INT65926

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 28
Disease Relevance 12.91
Pain Relevance 4.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Anatomy Link Frequency
nerve 6
sensory nerves 4
lactotrophs 3
margin 2
epithelial cell 2
Egf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 171 100.00 Very High Very High Very High
Hyperalgesia 42 100.00 Very High Very High Very High
cytokine 176 99.88 Very High Very High Very High
Inflammation 225 98.26 Very High Very High Very High
aspirin 34 97.86 Very High Very High Very High
qutenza 19 97.68 Very High Very High Very High
Chronic pancreatitis 6 94.88 High High
agonist 144 94.64 High High
withdrawal 30 94.40 High High
metalloproteinase 58 91.52 High High
Disease Link Frequency Relevance Heat
Injury 87 100.00 Very High Very High Very High
Hyperalgesia 42 100.00 Very High Very High Very High
Pancreatic Cancer 6 100.00 Very High Very High Very High
Salivary Gland Disease 16 99.84 Very High Very High Very High
Ulcers 409 99.44 Very High Very High Very High
Pulmonary Hypertension 35 98.40 Very High Very High Very High
INFLAMMATION 248 98.26 Very High Very High Very High
Malignant Neoplastic Disease 3 98.24 Very High Very High Very High
Stress 329 97.70 Very High Very High Very High
Nociception 66 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that stimulation of EGF expression in salivary glands and serum may be one of the mechanisms by which capsaicin sensitive nerves contribute to the gastroprotective and ulcer healing actions in the stomach.
Positive_regulation (stimulation) of Gene_expression (expression) of EGF in nerves associated with qutenza, salivary gland disease and ulcers
1) Confidence 0.70 Published 2000 Journal Life Sci. Section Abstract Doc Link 11210723 Disease Relevance 0.93 Pain Relevance 0.59
This was accompanied by progressive increase in the GBF and an increase in expression of EGF mRNA in gastric mucosa, as detected by RT-PCR.
Positive_regulation (increase) of Gene_expression (expression) of EGF mRNA
2) Confidence 0.69 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9479624 Disease Relevance 0.77 Pain Relevance 0.43
These studies demonstrated unique properties of rebamipide and convincingly showed that it increases gastric mucus glycoprotein components, stimulates migration and proliferation of wounded epithelial cell monolayers, increases expression of epidermal growth factor and its receptor in normal and ulcerated gastric mucosa, and scavenges active oxygen radicals.
Positive_regulation (increases) of Gene_expression (expression) of epidermal growth factor in epithelial cell
3) Confidence 0.66 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753220 Disease Relevance 1.19 Pain Relevance 0.31
This adaptive cytoprotection appears to be mediated, in part, by endogenous PG, sensory nerves, and an arginine-NO-dependent pathway, and repeated applications of NH4OH induce gastric adaptation, probably mediated by enhanced expression of EGF and its receptors and by an increased cell proliferation.


