus (PPP4C) cytoplasm (PPP4C)
Anatomy Link Frequency
liver 1
PPP4C (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 97.12 Very High Very High Very High
Clonidine 2 95.92 Very High Very High Very High
lidocaine 2 92.88 High High
Versed 3 90.68 High High
Perioperative pain 1 81.80 Quite High
analgesia 1 78.16 Quite High
anesthesia 1 77.04 Quite High
local anesthetic 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Post Operative Pain 1 81.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of the interaction between PPX and premedications were examined using a human liver microsomal preparation in vitro.
PPX Binding (interaction) of in liver
1) Confidence 0.40 Published 2006 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 16445592 Disease Relevance 0.08 Pain Relevance 0.49
For each sample of hepatic microsomes, the correlation between the rate of PPX formation and the corresponding erythromycin N-demethylase activity was analyzed.
PPX Binding (formation) of
2) Confidence 0.18 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 10725304 Disease Relevance 0 Pain Relevance 0.16
The formation of 4-OH-ropivacaine, 2-OH-methyl-ropivacaine, and PPX was markedly inhibited in the presence of troleandomycin, an inhibitor of CYP3A.
PPX Binding (formation) of
3) Confidence 0.17 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8886604 Disease Relevance 0 Pain Relevance 0.18

General Comments

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