INT65914

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Context Info
Confidence 0.04
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 10
Disease Relevance 1.13
Pain Relevance 5.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gnptab) nucleus (Gnptab) transcription factor binding (Gnptab)
Anatomy Link Frequency
respiratory bronchioles 1
neurons 1
alveolar macrophages 1
brain 1
alveolar walls 1
Gnptab (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 4 100.00 Very High Very High Very High
substance P 28 99.68 Very High Very High Very High
c fibre 28 99.44 Very High Very High Very High
Neuropeptide 13 99.36 Very High Very High Very High
Glutamate receptor 6 98.68 Very High Very High Very High
Neurotransmitter 8 98.64 Very High Very High Very High
sodium channel 8 94.32 High High
Root ganglion neuron 2 94.20 High High
Enkephalin 3 85.72 High High
tetrodotoxin 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Deafness 8 96.36 Very High Very High Very High
Bordatella Infection 1 95.56 Very High Very High Very High
Ganglion Cysts 2 93.88 High High
Nicotine Addiction 4 62.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heterologous expression of transducin, a known chelator of G-protein betagamma subunits, almost completely abolished the neurotransmitter-induced current inhibition.
Gene_expression (expression) of subunits associated with neurotransmitter
1) Confidence 0.04 Published 1999 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10323308 Disease Relevance 0.10 Pain Relevance 0.42
Expression of genes for GABA-A receptor subunits beta2, beta3, and gamma2, plus ionotropic glutamate receptor subunits AMPA 2, AMPA 3, and kainate 2, increased at all three times.
Gene_expression (Expression) of receptor subunits beta2 associated with gaba and glutamate receptor
2) Confidence 0.03 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15934929 Disease Relevance 0.35 Pain Relevance 0.38
Expression of genes for GABA-A receptor subunits beta2, beta3, and gamma2, plus ionotropic glutamate receptor subunits AMPA 2, AMPA 3, and kainate 2, increased at all three times.
Gene_expression (Expression) of receptor subunits beta2 associated with gaba and glutamate receptor
3) Confidence 0.02 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15934929 Disease Relevance 0.35 Pain Relevance 0.38
None of the nAChR subunits studied was expressed by the SP-IR C-fibers.
Gene_expression (expressed) of subunits associated with c fibre and substance p
4) Confidence 0.02 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19115400 Disease Relevance 0.05 Pain Relevance 0.99
Alpha2, alpha3, alpha4, alpha5, alpha7, and beta2 subunits were detected at all levels of the intrapulmonary airways; including bronchi, terminal and respiratory bronchioles, alveolar walls, and alveolar macrophages.
Gene_expression (detected) of subunits in alveolar macrophages
5) Confidence 0.02 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19115400 Disease Relevance 0.06 Pain Relevance 0.95
The role of the beta 1 subunit in modulating ligand interactions at these channels was examined using a cell line stably expressing human beta1 and rat brain IIA alpha subunits.
Gene_expression (expressing) of subunits in brain
6) Confidence 0.01 Published 1996 Journal Neuropharmacology Section Abstract Doc Link 8887969 Disease Relevance 0 Pain Relevance 0.24
Here, we have identified a TTX-resistant Na(+) current (TTX-R I(Na)) in duodenum myenteric neurons of guinea pig and rat and have sought evidence regarding the molecular identity of the channel producing this current from the expression of Na(+) channel alpha subunits and the biophysical and pharmacological properties of TTX-R I(Na).
Gene_expression (expression) of subunits in neurons
7) Confidence 0.01 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12684457 Disease Relevance 0 Pain Relevance 0.07
Consistent with this, reverse transcription-PCR, single-cell profiling, and immunostaining experiments indicated that Na(V)1.9 transcripts and subunits, but not Na(V)1.8, were expressed in the enteric nervous system and restricted to myenteric sensory neurons.
Gene_expression (expressed) of subunits in enteric nervous system
8) Confidence 0.01 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12684457 Disease Relevance 0.09 Pain Relevance 0.12
Alpha2, alpha3, alpha4, alpha5, alpha7, and beta2 subunits were detected at all levels of the intrapulmonary airways; including bronchi, terminal and respiratory bronchioles, alveolar walls, and alveolar macrophages.
Gene_expression (detected) of subunits in alveolar walls
9) Confidence 0.01 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19115400 Disease Relevance 0.06 Pain Relevance 0.95
Alpha2, alpha3, alpha4, alpha5, alpha7, and beta2 subunits were detected at all levels of the intrapulmonary airways; including bronchi, terminal and respiratory bronchioles, alveolar walls, and alveolar macrophages.
Gene_expression (detected) of subunits in respiratory bronchioles
10) Confidence 0.01 Published 2009 Journal J. Neurosci. Res. Section Abstract Doc Link 19115400 Disease Relevance 0.06 Pain Relevance 0.95

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