INT65907

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2011
Negated 4
Speculated 1
Reported most in Abstract
Documents 36
Total Number 37
Disease Relevance 19.50
Pain Relevance 20.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
nerve 13
sciatic nerve 6
bladder 5
urinary bladder 4
peripheral nerves 3
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 1606 100.00 Very High Very High Very High
Sciatic nerve 260 100.00 Very High Very High Very High
Spinal cord 33 100.00 Very High Very High Very High
qutenza 20 100.00 Very High Very High Very High
intrathecal 18 100.00 Very High Very High Very High
Hyperalgesia 12 100.00 Very High Very High Very High
substance P 9 100.00 Very High Very High Very High
neuralgia 6 100.00 Very High Very High Very High
Inflammation 44 99.86 Very High Very High Very High
Opioid 6 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 27 100.00 Very High Very High Very High
INFLAMMATION 46 99.86 Very High Very High Very High
Injury 328 99.84 Very High Very High Very High
Stress Incontinence 5 99.84 Very High Very High Very High
Polycystic Ovary Syndrome 128 99.68 Very High Very High Very High
Diabetes Mellitus 24 99.52 Very High Very High Very High
Pain 14 99.16 Very High Very High Very High
Hypertrophy 1 99.16 Very High Very High Very High
Nervous System Injury 144 99.00 Very High Very High Very High
Interstitial Cystitis 7 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study investigated the potential of intravesical instillation for localized reduction of NGF (nerve growth factor) expression in the urinary bladder.
Negative_regulation (reduction) of Gene_expression (expression) of NGF in urinary bladder associated with nerve growth factor
1) Confidence 0.59 Published 2006 Journal Mol. Pharm. Section Abstract Doc Link 16889433 Disease Relevance 0.28 Pain Relevance 0.17
Intravesical botulinum toxin A injections plus hydrodistension can reduce nerve growth factor production and control bladder pain in interstitial cystitis.
Negative_regulation (reduce) of in bladder Gene_expression (production) of nerve growth factor in nerve associated with pain, nerve growth factor and interstitial cystitis
2) Confidence 0.58 Published 2007 Journal Urology Section Title Doc Link 17905097 Disease Relevance 0.20 Pain Relevance 0.59
E2 downregulated both ERs in the bladder but not in the urethra, while NGF gene expression was downregulated in the urethra but unaffected by E2 in the bladder.
Negative_regulation (downregulated) of Gene_expression (expression) of NGF gene in bladder associated with stress incontinence
3) Confidence 0.56 Published 2004 Journal Endocrine Section Abstract Doc Link 15034193 Disease Relevance 0.49 Pain Relevance 0.17
However, at these doses, neither anti-inflammatory agent reduced the elevated levels of NGF.
Negative_regulation (reduced) of Gene_expression (levels) of NGF associated with nerve growth factor and inflammation
4) Confidence 0.43 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10653021 Disease Relevance 1.04 Pain Relevance 0.96
Beta adrenergic inhibition of capsaicin-induced, NK1 receptor-mediated nerve growth factor biosynthesis in rat skin.
Negative_regulation (inhibition) of Gene_expression (biosynthesis) of nerve growth factor in skin associated with nerve growth factor and qutenza
5) Confidence 0.43 Published 2004 Journal Pain Section Title Doc Link 15494187 Disease Relevance 0.27 Pain Relevance 1.27
Zinc reduces the hyperalgesia and upregulation of NGF and IL-1 beta produced by peripheral inflammation in the rat.
Negative_regulation (reduces) of Gene_expression (produced) of NGF associated with hyperalgesia and inflammation
6) Confidence 0.43 Published 1996 Journal Neuropharmacology Section Title Doc Link 8887968 Disease Relevance 0.77 Pain Relevance 0.80
The present study investigated the potential of intravesical instillation for localized reduction of NGF (nerve growth factor) expression in the urinary bladder.
Negative_regulation (reduction) of Gene_expression (expression) of nerve growth factor in urinary bladder associated with nerve growth factor
7) Confidence 0.43 Published 2006 Journal Mol. Pharm. Section Abstract Doc Link 16889433 Disease Relevance 0.28 Pain Relevance 0.17
The candidate antisense oligos were evaluated for their ability to reduce NGF expression in vitro by cotransfecting HEK293 cells with NGF cDNA.
