INT65889

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Context Info
Confidence 0.34
First Reported 1996
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 73
Total Number 73
Disease Relevance 60.98
Pain Relevance 38.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (RETNLB) extracellular region (RETNLB) molecular_function (RETNLB)
cellular_component (RETNLB)
Anatomy Link Frequency
neutrophils 5
cartilage 3
chondrocytes 2
macrophages 2
HDPF 2
RETNLB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1064 100.00 Very High Very High Very High
cytokine 454 100.00 Very High Very High Very High
Inflammatory mediators 100 100.00 Very High Very High Very High
chemokine 70 100.00 Very High Very High Very High
rheumatoid arthritis 8 100.00 Very High Very High Very High
cINOD 94 99.82 Very High Very High Very High
Morphine 18 99.72 Very High Very High Very High
Osteoarthritis 44 99.64 Very High Very High Very High
agonist 27 99.64 Very High Very High Very High
Cannabinoid receptor 36 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1508 100.00 Very High Very High Very High
Adhesions 13 100.00 Very High Very High Very High
Rheumatoid Arthritis 8 100.00 Very High Very High Very High
Acid Reflux 12 99.98 Very High Very High Very High
Disease 162 99.84 Very High Very High Very High
Nociception 2 99.72 Very High Very High Very High
Hyperglycemia 20 99.70 Very High Very High Very High
Atherosclerotic Plaque 11 99.68 Very High Very High Very High
Osteoarthritis 12 99.64 Very High Very High Very High
Cancer 66 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hallmark radiological feature of HD is the presence of a transition zone on a contrast enema (CETZ) [2].
Gene_expression (presence) of transition zone associated with disease
1) Confidence 0.34 Published 2007 Journal BMC Pediatr Section Body Doc Link PMC1790893 Disease Relevance 0.59 Pain Relevance 0
Although proliferation of lymphocytes tested in vitro after application of opiates in vivo is generally reduced, production of the pro-inflammatory cytokines and some functions of macrophages can be enhanced.
Gene_expression (production) of pro-inflammatory in macrophages associated with inflammation, opiate and cytokine
2) Confidence 0.31 Published 2003 Journal Cas. Lek. Cesk. Section Abstract Doc Link 12841129 Disease Relevance 0.41 Pain Relevance 1.22
Prior PC significantly reduced the post-ischemic increased expression of many inflammatory genes including cytokines, chemokines, adhesion molecules and pro-inflammatory transcription factors, and prevented the infiltration of neutrophils and macrophages in the ipsilateral cortex of rats subjected to focal ischemia.
Gene_expression (expression) of pro-inflammatory in cortex associated with chemokine, inflammation, ischemia, adhesions and cytokine
3) Confidence 0.29 Published 2006 Journal Neurochem. Int. Section Abstract Doc Link 16759752 Disease Relevance 1.25 Pain Relevance 0.74
Intra-articular corticosteroids may implement their anti-inflammatory effect by down-regulating genetic expression of several pro-inflammatory proteins.
Gene_expression (expression) of pro-inflammatory in articular associated with corticosteroid and inflammation
4) Confidence 0.29 Published 1996 Journal Drugs Section Abstract Doc Link 8891463 Disease Relevance 0.60 Pain Relevance 0.53
It is still a common practice to prescribe non-steroidal anti-inflammatory drugs (NSAIDs) which primarily work by inhibiting the production of pro-inflammatory prostaglandins.
Gene_expression (production) of pro-inflammatory associated with inflammation and cinod
5) Confidence 0.12 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2770552 Disease Relevance 1.30 Pain Relevance 0.95
Evidence suggests that exposure to bacterial endotoxin in early life can alter the production of pro-inflammatory cytokines in later life.
Gene_expression (production) of pro-inflammatory associated with inflammation and cytokine
6) Confidence 0.08 Published 2010 Journal Physiol. Behav. Section Abstract Doc Link 20184906 Disease Relevance 0.68 Pain Relevance 0.68
Improving the intestinal immunologic barrier function through spatial exclusion of other pathogenic microbial that could otherwise colonize the gut (43,44).Restoring normal intestinal permeability (45) in the face of inflammatory or allergic diseases by still ill-defined mechanisms that include cell wall and DNA components playing the role of immunomodulatory products (46) and by lowering the production of pro-inflammatory cytokines (47,48).Synthesizing vitamins (folic acid, biotin and other group B vitamins, vitamin K and so on) (116).
Gene_expression (production) of pro-inflammatory in face associated with inflammation, hypersensitivity, disease and cytokine
7) Confidence 0.07 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297498 Disease Relevance 0.61 Pain Relevance 0.19
Malarial disease pathogenesis is now generally associated with excessive production of pro-inflammatory cytokines , such as tumour necrosis factor.
