INT65919

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 6.47
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptch1) extracellular region (Ptch1) plasma membrane (Ptch1)
Anatomy Link Frequency
cornea 3
liver 1
Ptch1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 33 99.16 Very High Very High Very High
Pain 10 93.84 High High
Bioavailability 1 78.28 Quite High
ischemia 1 77.36 Quite High
nMDA receptor 2 75.00 Quite High
antagonist 2 75.00 Quite High
Analgesic 1 58.64 Quite High
Neuropathic pain 1 54.56 Quite High
Inflammation 10 48.40 Quite Low
Hyperalgesia 1 47.36 Quite Low
Disease Link Frequency Relevance Heat
Convulsion 4 100.00 Very High Very High Very High
Shock 276 99.98 Very High Very High Very High
Cancer 65 99.96 Very High Very High Very High
Skin Cancer 10 99.12 Very High Very High Very High
Hyperinsulinism 3 98.66 Very High Very High Very High
Hypoxia 5 97.84 Very High Very High Very High
Synovial Chondromatosis 8 97.64 Very High Very High Very High
Retinal Neovascularization 5 97.40 Very High Very High Very High
Diabetes Mellitus 33 95.40 Very High Very High Very High
Arthropathy 1 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It encodes a 1203 amino acid putative transmembrane protein that is highly homologous to the PTCH1 product.
Gene_expression (product) of PTCH1
1) Confidence 0.75 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 0.87 Pain Relevance 0
The expression level of Ptc, the Shh receptor, did not change during healing in an alkali-burned cornea.
Gene_expression (expression) of Ptc in cornea
2) Confidence 0.71 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.07 Pain Relevance 0
This report also shows that Shh activation is located upstream of VEGF in experimental retinal neovascularization under retinal hypoxic conditions because inhibition of the Shh pathway results in the reduction of VEGF level along with that of Patched-1 (Ptch1), a canonical Shh target.
Gene_expression (target) of Patched-1 associated with hypoxia and retinal neovascularization
3) Confidence 0.62 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.27 Pain Relevance 0
This report also shows that Shh activation is located upstream of VEGF in experimental retinal neovascularization under retinal hypoxic conditions because inhibition of the Shh pathway results in the reduction of VEGF level along with that of Patched-1 (Ptch1), a canonical Shh target.
Gene_expression (target) of Ptch1 associated with hypoxia and retinal neovascularization
4) Confidence 0.62 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.27 Pain Relevance 0
About 2-fold increase and 3-fold decrease in the expressions of PTCH1 and TRPC5, respectively, was observed upon AICD overexpression (Figure 1(a)).
Gene_expression (expressions) of PTCH1
5) Confidence 0.61 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2935165 Disease Relevance 0.06 Pain Relevance 0
Hence overexpression of PTCH1 by AICD could be a protective measure of cells against tumorigenesis.
Gene_expression (overexpression) of PTCH1
6) Confidence 0.61 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2935165 Disease Relevance 0.19 Pain Relevance 0
Shh did not affect the expression levels of angiogenic cytokines in cultured cell types. mRNA and protein expression levels of Shh and Ptc were under the detection limit in an uninjured cornea, but Shh but not Ptc was upregulated in a healing, alkali-burned, vascularized cornea.
Gene_expression (levels) of Ptc in cornea associated with cytokine
7) Confidence 0.55 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2684749 Disease Relevance 0.25 Pain Relevance 0.08
Shh did not affect the expression levels of angiogenic cytokines in cultured cell types. mRNA and protein expression levels of Shh and Ptc were under the detection limit in an uninjured cornea, but Shh but not Ptc was upregulated in a healing, alkali-burned, vascularized cornea.
Gene_expression (expression) of Ptc in cornea associated with cytokine
8) Confidence 0.55 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2684749 Disease Relevance 0.25 Pain Relevance 0.09
Because dysregulation of hedgehog signalling is a feature of several benign cartilaginous tumours, expression of the hedgehog target genes PTC1 and GLI1 was examined in this study in samples from human synovial chondromatosis.
Spec (examined) Gene_expression (expression) of PTC1 associated with cancer and synovial chondromatosis
9) Confidence 0.44 Published 2005 Journal J. Pathol. Section Abstract Doc Link 15834844 Disease Relevance 0.72 Pain Relevance 0.09
In addition to the increased insulin signaling in the liver with HS+MES treatment, we observed that HS+MES affected the levels of serum TNF-?
Gene_expression (affected) of MES in liver associated with shock and hyperinsulinism
10) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.32 Pain Relevance 0
Interestingly, HS+MES treatment enhanced the insulin-stimulated IR?
Gene_expression (treatment) of MES associated with shock
11) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.11 Pain Relevance 0
Animals and in vivo HS+MES treatment
Gene_expression (treatment) of MES associated with shock
12) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.46 Pain Relevance 0
Motor-debilitating effects (impairment of rotarod performance) occurred at doses about 10 times higher than those required for protection against MES.
Gene_expression (protection) of MES associated with convulsion
13) Confidence 0.04 Published 1996 Journal Neuropharmacology Section Abstract Doc Link 8887975 Disease Relevance 0.64 Pain Relevance 0.30

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