Negative_regulation (reduce) of Gene_expression (expression) of NGF
8) Confidence 0.43 Published 2006 Journal Mol. Pharm. Section Abstract Doc Link 16889433 Disease Relevance 0.40 Pain Relevance 0.18
Capsaicin treatment of naive rats significantly reduced substance P in all tissues and NGF levels in the sciatic nerve.
Negative_regulation (reduced) of Gene_expression (levels) of NGF in sciatic nerve associated with nerve growth factor, qutenza, sciatic nerve and substance p
9) Confidence 0.43 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9259450 Disease Relevance 0.76 Pain Relevance 1.54
In neonatal rat atrial myocytes, HFES resulted in myocyte hypertrophy accompanied by an increase in NT-3 and a decrease in NGF expression.
Negative_regulation (decrease) of Gene_expression (expression) of NGF in myocytes associated with hypertrophy and nerve growth factor
10) Confidence 0.43 Published 2010 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 20138055 Disease Relevance 0.10 Pain Relevance 0.40
The most plausible explanation for this discrepancy is that the excessive concentrations of ovarian NGF protein might inhibit the expression of NGF mRNA in the ovaries.
Spec (might) Negative_regulation (inhibit) of Gene_expression (expression) of NGF mRNA in ovaries associated with nerve growth factor
11) Confidence 0.43 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC155675 Disease Relevance 0.46 Pain Relevance 0.70
[Relation of nerve growth factor expression with perineural invasion and pain in pancreatic cancer].
Negative_regulation ([Relation) of Gene_expression (expression) of nerve growth factor in nerve associated with pain, neuralgia, nerve growth factor and pancreatic cancer
12) Confidence 0.42 Published 2006 Journal Nan Fang Yi Ke Da Xue Xue Bao Section Title Doc Link 16939930 Disease Relevance 0.20 Pain Relevance 0.59
Since NGF and NT-3 CSF concentrations were also related to overall CSF protein levels in hydrocephalic children, some of the NGF and NT-3 molecules detected in CSF may actually be derived from neurotrophins circulating in the blood.
Negative_regulation (derived) of Gene_expression (detected) of NGF in blood associated with nerve growth factor
13) Confidence 0.42 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.62 Pain Relevance 0.72
At week 8, DCMAP in group of LBD-NGF was significantly restored compared with groups of NAT-NGF and the control (n?
Negative_regulation (restored) of Gene_expression (groups) of NAT-NGF associated with nerve growth factor
14) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.62 Pain Relevance 0.81
At day 0 after injury, there was no difference among the groups of the control, NAT-NGF, and LBD-NGF (n?
Neg (no) Negative_regulation (was) of Gene_expression (groups) of NAT-NGF associated with nerve growth factor and injury
15) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.55 Pain Relevance 1.08
Engineering and preparation of NGF
Negative_regulation (preparation) of Gene_expression (Engineering) of NGF associated with nerve growth factor
16) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.51 Pain Relevance 0.57
At week 12 after injury, there were significant differences among the groups of the control, NAT-NGF and LBD-NGF (n?
Negative_regulation (were) of Gene_expression (groups) of LBD-NGF associated with nerve growth factor and injury
17) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.57 Pain Relevance 0.84
At week 12 after injury, there were significant differences among the groups of the control, NAT-NGF and LBD-NGF (n?
Negative_regulation (were) of Gene_expression (groups) of NAT-NGF associated with nerve growth factor and injury
18) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.57 Pain Relevance 0.84
However, the levels of peripherin, NGF isoforms and TrkA in skin, peripheral nerves and DRG, respectively, were not significantly reduced in aged rats.
Neg (not) Negative_regulation (reduced) of Gene_expression (levels) of NGF in peripheral nerves
19) Confidence 0.42 Published 2010 Journal Neurobiol. Aging Section Abstract Doc Link 18499304 Disease Relevance 0.32 Pain Relevance 0
Subcutaneous injection of nerve growth factor (NGF) decreased the levels of fast retrograde axonal transport of activated ATF2 by 97% (p < 0.05) and elevated levels of retrograde axonal transport of total ATF2 by twofold (p < 0.02).
Negative_regulation (decreased) of Gene_expression (injection) of NGF in nerve associated with nerve growth factor
20) Confidence 0.42 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10479717 Disease Relevance 0.26 Pain Relevance 0.41

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