Gene_expression (production) of pro-inflammatory associated with necrosis, inflammation, cancer, disease and cytokine
8) Confidence 0.06 Published 1998 Journal Ann Trop Med Parasitol Section Abstract Doc Link 9683899 Disease Relevance 2.24 Pain Relevance 0.26
Similarly, the relief of post-operative pain after abdominal surgery is also associated with a reduction in expression of pro-inflammatory mediators.
Gene_expression (expression) of pro-inflammatory associated with pain and inflammatory mediators
9) Confidence 0.05 Published 2007 Journal J Pharm Pharm Sci Section Abstract Doc Link 18261375 Disease Relevance 2.11 Pain Relevance 2.03
Interestingly, selective COX-2 inhibition (NS-398), but not selective COX-1 inhibition (SC-560), exerted a stimulatory effect on the expression of pro-inflammatory cytokines.
Gene_expression (expression) of pro-inflammatory associated with inflammation and cytokine
10) Confidence 0.05 Published 2004 Journal Scand. J. Immunol. Section Abstract Doc Link 15379866 Disease Relevance 0.77 Pain Relevance 1.15
The aim of the study was to characterize the in vitro effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the production of pro-inflammatory cytokines in a human whole blood assay.
Gene_expression (production) of pro-inflammatory in blood associated with inflammation, cinod and cytokine
11) Confidence 0.05 Published 2004 Journal Scand. J. Immunol. Section Abstract Doc Link 15379866 Disease Relevance 0.41 Pain Relevance 0.63
High doses of acetylsalicylic acid were needed to inhibit pro-inflammatory cytokine production.
Gene_expression (production) of pro-inflammatory associated with aspirin, inflammation and cytokine
12) Confidence 0.05 Published 2004 Journal Scand. J. Immunol. Section Abstract Doc Link 15379866 Disease Relevance 0.76 Pain Relevance 0.79
In contrast, low-to-moderate doses induced a modestly enhanced production of pro-inflammatory cytokines.
Gene_expression (production) of pro-inflammatory associated with inflammation and cytokine
13) Confidence 0.05 Published 2004 Journal Scand. J. Immunol. Section Abstract Doc Link 15379866 Disease Relevance 0.82 Pain Relevance 0.86
The present in vitro study shows the ability of AMA, used at concentrations between 10(-7) to 10(-5) M, to reduce the production of the pro-inflammatory cytokines, specifically interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha).
Gene_expression (production) of pro-inflammatory associated with necrosis, inflammation, cancer and cytokine
14) Confidence 0.04 Published 2009 Journal Pharmacol Rep Section Abstract Doc Link 20081246 Disease Relevance 1.00 Pain Relevance 0.83
Inhibitory effects of amantadine on the production of pro-inflammatory cytokines by stimulated in vitro human blood.
Gene_expression (production) of pro-inflammatory in blood associated with inflammation and cytokine
15) Confidence 0.04 Published 2009 Journal Pharmacol Rep Section Title Doc Link 20081246 Disease Relevance 0.90 Pain Relevance 0.89
For this reason, adipose tissue may represent an important site for the production of pro-inflammatory cytokines and acute phase reactants [3].
Gene_expression (production) of pro-inflammatory in adipose tissue associated with inflammation, obesity and cytokine
16) Confidence 0.03 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1183229 Disease Relevance 1.65 Pain Relevance 0.38
Meloxicam at submicromolar concentrations inhibited synovial PGE2 production but, up to therapeutic drug concentrations (< or = 4 microM), did not affect synovial production of the pro-inflammatory cytokine IL-1.
Gene_expression (production) of pro-inflammatory in PGE2 associated with inflammation and cytokine
17) Confidence 0.03 Published 1997 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 9364409 Disease Relevance 0.47 Pain Relevance 0.79
Some non-steroidal anti-inflammatory drugs (NSAIDs) can accelerate joint damage in osteoarthritis by enhancing the production of pro-inflammatory cytokines or inhibiting cartilage proteoglycan synthesis.
Gene_expression (production) of pro-inflammatory in cartilage associated with inflammation, cinod, osteoarthritis and cytokine
18) Confidence 0.03 Published 1997 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 9364409 Disease Relevance 0.36 Pain Relevance 0.66
The lower production of pro-inflammatory cytokines (IL-1, IL-6) in the pre-emptive group compared with the control group is beneficial, but its clinical importance remains to be determined.


Gene_expression (production) of pro-inflammatory
19) Confidence 0.03 Published 2004 Journal Acta Anaesthesiol Scand Section Body Doc Link 15196108 Disease Relevance 0 Pain Relevance 0
It is clear from this study that HA preparations can induce the synthesis of pro-inflammatory cytokines by monocytes.
Gene_expression (synthesis) of pro-inflammatory in monocytes associated with inflammation and cytokine
20) Confidence 0.03 Published 2001 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11341374 Disease Relevance 0.58 Pain Relevance 0.40

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