INT65916

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Context Info
Confidence 0.55
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 3.09
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LAMB1) extracellular region (LAMB1) cell adhesion (LAMB1)
structural molecule activity (LAMB1) enzyme binding (LAMB1)
Anatomy Link Frequency
mesenchyme 1
embryonic kidney 1
LAMB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 48 100.00 Very High Very High Very High
sodium channel 43 100.00 Very High Very High Very High
local anesthetic 8 95.36 Very High Very High Very High
Neuropathic pain 2 93.64 High High
Pain 3 88.16 High High
tetrodotoxin 2 86.64 High High
Root ganglion neuron 5 82.16 Quite High
Central nervous system 1 76.32 Quite High
imagery 1 72.16 Quite High
metalloproteinase 12 62.88 Quite High
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 186 99.64 Very High Very High Very High
Neuropathic Pain 2 93.64 High High
Cancer 128 90.20 High High
Pain 2 88.16 High High
Ganglion Cysts 5 81.76 Quite High
Affective Disorder 3 74.72 Quite High
Depression 21 73.84 Quite High
Epilepsy 1 72.72 Quite High
Attention Deficit And Disruptive Behavior Disorders 4 70.40 Quite High
Convulsion 2 69.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Real time PCR data showed detectable gene expression (cycle threshold -Ct- below 34/35 cycles) for BDNF, BMP2, FGF2, GPI, L1CAM, Laminin B1 (LAMB1), Meteorin, Midkine, NR-CAM, and TGF?
Gene_expression (expression) of Laminin B1 associated with bdmf
1) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0.13
Real time PCR data showed detectable gene expression (cycle threshold -Ct- below 34/35 cycles) for BDNF, BMP2, FGF2, GPI, L1CAM, Laminin B1 (LAMB1), Meteorin, Midkine, NR-CAM, and TGF?
Gene_expression (expression) of LAMB1 associated with bdmf
2) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0.13
Real time PCR analysis also indicated the expression of GDNF, L1-CAM or LAMB1, but we could not sequence their PCR products, lacking the necessary identity confirmation.
Gene_expression (expression) of LAMB1
3) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0.12 Pain Relevance 0.03
Only morphogen BMP2 appeared overexpressed in mesenchyme, whereas GPI, LAMB1, Meteorin and TGF?
Gene_expression (overexpressed) of LAMB1 in mesenchyme
4) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0.08
Whereas in membranes of cells coexpressing the beta 1 subunit, the neurotoxins increased [3H]BTX binding 30-fold and the potencies of the sodium channel inhibitors closely matched those found at native sodium channels.
Gene_expression (coexpressing) of beta 1 subunit associated with sodium channel
5) Confidence 0.18 Published 1996 Journal Neuropharmacology Section Abstract Doc Link 8887969 Disease Relevance 0 Pain Relevance 0.50
By contrast, coexpression of the beta 1 subunit had dramatic effects on ligand interactions in isolated membranes.
Gene_expression (coexpression) of beta 1 subunit
6) Confidence 0.16 Published 1996 Journal Neuropharmacology Section Abstract Doc Link 8887969 Disease Relevance 0 Pain Relevance 0.44
Coexpression of the beta 1 subunit had no effect on the potencies of sodium channel blockers in inhibiting whole cell [3H]batrachotoxinin A benzoate ([3H]BTX) binding or veratridine-stimulated [14C]guanidinium influx.
Gene_expression (Coexpression) of beta 1 subunit associated with sodium channel
7) Confidence 0.16 Published 1996 Journal Neuropharmacology Section Abstract Doc Link 8887969 Disease Relevance 0 Pain Relevance 0.30
Coexpression of the beta 1 subunit also had no effect on the potencies of alpha scorpion toxin, brevetoxin, or RU 39568 in stimulating [14C]guanidinium influx.
Gene_expression (Coexpression) of beta 1 subunit
8) Confidence 0.16 Published 1996 Journal Neuropharmacology Section Abstract Doc Link 8887969 Disease Relevance 0 Pain Relevance 0.34
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (expression) of laminin B1
9) Confidence 0.09 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.50 Pain Relevance 0.03
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (underexpression) of laminin B1
10) Confidence 0.09 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.51 Pain Relevance 0.03
In following sections we describe several gene set approaches for testing the null hypothesis H0SC (expression levels of all genes in a gene set are not associated with the phenotype) that use p-values from separate tests of association of the phenotype with the expression of each gene in the gene set.
Gene_expression (expression) of associated with the phenotype
11) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941449 Disease Relevance 0 Pain Relevance 0
The null hypothesis of self-contained gene set methods is HoSC: Gene expression levels of all genes in S are NOT associated with the phenotype, while the null hypothesis for competitive methods is HoC: Genes in S are associated with the phenotype as much as genes in SC.
Gene_expression (expression) of associated with the phenotype
12) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941449 Disease Relevance 0 Pain Relevance 0
1, 2, …, m (Hoi: expression measured by ith probe is not associated with the phenotype).
Gene_expression (expression) of associated with the phenotype
13) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941449 Disease Relevance 0 Pain Relevance 0
The simulation scenarios varied according to: number of genes in a gene set, number of genes associated with the phenotype, effect sizes, correlation between expression of genes within a gene set, and the sample size.
Gene_expression (expression) of associated with the phenotype
14) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941449 Disease Relevance 0 Pain Relevance 0
Narrow Phenotype children were largely synonymous with strictly defined BP-I patients.
Gene_expression (synonymous) of Phenotype associated with manic depressive disorder
15) Confidence 0.03 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC2846895 Disease Relevance 1.54 Pain Relevance 0
To facilitate the identification of NaV1.8-specific inhibitors, we stably expressed the human NaV1.8 channel together with the auxiliary human beta1 subunit (NaV beta1) in human embryonic kidney 293 cells.
Gene_expression (expressed) of beta1 subunit in embryonic kidney associated with sodium channel
16) Confidence 0.03 Published 2006 Journal Assay Drug Dev Technol Section Abstract Doc Link 16506887 Disease Relevance 0.41 Pain Relevance 1.06

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