INT65898

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Context Info
Confidence 0.26
First Reported 1996
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.01
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ghsr) signal transducer activity (Ghsr)
Anatomy Link Frequency
pituitary stalk 2
Ghsr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 2 79.52 Quite High
Tetrahydrobiopterin 8 21.88 Low Low
diabetic neuropathy 8 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
potassium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 182 98.42 Very High Very High Very High
Growth Hormone Deficiency 8 93.60 High High
Stress 84 79.56 Quite High
Hypoglycemia 2 79.08 Quite High
Cardiovascular Disease 20 5.00 Very Low Very Low Very Low
Myocardial Infarction 18 5.00 Very Low Very Low Very Low
Hyperglycemia 16 5.00 Very Low Very Low Very Low
Diabetes Complications 12 5.00 Very Low Very Low Very Low
Diabetic Neuropathy 10 5.00 Very Low Very Low Very Low
Atherosclerosis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, we found an almost complete blockade of GH response to either GHRP-6 or GHRH plus GHRP-6 in patients with pituitary stalk transection, suggesting that this could be a cost-effective test for the diagnosis of this condition.
Negative_regulation (blockade) of GHRP-6 in pituitary stalk
1) Confidence 0.26 Published 1996 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 8887178 Disease Relevance 0.43 Pain Relevance 0.08
In contrast, we found an almost complete blockade of GH response to either GHRP-6 or GHRH plus GHRP-6 in patients with pituitary stalk transection, suggesting that this could be a cost-effective test for the diagnosis of this condition.
Negative_regulation (blockade) of GHRP-6 in pituitary stalk
2) Confidence 0.26 Published 1996 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 8887178 Disease Relevance 0.43 Pain Relevance 0.08
Mekinova et al. demonstrated that supplementation of streptozotocin (STZ) diabetic rats with vitamins C, E, and beta-carotene for 8 weeks produced a significant reduction of TBARS levels, GHS, and GHS-Px, an increase in Cu-SOD, and no change in catalase activity in kidneys [42].
Negative_regulation (reduction) of GHS associated with diabetes mellitus
3) Confidence 0.07 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1131912 Disease Relevance 0.57 Pain Relevance 0
Mekinova et al. demonstrated that supplementation of streptozotocin (STZ) diabetic rats with vitamins C, E, and beta-carotene for 8 weeks produced a significant reduction of TBARS levels, GHS, and GHS-Px, an increase in Cu-SOD, and no change in catalase activity in kidneys [42].
Negative_regulation (reduction) of GHS-Px associated with diabetes mellitus
4) Confidence 0.07 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1131912 Disease Relevance 0.58 Pain Relevance 0

General Comments

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