Positive_regulation (enhanced) of Gene_expression (expression) of EGF in sensory nerves
4) Confidence 0.46 Published 1996 Journal Scand. J. Gastroenterol. Section Body Doc Link 8888429 Disease Relevance 0 Pain Relevance 0
Biological molecular processes for ulcer healing are comprised of inflammation, cell migration, mitosis, and remodeling, all of which are associated with the active synthesis and release of several peptide growth factors at the site of injury such as epidermal growth factor (EGF), transforming growth factor-alpha (TGF-?)
Positive_regulation (as) of Gene_expression (synthesis) of EGF associated with inflammation, injury and ulcers
5) Confidence 0.40 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386523 Disease Relevance 0.87 Pain Relevance 0.08
Immunohistochemical studies demonstrated that cells lining dilated gastric glands at the ulcer margin display an enormous increase in expression of EGF, EGFR, and TNF-a at the initial stage (1–7 days) after ulcer induction [7, 13, 15].
Positive_regulation (increase) of Gene_expression (expression) of EGF in margin associated with ulcers
6) Confidence 0.37 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386523 Disease Relevance 1.09 Pain Relevance 0
The expressions of EGF were considerably increased only in Group III.
Positive_regulation (increased) of Gene_expression (expressions) of EGF
7) Confidence 0.37 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386523 Disease Relevance 0.96 Pain Relevance 0
Biological molecular processes for ulcer healing are comprised of inflammation, cell migration, mitosis, and remodeling, all of which are associated with the active synthesis and release of several peptide growth factors at the site of injury such as epidermal growth factor (EGF), transforming growth factor-alpha (TGF-?)
Positive_regulation (as) of Gene_expression (synthesis) of epidermal growth factor associated with inflammation, injury and ulcers
8) Confidence 0.35 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386523 Disease Relevance 0.87 Pain Relevance 0.08
This adaptation may be of short term (adaptive cytoprotection) and follows the exposure to "mild" irritants that activate local mucosal biosynthesis of protective prostaglandins (PG) and nitric oxide (NO) and stimulate sensory nerves and mucosal cell migration and proliferation through enhanced expression of growth factors such as EGF, TGF alpha and trefoil peptides.
Positive_regulation (enhanced) of Gene_expression (expression) of EGF in sensory nerves
9) Confidence 0.31 Published 1997 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 9098824 Disease Relevance 0.41 Pain Relevance 0.20
With repeated insults of ulcerogens such as stress aspirin, Hp-derived gastrotoxins, especially ammonia, a long-term adaptation develops which is mediated mainly by overexpression of EGF and TGF alpha and their common receptor (EGFR) with subsequent increase of mucosal cell proliferation and enhanced healing of mucosal lesions.
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGF associated with stress, aspirin and ulcers
10) Confidence 0.31 Published 1997 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 9098824 Disease Relevance 0.27 Pain Relevance 0.17
This indicates that while physiologically effective EGF induced signalling is not necessarily dependent on Erk1/2 activation.
Positive_regulation (effective) of Gene_expression (effective) of EGF
11) Confidence 0.30 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.26 Pain Relevance 0.11
Phosphorylation of Erk1/2 differs strongly between NGF/GDNF and EGF treated neurons
Positive_regulation (between) of Gene_expression (/) of EGF in neurons
12) Confidence 0.30 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0 Pain Relevance 0
It is therefore plausible that various peptides from gonadotrophs act on the target PRL and GH cells via transactivation of the EGF-R expressed on lactotrophs and somatotrophs.
Positive_regulation (transactivation) of Gene_expression (expressed) of EGF-R in lactotrophs
13) Confidence 0.28 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.05
Fourteen patients (67%) with pancreatic cancer displayed tissue overexpression for EGF and 11 patients for EGF-R (52%).
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGF
14) Confidence 0.26 Published 1999 Journal Int. J. Pancreatol. Section Body Doc Link 10360220 Disease Relevance 0.12 Pain Relevance 0
EGF inhibits PGE2 induced mechanical hyperalgesia
Positive_regulation (induced) of Gene_expression (hyperalgesia) of EGF associated with hyperalgesia
15) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.71 Pain Relevance 0.78
1, as compared to those treated with LIF alone or with EGF or TGF?
Positive_regulation (treated) of Gene_expression (treated) of EGF
16) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0 Pain Relevance 0.06
Of great impetus in realising the importance of local humoral control has been the discovery of nerve growth factor (NGF) and epidermal growth factor (EGF) (28).
Positive_regulation (discovery) of Gene_expression (discovery) of EGF in nerve associated with nerve growth factor
17) Confidence 0.20 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 1.05 Pain Relevance 0.27
Nevertheless, as for several other EGF-like molecules, the TGF-?
Positive_regulation (several) of Gene_expression (several) of EGF
18) Confidence 0.20 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.06 Pain Relevance 0.09
In another more powerful approach, EGF-R signalling was blocked by overexpressing a dominant negative EGF-R, lacking the intracellular protein kinase domain, into GH and PRL cells.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of EGF-R
19) Confidence 0.20 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.27 Pain Relevance 0
Of great impetus in realising the importance of local humoral control has been the discovery of nerve growth factor (NGF) and epidermal growth factor (EGF) (28).
Positive_regulation (discovery) of Gene_expression (discovery) of epidermal growth factor in nerve associated with nerve growth factor
20) Confidence 0.20 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 1.05 Pain Relevance 0.27

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